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I understand patronage principally as a work of cultural and material support - the support shich was necessary to stage the performance of a piece of music in mayn different contexts. I focus on the fate of an opera, Richard Wagner's Parsifal, a work which was not performed at the Bayreuth festival between 1939 and 1944 because of its emphasis on reconciliation, non-violence and faith, but which
The morphological matrix is an important element of the engineering design methodology and is present in many textbooks. This method originally aimed at generating an exhaustive set of solutions for a given problem, by decomposing it into subproblems, finding solutions to each subproblem, and combining them. One issue associated with the morphological matrix has been the necessity to deal with the
Our group of researchers from a variety of backgrounds has been investigating the possibility of improving vision for patients with central scotoma. So far, these patients have only been offered enlarging devices and training. We hope that new knowledge about the peripheral vision optics of the eye will result in improvements in image quality and that this can be helpful for people with low vision
Identification of novel biomarkers for early diagnosis, prognosis, and treatment decision will be instrumental for improving disease outcome for patients suffering from complex diseases, such as cancer and autoimmune disorders. Within personalized medicine, the use of circulating biomarkers will allow clinicians to tailor medical treatment based on individual characteristics of each patient, using
Popular Abstract in Swedish Retrovirus är en typ av virus som finns hos både människor och djur. Detta virus sprider sig genom att en virus partikel tar sig in i en cell och sedan integrerar sin virala arvsmassa in i cellens arvmassa, DNA. Retrovirusets arvsmassa är från början RNA men skrivs sedan om till DNA för att kunna integreras. I molekylärbiologins barndom trodde man att det genetiska flödThe human genome contains genetic elements which are more or less similar to infectious retroviruses. These are called human endogenous retroviruses (HERVs) and are thought to be remnants of infections in the primate lineage. Most of them have been inserted 10 to 60 million years ago but have at different time points spread in the genome via intracellular retrotransposition and make up as much as
Leaked emails have revealed the Iran Experts Initiative (IEI), a covert network designed by the Islamic Republic of Iran’s diplomatic unit. Initiated in 2014, the IEI aimed to enhance Iran’s global sway by infiltrating think tanks. These leaks spotlight connections between Iranian experts and the Biden administration, extending the IEI’s influence even to European think tanks. This discovery under
The intestinal lumen contains an abundance of bacteria, viruses and fungi alongside ingested material that shape the chronically active intestinal immune system from early life to maintain the integrity of the gut epithelial barrier. In health, the response is intricately balanced to provide active protection against pathogen invasion whilst tolerating food and avoiding inflammation. B cells are c
The gut immune system protects against mucosal pathogens, maintains a mutualistic relationship with the microbiota, and establishes tolerance against food antigens. This requires a balance between immune effector responses and induction of tolerance. Disturbances of this strictly regulated balance can lead to infections or the development inflammatory diseases and allergies. Production of secretor
Reutilizing biomass ashes in agriculture can substitute inputs of P from finite primary sources. However, recycling of ashes is disputed due to their content of toxic substances such as heavy metals. This study evaluates the potential risk of replacing easily soluble inorganic P fertilizer with P in biomass ashes in a barley crop grown on soil with adequate P status. Two contrasting doses of three
The implementation of circular initiatives requires certain capabilities and knowledge that traditional business models often lack, requiring new perspectives and external collaborations. While it is understood that partnerships can aid in innovation and provide knowledge and capabilities to firms, the dynamics of collaboration for the transition towards circular business models (CBMs) need to be
Background: Joint damage in rheumatoid arthritis (RA) includes erosions and joint space narrowing (JSN). Predictors of these processes, and the underlying mechanisms, require further study1.Objectives: To investigate the relation between patient characteristics at RA diagnosis and progression of erosions and JSN, over 5 years. Methods: Consecutive early RA patients (symptom duration Results: 233 e
Research on IS solutions for environmental sustainability have evolved to a modest, but firm body of knowledge. Despite this progressive understanding about the potential of IS in enabling environmental sustainability, our academic practices seem widely unaffected by these insights. The way we do research or conduct teaching is rarely influenced by sustainability considerations. For example, befor
Many computer interfaces and assistive devices for people with motor disabilities limit the input dimensionality from user to system, in many cases leading to single switch interfaces where the user can only press one button. This can, either limit the level of direct access to the functionalities of the operating system, or slow down speed of interaction. In this paper we present TongueWise: a so
Although estrogen receptor-alpha (ERalpha) is a marker used to identify breast cancer patients most likely to benefit from endocrine therapy, approximately 50% of ERalpha-positive breast carcinomas are resistant to tamoxifen. Preclinical studies have shown that phosphorylation of ERalpha at serine-118 (ERalphaS118-P) is required for tamoxifen-mediated inhibition of ERalpha-induced gene expression.
For biomass fuelled CHP in sizes below 100 kW, Stirling engines are the only feasible alternative today. Using wood powder as fuel, the Stirling engine can be heated directly by the flame like when using a gaseous or liquid fuel burner. However, the combustion chamber will have to be much larger due to the slow burning of the fuel. To avoid sintering of ash the flame temperature in a biomass burne
In order to survive and thrive, organizations need to adapt, re-invent themselves and therefore innovate. However many intentional efforts to bring about innovation do not succeed. In order to be successful, innovation requires the support of individuals throughout the environment in which it is emerging. However, in many cases such support is not forthcoming for a variety of reasons. In this pape
