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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 113615 hits

Detection of SARS-CoV-2 by rapid antigen tests on saliva in hospitalized patients with COVID-19

Background: The COVID-19 pandemic presents great challenges on transmission prevention, and rapid diagnosis is essential to reduce the disease spread. Various diagnostic methods are available to identify an ongoing infection by nasopharyngeal (NPH) swab sampling. However, the procedure requires handling by health care professionals, and therefore limits the application in household and community s

Anxiety, depression and quality of life in relation to SARS-CoV-2 antibodies in individuals living with diabetes during the second wave of COVID-19

Aims: The objective was to compare anxiety, depression, and quality of life (QoL) in individuals living with type 1 (T1D) and type 2 (T2D) diabetes with matched controls during the second wave of the COVID-19 pandemic. Methods: Via randomization, individuals living with diabetes T1D (n = 203) and T2D (n = 413), were identified during February-July 2021 through health-care registers. Population con

Aggregation and toxicity study of Parkinson’s Disease related mutations in α-Synuclein.

Parkinsons sjukdom är en neurologisk sjukdom som drabbar upp till 2 % av alla människor över 60 år. De exakta orsakerna som leder till utvecklingen av sjukdomen är fortfarande okända men åldrandet är den största kända riskfaktorn idag. Sjukdomen kännetecknas av en progressiv försämring av kroppens rörelseförmåga i samband med förlust av nervceller. Patienter med sjukdomen har också påvisat proteinParkinson´s Disease is the second most common neurodegenerative disease. Only a small number of cases appear to be caused by genetic mutations, meaning most cases arise due to unknown mechanisms. While there are reported to be multiple causes of the disease, what links all cases is a small protein called α-synuclein whose aggregation appears to correlate to the pathology and progression of the dis

Neuropathy-related mutations alter the membrane binding properties of the human myelin protein P0 cytoplasmic tail

Schwann cells myelinate selected axons in the peripheral nervous system (PNS) and contribute to fast saltatory conduction via the formation of compact myelin, in which water is excluded from between tightly adhered lipid bilayers. Peripheral neuropathies, such as Charcot-Marie-Tooth disease (CMT) and Dejerine-Sottas syndrome (DSS), are incurable demyelinating conditions that result in pain, decrea

Molecular and Serologic Diagnostic Technologies for SARS-CoV-2

The COVID-19 pandemic has presented many challenges that have spurred biotechnological research to address specific problems. Diagnostics is one area where biotechnology has been critical. Diagnostic tests play a vital role in managing a viral threat by facilitating the detection of infected and/or recovered individuals. From the perspective of what information is provided, these tests fall into t