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Epigenetic silencing defends against LINE-1 (L1) retrotransposition in mammalian cells. However, the mechanisms that repress young L1 families and how L1 escapes to cause somatic genome mosaicism in the brain remain unclear. Here we report that a conserved Yin Yang 1 (YY1) transcription factor binding site mediates L1 promoter DNA methylation in pluripotent and differentiated cells. By analyzing 2

https://www.ctg.lu.se/services/single-cell/flex-gene-expression - 2026-07-15

Unravelling fundamental cellular mechanisms for use in biomedical applications. We open new possibilities for fundamental studies in life science by designing nanostructures of relevance for cells and biomolecules. The structures can also be used to create new tools for devices and diagnostics. Our research results are translated into applications within biophysics, brain science, and personalized

https://www.nano.lu.se/research/life-science-nano - 2026-07-15

Brevmall Facul ty o f Medic ine Department o f Labora tory Medic ine, Lund Announcement: Post doc scholarship in Spatial Chemical Mapping of Normal and Transformed Tissue Scholarship The aim of the scholarship is to offer an opportunity for a postdoc candidate with any background within the medical sciences or natural sciences to learn from a uniquely transdisciplinary research team. The team work

https://www.intramed.lu.se/sites/intramed.lu.se/files/2023-03/Post%20doc%20scholarship%20in%20Spatial%20Chemical%20Mapping%20of%20Normal%20and%20Transformed%20Tissue%20V%202023-474_v2.pdf - 2026-07-16

Neuroblastoma is a childhood developmental cancer; however, its embryonic origins remain poorly understood. Moreover, in-depth studies of early tumor-driving events are limited because of the lack of appropriate models. Herein, we analyzed RNA sequencing data obtained from human neuroblastoma samples and found that loss of expression of trunk neural crest–enriched gene MOXD1 associates with advanc

Regulation of development and entry into sporulation is critical for fungi to ensure survival of unfavorable environmental conditions. Here we present an analysis of gene sets regulating sporulation in the homothallic ascomycete Ashbya gossypii. Deletion of components of the conserved pheromone/starvation MAP kinase cascades, e.g., STE11 and STE7, results in increased sporulation. In kar3 mutants Regulation of development and entry into sporulation is critical for fungi to ensure survival of unfavorable environmental conditions. Here we present an analysis of gene sets regulating sporulation in the homothallic ascomycete Ashbya gossypii. Deletion of components of the conserved pheromone/starvation MAP kinase cascades, e.g., STE11 and STE7, results in increased sporulation. In kar3 mutants

Optical mapping (OM) has been used in microbiology for the past 20 years, initially as a technique to facilitate DNA sequence-based studies; however, with decreases in DNA sequencing costs and increases in sequence output from automated sequencing platforms, OM has grown into an important auxiliary tool for genome assembly and comparison. Currently, there are a number of new and exciting applicati

Stem cell lines that provide a renewable and scaleable supply of central nervous system cell types would constitute an invaluable resource for basic and applied neurobiology. Here we describe the generation and long-term expansion of multiple human foetal neural stem (NS) cell lines in monolayer culture without genetic immortalization. Adherent human NS cells are propagated in the presence of epid

https://www.ludc.lu.se/research/glucose-transport-and-protein-trafficking - 2026-07-15

https://www.ludc.lu.se/resources/flow-cytometry-core-facility-ludc/instruments - 2026-07-15

The possibility to manufacture hematopoietic stem cells (HSCs) in the laboratory would provide an indefinite source of cells for patients requiring bone marrow transplantation. Moreover, combined with the progress in gene editing techniques, it would provide a novel platform for gene and cell replacement therapies for a range of currently incurable congenic and acquired disorders. During my PhD, I

Microsoft Word - Lund-Dayeh-Abstract.docx Nanoscale Solid‐State Devices for Physiological Interfaces Shadi A. Dayeh Integrated Electronics and Biointerfaces Laboratory Department of Electrical and Computer Engineering University of California San Diego sdayeh@ucsd.edu The development of nanotechnologies that can provide high spatiotemporal resolution in monitoring electrophysiological activity can

https://www.nano.lu.se/sites/nano.lu.se/files/lund_dayeh_abstract.pdf - 2026-07-16

Bacterial movement in confined spaces is routinely encountered either in a natural environment or in artificial structures. Consequently, the ability to understand and predict the behavior of motile bacterial cells in confined geometries is essential to many applications, spanning from the more classical, such as the management complex microbial networks involved in diseases, biomanufacturing, min

Optimisation of cultivation conditions in the industrial production of probiotics is crucial to reach a high-quality product with high probiotic functionality. The production process includes a fermentation step to produce biomass, accompanied by centrifugation to concentrate the cells. Subsequently, the cells are treated with stabilising solutions (lyoprotectants) before they are subjected to fre

In contrast to mature cardiomyocytes which have limited regenerative capacity, pluripotent stem cells represent a promising source for the generation of new cardiomyocytes. The tendency of pluripotent stem cells to form teratomas and the heterogeneity fromvarious differentiation stages and cardiomyocyte cell sub-types, however, are major obstacles to overcome before this type of therapy could be a