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In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program
High-grade serous ovarian cancer (HGSOC) is a major health concern for women due to its subtle onset, aggressive progression, high recurrence rate, and resistance to standard therapies. Olaparib, a PARP inhibitor, is currently used as maintenance therapy following removal of tumors. C26A6 is a promising therapeutic which has been shown to inhibit breast cancer progression in mouse models by disrup
Background/objectives: Mycosis fungoides (MF) is a rare malignancy, with an indolent course in the early stages of the disease. However, due to major molecular and clinical heterogeneity, patients at an advanced stage of the disease have variable responses to treatment and considerably reduced life expectancy. Today, there is a lack of specific markers for the progression from early to advanced st
Background: Expression of CD25, the IL-2 receptor alpha chain, on human mast cells is primarily associated with aberrant mast cells in clonal mast cell disorders. However, the regulation of CD25 expression in normal, mature tissue-resident mast cells remains poorly understood. Objective: IL-33 is a key modulator of immune responses, including in lung inflammatory conditions. Because mast cells are
The earliest stages of natural killer (NK) cell development are not well characterized. In this study, we investigated in different fetal hematopoietic tissues how NK cell progenitors and their mature NK cell progeny emerge and expand during fetal development. Here we demonstrate, for the first time, that the counterpart of adult bone marrow Lin(-)CD122(+)NK1.1(-)DX5(-) NK cell progenitor (NKP) em
Popular Abstract in English Look around and notice how many items have been manufactured or transported using petroleum-based products. In modern life, it is almost an impossible task to exclude them from our daily routine. They are present in plastics, cosmetics, cleaning products, medicaments, food, etc. To diminish our dependence on the demanded black liquid, a lot of research efforts have beenDepletion of easily accessible fossil energy resources, threat of climate change and political priority to achieve energy self-sufficiency and sustainable solutions prioritize a conscious and smart use of renewable resources to generate a bio-based economy. Bio-based compounds can replace chemicals and fuels that are now mainly produced from crude oil. Efficient processes for the conversion of pla
1 1 Application CARES school Invitation to all PhD students in cancer research at Lund University and University of Gothenburg to apply to become a research fellow in the new CARES program 2025-2026 The Cancer Research South (CARES) school was initiated in 2014 with support from the Swedish Cancer Society. The research school was relaunched in a new format, starting in January 2022. The new CARES
https://www.lucc.lu.se/internal/sites/lucc.lu.se.internal/files/2024-09/Application%20CARES%202025.docx - 2026-07-11
The functional decline of hematopoietic stem cells (HSCs) with age is a well-documented phenomenon, associated with various health complications, including anemia, impaired immune responses, and chronic inflammation. This dysfunction can contribute to the onset of hematological disorders such as myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia (CMML), and acute myeloid leukemia (AML
A Ph.D. Interview with Anna Konturek-Ciesla Anna Konturek-Ciesla successfully defended her Ph.D. thesis earlier this fall, on October 27, 2023. Her work was focused on understanding blood cell development, the process known as hematopoiesis, during chronological aging. With a keen interest in improving human health span, Anna has spent the last four years researching the mechanisms involved in age
https://www.stemcellcenter.lu.se/PhD%20Interview%20with%20Anna%20Konturek-Ciesla - 2026-07-09
RNA sequencing (RNAseq) methodology has experienced a burst of technological developments in the last decade, which has opened up opportunities for studying the mechanisms of adaptation to environmental factors at both the organismal and cellular level. Selecting the most suitable experimental approach for specific research questions and model systems can, however, be a challenge and researchers i
