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Background: Early cartilage changes in knee osteoarthritis (OA) can be assessed by both intravenous (i.v.) and intra-articular (i.a.) delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). Purpose: To examine the relationship between i.a. dGEMRIC and delayed gadolinium-enhanced MRI of menisci (dGEMRIM), and to investigate if the approach can be used to assess the morphological degeneration of men
Background: Borderline ovarian tumors (BOTs) are a subgroup of ovarian malignancies with low malignant potential. Very limited earlier data are available on familial clustering of BOTs with other cancers. We aim to explore histology-specific familial associations among BOTs and associations between BOTs and any invasive cancers.Methods: On the basis of 16.1 million individuals in the Swedish Famil
In this article we define a new concept that has not previously been theorized: non-Muslim Islam. We argue that theories and methodologies within Islamic studies produce a hierarchy between Muslim and non-Muslim productions of Islam, prioritizing the first. However, this article highlights that Islam may be produced for other purposes than belief in a deity; Islam may for example be important in p
Tropical forests contribute a major sink for anthropogenic carbon emissions essential to slowing down the buildup of atmospheric CO2 and buffering climate change impacts. However, the response of tropical forests to more frequent weather extremes and long-recovery disturbances like fires remains uncertain. Analyses of field data and ecological theory raise concerns about the possibility of the Ama
Circulating mitochondrial DNA (mtDNA) is receiving increasing attention as a danger-associated molecular pattern in conditions such as autoimmunity, cancer, and trauma. We report here that human lymphocytes [B cells, T cells, natural killer (NK) cells], monocytes, and neutrophils derived from healthy blood donors, as well as B cells from chronic lymphocytic leukemia patients, rapidly eject mtDNA a
The Wee1 cell cycle checkpoint kinase prevents premature mitotic entry by inhibiting cyclin-dependent kinases. Chemical inhibitors of Wee1 are currently being tested clinically as targeted anticancer drugs. Wee1 inhibition is thought to be preferentially cytotoxic in p53-defective cancer cells. However, TP53 mutant cancers do not respond consistently to Wee1 inhibitor treatment, indicating the exi
Population ageing is putting pressure on pension systems and health care services, creating an imperative to extend working lives. At the same time, policy makers throughout Europe and North America emphasize home care. Thus, the number of people combining caregiving responsibilities with paid work is growing. We investigate the conflicts that arise from this by exploring the time costs of unpaid
Background: A substantial proportion of women with breast cancer (BC) experience a wide range of long-term persistent and troublesome side effects related to the disease and its treatment. The ReScreen randomized controlled trial is conducted aiming to evaluate the effect of early screening of distress followed by individualized rehabilitation after primary BC treatment.Purpose: To examine recruit
The spontaneous assembly of proteins into amyloid fibrils is a phenomenon central to many increasingly common and currently incurable human disorders, including Alzheimer's and Parkinson's diseases. Oligomeric species form transiently during this process and not only act as essential intermediates in the assembly of new filaments but also represent major pathogenic agents in these diseases. While
This study shows that the production of industrial and commercial waste should form part of normal organisational practices. When asked about waste prevention, representatives of food, textile, electronics and construction companies in Sweden have difficulties highlighting concrete waste-prevention objectives, measures and outcomes. Instead, they highlight economic, technical, and organisational b
AIMS: Tilt testing (TT) is recognized to be a valuable contribution to the diagnosis and the pathophysiology of vasovagal syncope (VVS). This study aimed to assess the influence of age on TT responses by examination of a large patient cohort.METHODS AND RESULTS: Retrospective data from three experienced European Syncope Units were merged to include 5236 patients investigated for suspected VVS by t
Code review occupies a significant amount of developers’ work time and is an established practice in modern software development. Despite misaligments between users’ goals and the code review tools and processes pointed out by recent research, the code review tooling has largely stayed the same since the early 90s. Improving these tools, even slightly, has the potential for a large impact spread o
Med denna guide vill vi ge forskningsbaserade råd om hur du kan minska dinklimatpåverkan genom att förändra dina levnadsvanor, och leva i linje medParisavtalets 1,5-gradersmål. Vi vill både visa svenskars genomsnittliga klimat-avtryck och den stora skillnaden mellan individers koldioxidavtryck. Det innebär attdet behövs olika vägval för de som vill förändra sina levnadsvanor. Guiden betonardessutoSyftet med denna guide är att ge forskningsbaserade råd om de mest effektiva sätten att minska sitt koldioxidavtryck för en genomsnittlig person i Sverige. Samtidigt visar den att individuella livsstilsförändringar måste kombineras med och stödjas av förändringar i det omgivande samhället. Dessutom ger guiden en allmän fingervisning om storleken på ditt koldioxidavtryck och om vilka delar av din v
This chapter examines the evolution of social class segregation in the city of Landskrona during the twentieth century. The city’s population was initially spatially mixed with regards to social class but became more segregated with industrialization. The study reveals that the segregation of higher white-collar workers increased drastically from 1940 to 1960, with a concentration of this group in
Food sharing is increasingly making its way in cities, offering new opportunities to tackle inequalities and shape more sustainable and resilient urban and peri-urban food systems. However, food sharing initiatives face multiple policy barriers that hinder its potential. Drawing on an international review of existing studies of Food Sharing Initiatives (FSI) governance, this first policy brief of
Informed by queer life practices, theories, and affinities, this documented artistic research project (doctoral thesis) draws from new materialist and post-humanist discourse in order to reconsider what role visual media play in the historical need to separate the human and the environmental. It asks, how do we challenge prevailing perceptions of film and photography as inexorably linked to ideas
