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Understanding the biological mechanisms of l-dopa-induced motor complications is dependent on our ability to investigate these phenomena in animal models of Parkinson's disease. The most common motor complications consist in wearing-off fluctuations and abnormal involuntary movements appearing when plasma levels of l-dopa are high, commonly referred to as peak-dose l-dopa-induced dyskinesia. Parki
This paper addresses the effects of the deterioration on the value of damage detection information. The quantification of the value of damage detection information for deteriorated structures is based on Bayesian pre-posterior decision analysis, comprising structural system performance models, consequence, benefit and costs models and damage detection information models throughout the service life
BACKGROUND: There is a growing interest to increase dietary fiber (DF) consumption due to the health benefits associated with this nutrient. Pulses are considered a good source of non-digestible carbohydrates. The aim of this study was to investigate the possibility of substituting semolina with chickpea flour to increase the indigestible carbohydrate content without altering the texture of the pa
Lighting control systems have been traditionally employed to reduce energy use for lighting by, for example, maximizing daylight harvesting. When highly efficient light sources are installed and for tasks where maintaining target illuminance is particularly important, designers may decide to prioritize the latter together with energy use. In this context, the use of data-driven algorithms is emerg
The lower Cambrian Lagerstätte of Sirius Passet, Peary Land, North Greenland, is one of the oldest of the Phanerozoic exceptionally preserved biotas. The Lagerstätte evidences the escalation of numbers of new body plans and life modes that formed the basis for a modern, functionally tiered ecosystem. The fauna is dominated by predators, infaunal, benthic and pelagic, and the presence of abundant n
Closed-loop controlled drug dosing has the potential of revolutionizing clinical anesthesia. However, interpatient variability in drug sensitivity poses a central challenge to the synthesis of safe controllers. Identifying a full individual pharmacokinetic–pharmacodynamic (PKPD) model for this synthesis is clinically infeasible due to limited excitation of PKPD dynamics and presence of unmodeled d
Immune cell-derived cytotoxic pathways have been implicated in antitumor immune responses. The goal of this study is to characterize how these cytotoxic pathways influence ovarian cancer development. We have utilized the TgMISIIR-TAg transgenic mouse model which expresses the transforming SV40 TAg in the ovary, leading to spontaneous development of ovarian tumors that closely mimic human epithelia
To establish the contribution of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) for the incretin effect after oral glucose, studies were undertaken in female mice with genetic deletion of receptors for GIP and GLP-1 (double incretin receptor knockout [DIRKO] mice) and their wild-type (WT) counterparts. Insulin secretion was explored after oral glucose (doses
Let Us Remember Desmond - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Evaluation of Programme Work M
https://rwi.lu.se/news/let-us-remember-desmond/ - 2026-07-03
Inclusive Societies Archives - Page 7 of 10 - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Evaluation
https://rwi.lu.se/category/inclusive-societies/page/7/ - 2026-07-03
Over the past decade, the field of Inner Transformation for Sustainability has grown into a substantial and influential body of knowledge, providing much of the scientific foundation for the Inner Development Goals (IDGs). In this conversation, Professor Christine Wamsler and Tomas Björkman reflect on the current state of the field. They emphasize that any meaningful application of the IDG Guide r
Background: – Adverse muscle composition (AMC), defined by low muscle volume and increased muscle fat infiltration, has been associated with comorbidity and poor function in chronic kidney disease (CKD), and increased mortality in metabolic disorders and the general population. We investigated whether MRI-derived muscle composition is associated with all-cause mortality in a UK Biobank (UKB) imagi
The Anthropocene thesis, in its rejection of both the modernist separation between ‘humans’ and ‘nonhumans’ as well as in its treatment of ‘humans’ as a singular global geophysical force, presents fundamental challenges to constitutional theory and practice. First, in terms of conceptual and foundational transformations, the Anthropocene provokes the reconceptualisation of legal relations as never
BACKGROUND. Prostate-specific antigen (PSA/KLK3) and human kallikrein 2 (hK2/KLK2) belong to the human kallikrein gene family. These two highly homologous genes are specifically expressed in the prostate under androgen control. Expression of these is regulated by similar mechanisms but changes in their relative expression have been observed in prostate cancer. METHODS. We determined the relative l
IntroductionThe evidence for assessing whether a single stab injury to the trunk was inflicted by another person in an assault or self-inflicted has primarily been derived from autopsy studies. In this study, we investigate whether victim demographics, crime scene circumstances, and the injury characteristics of assault survivals are interchangeable with homicide characteristics, with a specific f
AIMS: Although age-related immune deterioration has been implicated as a mechanistic contributor to cardiovascular disease (CVD), evidence for an impairment of adaptive immune function in individuals with clinically verified presence of atherosclerosis is lacking.METHODS AND RESULTS: To test the association between atherosclerosis and immune function, we evaluated SARS-CoV-2 vaccine responsiveness
Screening mammography plays a key role in the early detection of breast cancer, however, estimates of sensitivities (48-88%) and specificities (82-98%) suggest that the diagnostic accuracy can be improved (1, 2, 3). Breast tomosynthesis (BT) is a 3D technique that is expected to improve breast cancer detection compared to screen-film and digital mammography DM). This work presents two clinical obs
Health is a universal right, nevertheless, not all people have the same opportunities to fully enjoy it without facing financial difficulties. Universal Health Coverage has the potential to break the health-poverty trap, supporting people with the opportunity of building a healthy structure, essential for a sustainable human and economic development. This paper explores how individual characterist
