Filetype
In situ growth rates of the toxin-producing dinoflagellate Dinophysis norvegica collected in the central Baltic Sea were estimated during the summers of 1998 and 1999. Flow cytometric measurements of the DNA cell cycle of D. norvegica yielded specific growth rates (μ) ranging between 0.1 and 0.4 per day, with the highest growth rates in stratified populations situated at 15–20 m depth. Carbon upta
Cancer cells are defined by their ability to invade through the basement membrane, a critical step during metastasis. While increased secretion of proteases, which facilitates degradation of the basement membrane, and alterations in the cytoskeletal architecture of cancer cells have been previously studied, the contribution of the mechanical properties of cells in invasion is unclear. Here, we app
Type 1 conventional dendritic cells (cDC1s) are rare immune cells critical for the induction of antigen-specific cytotoxic CD8+ T cells, although the genetic program driving human cDC1 specification remains largely unexplored. We previously identified PU.1, IRF8, and BATF3 transcription factors as sufficient to induce cDC1 fate in mouse fibroblasts, but reprogramming of human somatic cells was lim
Segmental gain of chromosome 17q is the most common genetic aberration in high-risk neuroblastoma, but its role in disease progression is poorly understood. This study aims to address the contribution of 17q gain to neuroblastoma malignancy. We analyzed the genetic and transcriptional landscape of 417 neuroblastoma patients across various risk groups and clinical stages using multi-omic approaches
Acoustofluidics utilizes a combination of acoustics, in the form of ultrasound, and microfluidics to manipulate cells and particles. This has proven to be a versatile method that is gentle to the cells. In this thesis acoustofluidics has been used for processing rare cells in continuous flow. Rare cells are within this thesis defined as cells that are present in numbers of 1-1000 per mL in a much
Myeloid Biomarkers and Immunotherapy group Our research focuses on the role of myeloid cells within the tumour microenvironment and strategies to modulate their functional activities. Tumour-infiltrating myeloid cells represent a highly heterogeneous population, including distinct subtypes and cellular states of macrophages, dendritic cells, monocytes, and granulocytes. These cells exhibit diverse
https://www.immun.lth.se/research/research-groups/malin-lindstedt - 2026-07-11
Microsoft Word - Hydrosolidarity 2012-13Researchers.docx Welcome to the final seminar: Hydrosolidarity - the Quest for better Water management in the Nile Basin The seminar takes place at the Pufendorf institute, main lecturehall, on the 29th of May 2013 between 9.00 - 17.00. All are welcome, but please note that seats are limited and registration necessary. For participation, please register here
https://www.pi.lu.se/sites/pi.lu.se/files/hydrosolidarity_2012-13_symposium.pdf - 2026-07-12
This report summarises our efforts in deriving, characterising and banking of 20 different human embryonic stem cell lines. We have derived a large number of human embryonic stem cell lines between 2001 and 2005. One of these cell lines was established under totally xeno-free culture conditions. In addition, several subclones have been established, including a karyoptypical normal clone from a tri
The ability to sense the surrounding environment and respond to external fluctuations is a fundamental property of cells, the basic unit of life. Although cells can be very different in their composition and structure, they all have specialized molecular mechanisms that allow them to adapt to their environment, by coordinating gene expression and protein production. In this thesis, we focus on a s
OBJECTIVES: Ghrelin, an endogenous ligand of the growth hormone secretagogue receptor (GHS-R), was recently identified in the stomach. Ghrelin is produced in a population of endocrine cells in the gastric mucosa, but expression in intestine, hypothalamus and testis has also been reported. Recent data indicate that ghrelin affects insulin secretion and plays a direct role in metabolic regulation an
Hematopoietic stem cells (HSCs) are safeguarded from various threats such as stress, injury, or radiationwithin specialized microenvironments or niches within the bone marrow. In this thesis, we investigatedvarious facets of the bone marrow (BM) microenvironment and its critical role in hematopoiesis andrelated disorders.Initially, we elucidated the role of the Early Growth Response 1 (EGR1) gene
Three-dimensional neuronal culture systems such as spheroids, organoids, and assembloids constitute a branch of neuronal tissue engineering that has improved our ability to model the human brain in the laboratory. However, the more elaborate the brain model, the more difficult it becomes to study functional properties such as electrical activity at the neuronal level, similar to the challenges of
Long non-coding RNAs (lncRNAs) are involved in breast cancer pathogenesis through chromatin remodeling, transcriptional and post-transcriptional gene regulation. We report robust associations between lncRNA expression and breast cancer clinicopathological features in two population-based cohorts: SCAN-B and TCGA. Using co-expression analysis of lncRNAs with protein coding genes, we discovered thre
