Filetype
AIMS/HYPOTHESIS: Voltage-gated calcium channels of the L-type have been shown to be essential for rodent pancreatic beta cell function, but data about their presence and regulation in humans are incomplete. We therefore sought to elucidate which L-type channel isoform is functionally important and its association with inherited diabetes-related phenotypes. METHODS: Beta cells of human islets from
Inflammatory challenges of the airway mucosa cause luminal entry of bulk plasma. Extravasation of plasma is well described but the routes for epithelial passage of plasma are largely unknown. Using colloidal gold (5 nm) as tracer we have now examined the fate of extravasated plasma in the airways. The tracer was given intravenously to anaesthetized, ovalbumin-sensitized guinea-pigs 2min prior to a
Mutated Nucleophosmin 1 (NPM1) is the most common genetic alteration in acute myeloid leukemia (AML), found in approximately 30% of cases. Although mutations in this gene are considered favorable according to current risk stratification guidelines, a large fraction of patients will suffer from relapse, demonstrating the urgent need for new treatment options. Therefore, we aimed to identify cell su
In order to investigate the molecular basis for the ability of the human B1 and B2 bradykinin (BK) receptor subtypes to discriminate between subtype- selective ligands, we constructed chimeric proteins in which the sixth transmembrane domains (TM-VI) of these receptors were exchanged. The pharmacological profiles of the constructs were analyzed by radioligand binding in particulate preparations of
In mudflats, interactions and transfers of nutrients and secondary metabolites may drive ecosystems and biodiversity. Foraminifera have complex trophic strategies as they often rely on bacteria and eukaryotes or on potential symbionts for carbon and nitrogen resources. The capacity of these protists to use a wide range of adaptive mechanisms requires clarifying the relationships between them and t
AIMS/HYPOTHESIS: The molecular mechanisms of insulin release are only partially known. Among putative factors for coupling glucose metabolism to insulin secretion, anaplerosis has lately received strong support. The anaplerotic enzyme pyruvate carboxylase is highly expressed in beta cells, and anaplerosis influences insulin secretion in beta cells. By inhibiting pyruvate carboxylase in rat islets,
WCMM Fellow | Cell Reprogramming in Hematopoiesis and Immunity Our research The focus of our laboratory is to understand the molecular determinants underlying cell reprogramming and hematopoietic specification. In humans, the multiple differentiated cell states are normally stable and inherited through cell division. Under certain conditions, cell fate can, however, be modified or reversed. Cell r
https://www.wcmm.lu.se/filipe-pereira - 2026-07-17
Microsoft Word - Post-doc Bioinformatics.doc Post doc position at Lund Stem Cell Center Bioinformatician Postdoctoral Fellowship in the Stem Cells, Aging and Neurodegeneration group Lund Stem Cell Center is an internationally ranked research center in the strategic areas of Stem Cell Biology and Regenerative Medicine within Lund University, Scandinavia’s largest institution for education and resea
https://www.stemcellcenter.lu.se/sites/stemcellcenter.lu.se/files/ahlenius_group_post-doc_bioinformatics_position.pdf - 2026-07-18
Delegated decisions, enclosure 2 Travel Grants Applicant Amount (SEK) Activity Approved by Group affiliation Date of approval Ellen Singleton 18 000 AP/PD 2024 International Conference on Alzheimer’s and Parkinson’s Diseases, 5-9 March 2024, Lisbon, Portugal Angela Cenci Nilsson Oskar Hansson 2024-01-02 Anika Wüstefeld 12 858 European Alzheimer Academy Workshop, Bertinoro, Italy, 17- 22 March 2024
https://www.multipark.lu.se/sites/multipark.lu.se/files/2024-12/2024-11-21%20signed.pdf - 2026-07-18
19 March 2026 13:30 to 17:00 | Conference This half-day interdisciplinary PhD conference brings together doctoral students and supervisors from different faculties at Lund University who engage with computational approaches in their research. The aim is to create a shared space for learning and discussion, and to exchange computational thinking as a core research practice across disciplinary bound
https://www.staff.lu.se/calendar/interdisciplinary-phd-conference-computational-thinking - 2026-07-18
Precision-cut lung slices (PCLS) have gained increasing interest as a model to study lung biology and disease, as well as for screening novel therapeutics. In particular, PCLS derived from human tissue can better recapitulate some aspects of lung biology and disease as compared to PCLS derived from animals (e.g. clinical heterogeneity), but access to human tissue is limited. A number of different
The human brain is a masterpiece of intricate design and impeccable functionality. It serves as the ultimate command center for our thoughts, sensations, and actions, which define our very existence. This organ operates flawlessly, with billions of neurons working in perfect harmony to process information, create memories, and regulate our emotions. The brain's neural network is composed of trilli
Immune checkpoint inhibitors have drastically improved the prognosis for several cancer patients, but still the exact underlying mechanism behind cancer immune escape and the role of individual immune cell populations remains poorly understood. Thus, further insights into the level of immune cell infiltration in cancers, their functional role, level of activation and maturity are warranted in orde
Of all live births with congenital anomalies, approximately one-third exhibit deformities ofthe head and face. Most craniofacial disorders are associated with defects in a migratory stem and progenitor cell population, which is designated the neural crest (NC). Musculocontractural Ehlers-Danlos syndrome (MCEDS) is a heritable connective tissue disorder with distinct craniofacial features; this syn
Microsoft Word - NGS_inftrastructure report 2021.docx Multipark infrastructure report form 2021 [Infrastructure name]: NextGen Sequencing (NGS) [Name of infrastructure manager/contact person]: Johan Jakobsson 1. Short description of the infrastructure. The MultiPark next generation sequencing (NGS) facility is located at the BMC in Lund. The core offers state-of-the art next generation sequencing
