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While immunomodulatory monoclonal antibodies (mAbs) have therapeutic efficacy against many tumors, few patients are cured. Attempting to improve their therapeutic efficacy we have applied the TC1 mouse lung carcinoma model and injected established subcutaneous tumors intratumorally with 3 weekly doses of various combinations of mAbs. Combinations of mAbs to CTLA4/PD1/CD137 (the 3 mAb combination)
The gun test stand from MAX-Lab has been upgraded and moved to a new facility at the MAX IV Laboratory. The new test stand will reuse parts of the equipment from the old test stand but a number of improvements to the setup are be made. In this paper we report on the design of the new gun test stand, research plans in the near future as well as planned and possible future research topics..
The rock mass viscous behaviour during tunnel construction is discussed. Initially, a brief introduction to the squeezing phenomenon and its association with the related one of creep is provided. Then, existing simplified models of rheological rock mass behaviour are presented and analysed. The range of the viscoelastic rock parameters identified in the literature for weak rocks is also given and
Background: Sodium-glucose co-transporter 2 (SGLT2) inhibitors have been shown to reduce rates of heart failure hospitalisations and cardiovascular death in patients with type 2 diabetes and prior cardiovascular disease. We hypothesised that SGLT2 inhibitors could provide cardiovascular benefits in the post-myocardial infarction setting. We aimed to investigate cardiovascular outcomes of SGLT2 inh
In this paper I will introduce a conceptualisation of that kind of thinking which per definition precedes the coming up with a novel idea. By the use of basic etymology, I have named this cognitive phenomena preflexivity. As thereby indicated, I propose that preflexivity, on an analytical level, comes before reflexivity. What I aim to highlight through the lens of preflexivity is the generative po
BACKGROUND: An unhealthy diet is a major contributor to several noncommunicable diseases, including cardiovascular diseases (CVD), the leading cause of death worldwide. Additionally, our food system has significant impacts on the environment. The EAT-Lancet Commission has recommended a healthy diet that preserves global environmental resources.OBJECTIVE: This prospective study evaluated the associ
Risk stratification has gained an increasing role in predicting outcomes and guiding the treatment of patients with pulmonary arterial hypertension (PAH). The most predictive prognostic factors are three noninvasive parameters (World Health Organization functional class, 6-min walk distance and natriuretic peptides) that are included in all currently validated risk stratification tools. However, s
Performance of a proton exchange membrane (PEM) fuel cell is very sensitive to its electric resistance appearing in its functional components. In this paper, the electric resistance as well as related parameters of a cell is evaluated by a recently developed numerical method in the through-plane direction of the electrodes. The results show that the channel/rib structure leads to non-homogeneous e
When the assembly force is applied, the gas diffusion layer (GDL) deformation is observed and the geometry and transport parameters are also changed. Accordingly, the transport processes and cell performance are affected due to the deformation effect. In the present study, a three-dimensional, non-isothermal, two-phase flow model was developed and applied to investigate the effect of GDL deformati
While it is evident that photovoltaic installations are becoming more and more widespread globally, demand for them in the Russian market remains low. Considering recent changes in the legal framework, which are beneficial for households with renewable energy, it is crucial to evaluate photovoltaic installation's economic feasibility for the Russian context, which is evaluated in this article. Fir
We present smoothed particle hydrodynamic models of the interactions in the compact galaxy group, Stephan’s Quintet. This work is extension of the earlier collisionless N-body simulations of Renaud et al. in which the large-scale stellar morphology of the group was modelled with a series of galaxy–galaxy interactions in the simulations. Including thermohydrodynamic effects in this work, we further
BACKGROUND: A history of hypertensive disorders of pregnancy is associated with at least twice the risk of incident ischemic heart disease. Whether the long-term outcome following treatment with coronary artery stenting is associated to the history of hypertensive disorders of pregnancy is unknown. METHODS AND RESULTS: We included 8364 women (age ≤65 years) undergoing first coronary artery stentin
The association between obesity and psychological stress is ambiguous. The aim is to investigate the association between metabolic syndrome (MetS) and body mass index (BMI), respectively, with occupational stress among Japanese office workers. The study is a secondary analysis of the intervention group from a randomized controlled trial. There are 167 participants included in the analysis. Occupat
In this paper we study the interaction between starch which has been hydrophobically modified, with octenyl succinic anhydride (OSA), and alpha-beta-livetin, which is the water soluble fraction of egg yolk. The modification of the starch renders it surface active and also incorporates a carboxyl group to the starch, which can be negatively charged. The interaction was studied both in solution and
IDO1 can be induced by interferon gamma (IFN-γ) in multiple cell types. We have earlier described that the DNA methyltransferase inhibitor zebularine also induces IDO1 in several rat cell clones. We now describe a synergistic induction of IDO1 expression by IFN-γ and zebularine. To elucidate the mechanism of the IDO1 induction we have studied the methylation status in the promoter region of the ID
A quarter of DA white dwarfs are metal polluted, yet elements heavier than helium sink down through the stellar atmosphere on time-scales of days. Hence, these white dwarfs must be the currently accreting material containing heavy elements. Here we consider whether the scattering of comets or asteroids from an outer planetary system, following stellar mass-loss on the asymptotic giant branch, can
Background: Sunitinib malate is approved multinationally for the treatment of metastatic renal cell carcinoma (mRCC) and advanced imatinib-refractory gastrointestinal stromal tumour (GIST). Greater exposure to sunitinib is associated with improved efficacy. Therefore, minimising the impact of adverse events (AEs) on patient quality of life is important to enable patients to achieve optimal exposur
Digital gameplay is now firmly embedded in everyday practices in many Scandinavian homes. This paper deals with the constitution of such practices in families by taking a closer look at the material objects essential to play and their role in the “design of everyday life” (Shove et al 2007). It uses ethnographic method and anthropological practice theory to attend to the domestic spaces of leisure
Human monocytes are a heterogeneous cell population classified into three different subsets: Classical CD14++CD16-, intermediate CD14++CD16+, and non-classical CD14+CD16++ monocytes. These subsets are distinguished by their differential expression of CD14 and CD16, and unique gene expression profile. So far, the variation in inter-cellular gene expression within the monocyte subsets is largely unk
