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Human papillomavirus type 16 (HPV-16) 5'-splice site SD3632 is used exclusively to produce late L1 mRNAs. We identified a 34-nt splicing inhibitory element located immediately upstream of HPV-16 late 5'-splice site SD3632. Two AUAGUA motifs located in these 34 nt inhibited SD3632. Two nucleotide substitutions in each of the HPV-16 specific AUAGUA motifs alleviated splicing inhibition and induced l
Chronic pulmonary disease is a recognized risk factor for invasive pneumococcal disease (IPD). However, previous studies have often not been large enough to allow detailed analyses of less prevalent pulmonary diseases, and findings regarding case fatality have been inconsistent. We examined the associations between an underlying pulmonary disease and IPD, and the impact of these diseases on the ca
The purpose of this thesis is to identify patents invented by researchers at Lund University, to describe the university inventors,and to understand the main factors that influence their patenting activities. The analysis focuses on inventors in relation to their environment. A number of factors influence scientists’ decisions to patent. Internal factors related to individuals such as solving the
Popular Abstract in Swedish Denna avhandling utgår från den betydande variationen i försäljning av antidepressiva läkemedel mellan olika geografiska områden. Allmänläkare förskriver cirka två tredjedelar av dessa läkemedel. Syftet med forskningsprojektet var dels att kartlägga allmänläkares uppfattningar om depression och faktorer som kan ha betydelse för deras sätt att behandla patienter med deprThis thesis emanates from considerations about the inter-regional variation of the sales of antidepressive drugs, and how general practitioners may contribute to that variation. The thesis comprises two data collections utilized for five separate studies. The first data set emerges from interviews with seventeen general practitioners and is used for papers I and II. The first paper reports on gene
Abstract not available
The aim of this article is to analyze verbally portrayed experiences of 27 survivors of the 1990’s war in northwestern Bosnia. The focus lies on evaluating interviewees’ description of wartime sexual violence and analyzing discursive patterns that contribute in constructing the phenomenon “sexualized war violence”. My analysis shows that the new social war order normalized the sexualized war viole
Lao PDR has been relatively successful in raising incomes and reducing poverty since the early 1990s. However, the gains in terms of poverty reduction are unevenly distributed across regions and population groups. This paper uses a detailed household survey data set to examine the determinants of income and poverty in Lao PDR. The results suggest that household size, dependency ratios, education,
The environmental footprint of IT products are significant and, in spite of manufacturing and product design improvements, growing consumption of electronics results in increasing absolute environmental impact. Computers have short technological lifespan and a lot of the in-build performance, although necessary, remains idling for most of the time. Today, most of computers used in non-residential
Helicobacter pylori is a gram-negative spiral-shaped bacterium that colonizes the human stomach and causes gastric inflammation, gastric and duodenal peptic ulcers, gastric cancer and MALT-lymphoma. A novel guinea pig model of H. pylori infection was developed. Infection was induced by oral inoculation and was confirmed by cultivation from the stomach mucosa. The infection led to severe gastric in
During my thirty years in the academic field I have always been interested in biographical studies. The focus has been on significant experiences in the individual’s life, so-called turning points, peak experiences or other decisive and unforgettable moments. Was there a crisis of some kind? And, if this is the case,how did the person in question cope with this low point in his or her life? I lear
Hepatitis B virus (HBV) infection is one of most common viral infections worldwide. While chronic HBV infection has been shown consistently to be associated with hepatocellular carcinoma, data on associations with cancers at other sites are limited. In this study a total of 10,197 patients were diagnosed with chronic HBV infection in Sweden, and they were retrieved from the nationwide Swedish Hosp
Non-steroid anti-inflammatory drugs (NSAIDs) are frequently occurring in sludge and waters from sewage treatment plants (STPs). Sludge obtained from sewage treatment is often applied as a fertilizer in agriculture and not many studies about the uptake of pharmaceuticals into crops can be found. In this paper, we present a greenhouse experiment to study the presence of four NSAIDs (naproxen, ketopr
Nutrient fluxes to coastal areas have risen in recent decades, leading to widespread hypoxia and other ecological damage, particularly from nitrogen (N). Several factors make N more limiting in estuaries and coastal waters than in lakes: desorption (release) of phosphorus (P) bound to clay as salinity increases, lack of planktonic N fixation in most coastal ecosystems, and flux of relatively P-ric
This paper aims to contribute to the knowledge on innovation processes in low- and medium-low-tech industries. Today, industries characterised as high-tech are perceived to be central to economic development, as the research intensity shields them from competition from low-wage countries. This is less the case for low-tech industries, but their economic importance continues to be large, however. I
Diabetes is a much more heterogeneous disease than the present subdivision into types 1 and 2 assumes; type 1 and type 2 diabetes probably represent extremes on a range of diabetic disorders. Both type 1 and type 2 diabetes seem to result from a collision between genes and environment. Although genetic predisposition establishes susceptibility, rapid changes in the environment (ie, lifestyle facto
