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Recently, we constructed a focused antibody library tailored to interact with haptens. High functionality of this library was demonstrated, as specific binders could be retrieved to a range of different haptens. In the current study we have developed a mutagenesis and selection strategy in order to further fine-tune the hapten binding properties of these antibody fragments. Testosterone was chosen
Epilepsy is one of the most common neurological disorders that is characterized by recurrent and unpredictable seizures. Wearable systems can be used to detect the onset of a seizure and notify family members and emergency units for rescue. The majority of state-of-the-art studies in the epilepsy domain currently explore modern machine learning techniques, e.g., deep neural networks, to accurately
Recently, metal halide perovskites have been hailed by many as the “wonder” semiconductor for photovoltaics, because of their outstanding optoelectronic properties and facile solution processability. Perovskite-based solar cells have reached a power conversion efficiency record above 25% in just more than a decade of research. Halide perovskite semiconductors constitute a wide family of materials
We measure the surface of CH3NH3PbI3 single crystals by making use of two-photon photoemission spectroscopy. Our method monitors the electronic distribution of photoexcited electrons, explicitly discriminating the initial thermalization from slower dynamical processes. The reported results disclose the fast-dissipation channels of hot carriers (0.25 ps), set an upper bound to the surface-induced r
Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tested up to 235,116 single nucleotide variants (SNVs) on the exome-array for association with smoking initiation, cigarettes per day, pack-years, and sm
We propose drl-RPN, a deep reinforcement learning-based visual recognition model consisting of a sequential region proposal network (RPN) and an object detector. In contrast to typical RPNs, where candidate object regions (RoIs) are selected greedily via class-agnostic NMS, drl-RPN optimizes an objective closer to the final detection task. This is achieved by replacing the greedy RoI selection pro
The tetanus neurotoxin (TeNT) is a highly potent toxin produced by Clostridium tetani that inhibits neurotransmission of inhibitory interneurons, causing spastic paralysis in the tetanus disease. TeNT differs from the other clostridial neurotoxins by its unique ability to target the central nervous system by retrograde axonal transport. The crystal structure of the tetanus toxin reveals a "closed"
Hjärntumörer utgör omkring 2 procent av alla cancerdiagnoser och den vanligaste elakartade hjärntumörtypen är glioblastom (GBM). Patienter med GBM behandlas i dag med kirurgi, cellgifter och strålbehandling, men sjukdomen går sällan att bota och det krävs nya och mer effektiva behandlingsstrategier.I min doktorsavhandling har jag använt tre olika musmodeller, kallade GL261, KR158 och SB28, för attAdvances in surgery, chemo- and radiotherapy have only modestly improved survival rates of malignant brain tumor patients during the last decades. Emerging evidence suggests that an efficient treatment of malignant brain tumors will likely require the management of multiple aspects of tumor pathobiology in order to manipulate features as tumor heterogeneity and tumor immunosuppression. Immunothera
We present an assay, based on optical DNA mapping in nanochannels that is capable of characterizing the plasmid content of bacterial isolates resistant to antibiotics in a fast an detailed way. In a single experiment we determine the number of different plasmids in each sample, their size, as well as a barcode that can be used for plasmid identification and tracing. In addition we demonstrate that
Sixty-nine consecutive patients ( median age 54 years) were prospectively enrolled in a single-institution protocol for allogeneic transplantation with adjusted non-myeloablative fludarabine - melfalan-based conditioning including cyclosporin A and MMF, and one of three modes of serotherapy. Thirty-one donors (45%) were unrelated. The first cohort of 29 had ATG (Thymoglobulin 2 mg/kg x 3 days), th
Introduction Sweden, as many other high-income countries, has adopted guidelines to offer induction of labour at 41+0 gestational weeks to decrease the risk for perinatal death. As more than 20% of the pregnant population reach this gestational age, and along with other contributing factors, induction rates have increased up to 30% in many countries. Both women and care providers have raised the q
We present results of the commissioning of a new injector for the Brazilian Synchrotron Light Source. The new injector consists of the existing 125-MeV LINAC and a new 500-MeV booster synchrotron. At present, about 40 mA can be injected into the booster and about 15 mA can be ramped up to 500 MeV at a repetition rate of 0.17 Hz. The new injector has allowed the accumulation of up to 540 mA in the
Using the excess energy of charge carriers excited above the band edge (hot carriers) could pave the way for optoelectronic devices, such as photovoltaics exceeding the Shockley-Queisser limit or ultrafast photodetectors. Semiconducting nanowires show promise as a platform for hot-carrier extraction. Proof of principle photovoltaic devices have already been realized based on InAs nanowires, using
Characteristic modes of arbitrary 2-D periodic systems are analyzed using scattering parameter data. This approach bypasses the need for periodic integral equations and allows for characteristic modes to be computed from generic simulation or measurement data. Example calculations demonstrate the efficacy of the method through comparison against a periodic method of moments (MoM) formulation for a
Objectives Accumulating evidence suggested that the laminin Î 32 (LAMC2) expression level was upregulated in various cancers. However, the potential prognostic value of LAMC2 in cancers remains unclear. We conducted a meta-analysis to clarify the association of LAMC2 expression with prognosis. Design We searched Embase, Web of Science and PubMed (up to 25 November 2021) to collect all eligible stu
Great attention has been paid to developing low bandgap non-fullerene acceptors (NFAs) for matching wide bandgap donor polymers to increase the photocurrent and therefore the power conversion efficiencies (PCEs) of NFA organic solar cells, while pyrene-core based acceptor-donor-acceptor (A-D-A) NFAs have been mainly reported via the 2,9-position connection due to their bisthieno[3′,2′-b']thienyl[a
Malawi Polyomavirus Is a Prevalent Human Virus That Interacts with Known Tumor Suppressors Christian Berrios,a,b Joonil Jung,c Blake Primi,d,e Michael Wang,f Chandrasekhar Pedamallu,a,c Fujiko Duke,a,c Christina Marcelus,a Jingwei Cheng,a,g Robert L. Garcea,d,e Matthew Meyerson,a,c,h James A. DeCaprio,a,b,g the TEDDY Study Group Department of Medical Oncology, Dana-Farber Cancer Institute, Boston,
https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/38%2006032016_679_38_Berrios_JVirology_2014.pdf - 2026-07-23
Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease Nature Structural & Molecular Biology nature structural & molecular biology https://doi.org/10.1038/s41594-024-01320-8Article Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease Vivien Horváth 1, Raquel
