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Combinations of genetic and environmental factors contribute to the pathogenesis of type 2 diabetes (T2D); however, our knowledge of the molecular mechanisms by which these factors trigger diabetes is still limited. While genome-wide association studies have identified and characterized more than 60 genomic loci associated with T2D, recent methylome charts and reference regulatory maps obtained fr

This paper is focused on implementation challenges related to the integration of sustainable mobility in strategic local/regional land use and transport planning. The work was based on a case study of Stockholm, Sweden, focusing on four current plans and strategies of key importance for sustainable mobility. We identify and discuss implementation challenges related to sustainable mobility using a

Background: Familial prostate cancer risk estimates are inflated by clinically insignificant low-risk cancer, diagnosed after prostate-specific antigen testing. We provide age-specific probabilities of non-low- and high-risk prostate cancer. Methods: Fifty-one thousand, eight hundred ninety-seven brothers of 32 807 men with prostate cancer were identified in Prostate Cancer data Base Sweden (PCBaS

At REX-ISOLDE at ISOLDE/CERN radioactive ions are post accelerated with a 10 meters linac for experiments in nuclear-, astro- and solid state physics. For the efficient acceleration to energies between 0.8 and 2.3 MeV/u the principles of charge breeding of radioactive ions by an electron beam source was introduced at REX. The linac in its current stage consists of a 4-rod RFQ, a 20-gap IH drift tu

Lao PDR has shown a strong record of economic growth and poverty alleviation since the early 1990s. Yet, the pace of economic development has varied significantly between different parts of the country - the rate of growth was initially faster in more developed areas, but after the mid-1990s growth has been stronger in poorer rural areas. Here it is shown that this pattern of regional development

I det här kapitlet behandlas begreppet välfärd kopplat till tjänster och som det uppfattas av mottagarna av tjänsterna, ”kunderna”, men även hur välfärdens värde traditionellt aggregeras på samhällsnivå och de brister som finns i de mått som används. Syftet är att diskutera om de mått och uttryck för välfärd vi använder idag tillräckligt väl speglar det vi menar med ”välfärd”. Kan de mått som anvä

The current form-giving activity in industrial design is characterized by explorations that depend on the individual capability to mentally manipulate a solution space from which to select and express the intended result. Designers often rely on artistic experimentation, aesthetic inspiration, or product specifications. These approaches often lead to satisfactory results, but they could be augment

The management of construction tolerances is a necessary and routine part of the construction activity and is normally brought to our attention only when failures are reported. In a study of tolerance management, the authors found widespread evidence of the same failures and the reasons for them. There seems to be no shortage of experience of the effects of failures in tolerances or of knowledge a

Popular Abstract in Swedish Avhandlingen omfattar två delstudier. Huvudfokus är en fältstudie, där syftet är att förstå obotlig sjukdom och döden som konkreta erfarenheter på aktörsnivå. Med hjälp av observationer och intervjuer följs nio döende, anhöriga och sjuksköterskor under en tid i familjens hem. Den andra delstudien är en diskursanalys av danska socialpolitiska rapporter om det palliativa The dissertation deals with two part-studies. The main focus is a field study the purpose of which is to understand incurable disease and death as hands-on experiences at the player's level. With the aid of observations and interviews, nine dying people, relatives and community nurses are followed in the families? homes over time. The second part-study is a discourse analysis of Danish health-poli

New and innovative production equipment can be developed by introducing lightweight materials in modern day automotive industry production lines. The properties of these new materials are expected to result in improved ergonomics, energy savings, increased flexibility and more robust equipment, which in the end will result in enhanced productivity. Carbon composite materials are one such alternati

In recent years, public, scientific and governmental interest in ecotourism in Scandinavia has grown substantially. This book is the first to comprehensively describe, analyse and evaluate aspects of Scandinavian ecotourism. It will appeal to researchers and students of tourism in general and ecotourism in particular.

Popular Abstract in Swedish Det finns idag en uttalad strävan från samhällets sida att höja den arki-tektoniska kvaliteten i den byggda miljön. Den svenska bygg-lagstiftning-en är sedan ett par år tillbaka ändrad så att hänsyn måste tas också till estetiska kvaliteter när ändringar i den fysiska miljön ska genomföras. I den regerings-proposition som föregick lagändringen pekas arkitektur och desigThis dissertation deals with aesthetic rules in an urban context. The dissertation develops a theoretical framework for understanding the role of aesthetic rules, especially urban design codes, in the process of improving the architectural quality of the built environment. In the context of this framework three case studies of urban design codes are presented. The over-arching aim is hermeneutical

In this contribution, we reflect on the particular function of international criminal law to prevent refugee crises of the type that provided a major trigger for the debate on military and legal interventionism in the 1990s. Based on the dichotomy of formal and substantive justice, we analyze the achievements of International Criminal Tribunals and look into the Gotovina judgment in particular. We

Long term follow up of 16 homosexual men and 78 intravenous drug abusers who were chronic carriers of hepatitis B surface antigen (HBsAg) showed fundamental differences between the two groups. Viral replication, expressed by the presence of hepatitis B e antigen, lasted for four years or more in 10 out of 14 (71%) of the homosexual men whereas it was not present in 43 out of 73 (59%) of the drug a

Popular AbstractSveriges första stora kärnkraftsreaktor togs i bruk 1972. Samma år kom kärnkraften att för första gången på allvar ifrågasättas i den svenska riksdagen. Under loppet av ett par år förvandlades kärnkraftsfrågan till den nutida svenska politikens kanske mest kontroversiella och omdebatterade fråga. I denna avhandling analyseras den riksdagspolitiska debatten om kärnkraften mellan åreThis study applies a qualitative discourse theoretical method to analyse the central argumentation in the parliamentary debate on nuclear power in Sweden during 1972­1980, reconstructed from official documents such as governmental and parliamentary bills, committee reports, parliamentary debate protocols, and official commission reports. Particular concern is directed to the process in which vari