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Human pluripotent stem cell-derived in vitro models, combined with advances in high-content live-cell calcium imaging, provide a powerful platform for disease modeling and drug screening. However, most calcium imaging analysis tools have been developed for in vivo applications with suboptimal features for processing data from cultured neurons. Here, we present LUMIN (Live-cell User Module for Imag
Associative learning in the cerebellum underlies motor memories and probably also cognitive associations. Pavlovian eyeblink conditioning, a widely used experimental model of such learning, depends on the cerebellum, but the memory locus within the cerebellum as well as the underlying mechanisms have remained controversial. To date, crucial information on how cerebellar Purkinje cells change their
The study of brain development in humans is limited by the lack of tissue samples and suitable in vitro models. Here, we model early human neural tube development using human embryonic stem cells cultured in a microfluidic device. The approach, named microfluidic-controlled stem cell regionalization (MiSTR), exposes pluripotent stem cells to signaling gradients that mimic developmental patterning.
CD4 tissue-resident memory T cells (TRM) are crucial adaptive immune components involved in preventing influenza A virus (IAV) infection. Despite their importance, their physiological role in the upper respiratory tract, the first site of contact with IAV, remains unclear. Here, we find that, after IAV infection, antigen-specific CD4 TRM persist in the nasal tissue (NT) compartment after infection
Congenital vascular malformations, affecting 0.5% of the population, often occur in the head and neck, complicating treatment due to the critical functions in these regions. Our previous research identified distinct developmental origins for blood and lymphatic vessels in these areas, tracing them to the cardiopharyngeal mesoderm (CPM), which contributes to the development of the head, neck, and c
T helper 17 (T H17) cells located at the Peyer's patch (PP) inductive site and at the lamina propria effector site of the intestinal immune system are responsive to both pathogenic and commensal bacteria. Their plasticity to convert into follicular helper T (T FH) cells has been proposed to be central to gut immunoglobulin A (IgA) responses. Here, we used an IL-17A fate reporter mouse and an MHC
Popular Abstract in Swedish Den här avhandlingen handlar om ett protein, en receptor, kallad GPR30. GPR30 tillhör proteinfamiljen G protein-kopplade receptorer vilka är nödvändiga för att celler ska kunna kommunicera med varandra och med sin omgivning. Förenklat sätt kan de ses sitta på ytan av en cell där de väntar på att någonting ska binda till dem, vilket aktiverar receptorerna och får dem att
Effective microbial bioprocessing relies on maintaining ideal cultivation conditions, highlighting the necessity for tools that monitor and regulate cellular performance and robustness. This study evaluates a fed-batch cultivation control system based on at-line flow cytometry monitoring of intact yeast cells having a fluorescent transcription factor-based redox biosensor. Specifically, the biosen
The Human Rights of Women - Liu Xiaonan - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Evaluation of
https://rwi.lu.se/download/the-human-rights-of-women-liu-xiaonan/ - 2026-07-12
Liu Xiaonan Archives - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Evaluation of Programme Work Meth
https://rwi.lu.se/author-in-rwi-publications/liu-xiaonan/liu-xiaonan-liu-xiaonan/ - 2026-07-12
The development of the human embryonic brain is a complex process involving several biological cues which interact to generate speci_c neural cells and anatomical features. There are still many questions to be addressed regarding biological key mechanisms which in case of malfunction might disturb the development of the brain. Animal models such as rats and mice have been used to get a better unde
This chapter discusses the purification of islets and cells from islets. The pancreatic islets that are composed of several hormone-producing cells can be isolated by collagenase digestion of the pancreas. The yield of islets relative to the total number is usually small. Sufficient number of islets for a variety of functional and biochemical studies can be obtained by gradient centrifugations or
fcell-2022-1023279 1..17 Silk scaffolding drives self-assembly of functional and mature human brain organoids Edoardo Sozzi1, Janko Kajtez1, Andreas Bruzelius2, Milan Finn Wesseler3, Fredrik Nilsson1, Marcella Birtele1, Niels B. Larsen3, Daniella Rylander Ottosson2, Petter Storm1, Malin Parmar1 and Alessandro Fiorenzano1* 1Department of Experimental Medical Science, Developmental and Regenerative
4–9 November (workshop 3 incl. exhibition), 7–11 October (workshop 2), 9–13 September 2024 (workshop 1) Spatial audio is currently experiencing a renaissance period through the rise of various extended reality (XR) applications and adoption by mainstream media such as Apple Music, Netflix and major cinema releases. This has occurred alongside rapid spatial audio development within arts, music and
https://www.iac.lu.se/spatial-audio-workshop - 2026-07-15
