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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 193297 hits

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A polyacrylamide gel crosslinked with allyl-b-cyclodextrin can be used repeatedly for several weeks for the separation of DNA fragments, since bubbles are not generated during a run. Allyl-b-cyclodextrin can easily be synthesized in one step from allylglycidylether and b-cyclodextrin. The plate numbers for DNA fragments, up to about 1500 bp, are high: for the 21 separation of pBR322/HaeIII fragmen

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Coronary heart disease (CHD) development is associated to a combination of lifestyle and genetic factors. A number of lifestyle risk factors is well defined, while genetic factors have not yet been well determined.

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OBJECTIVE: To analyse the outcome of minor amputations (through, or distal to, the ankle joint) in patients with diabetes. METHOD: All diabetic patients in a defined population undergoing one or more minor amputation between 1982 and 2006 were investigated according to a standardised protocol and were followed until final outcome (healing or death). A total of 410 consecutive amputations in 309 p

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Background: Earlier analyses within the EPIC study showed that dietary fibre intake was inversely associated with colorectal cancer risk, but results from some large cohort studies do not support this finding. We explored whether the association remained after longer follow-up with a near threefold increase in colorectal cancer cases, and if the association varied by gender and tumour location. Me

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The reactions between chalcocite, synthetic copper(I) sulfide, acanthite and synthetic silver(I) sulfide, and aqueous and acetone solutions of potassium ethylxanthate have been studied. Qualitative analysis of the ethylxanthate species present on the surfaces of the sulfide minerals and the synthetic metal sulfides has been made by means of diffuse reflectance infrared Fourier transform (DRIFT) sp

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Background and purpose: Cone Beam Computed Tomography (CBCT) based online adaptive radiotherapy (oART) has been clinically implemented for several anatomical sites worldwide. However, random and abrupt anatomical changes with large density alterations can occur in lung patients, leading to uncertainties with synthetic computed tomography (sCT) and dose calculation. The anatomical changes could be

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Horisonter med subfossila stubbar och rötter av tall (Pinus sylvestris) är vanliga i stratigra-fier från torvmarker i norra Europa. Dessa är tydliga indikationer på att det under holocen funnits perioder med tillräckligt gynnsamma förhållanden för tallar att växa på mossar. Tall kan endast växa på mossar när ytan är tillräckligt torr, och därför är rester av tallar på mossar goda indikationer på eHorizons rich in subfossil stumps and roots of Scots pine (Pinus sylvestris) are frequently found in stratigraphies of northern European peatlands, providing clear evidence of Holocene periods with favourable conditions for bog-pine growth. The pines could only grow when bog-surface wetness was sufficiently low, and the presence of their remains is therefore a good indicator of past climatic condi

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Losses of both habitat area and connectivity have been identified as important drivers of species richness declines, but little theoretical and empirical work exists that addresses the effect of fragmentation on relative commonness of highly mobile species such as pollinating insects. With a large dataset of wild bee and butterfly abundances collected across Europe, we first tested the effect of h

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Introduction: Observational studies have shown that glycated haemoglobin (HbA(1c)) is related to mortality, but the shape of the association is less clear. Furthermore, disease duration and medication may modify this association. This observational study explored the association between HbA(1c) measured in stored erythrocytes and mortality. Secondly, it was assessed whether disease duration and me

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A major concern in common disease epigenomics is distinguishing causal from consequential epigenetic variation. One means of addressing this issue is to identify the temporal origins of epigenetic variants via longitudinal analyses. However, prospective birth-cohort studies are expensive and time consuming. Here, we report DNA methylomics of archived Guthrie cards for the retrospective longitudina

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Context: Nonfasting (postprandial) triglyceride concentrations have emerged as a clinically significant cardiovascular disease risk factor that results from accumulation of remnant triglyceride-rich lipoproteins (TRLs) in the circulation. The remnant TRLs are cleared from the circulation by hepatic uptake, but the specific mechanisms involved are unclear. The syndecan-1 heparan sulfate proteoglyca

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The current study aimed to investigate what motivational effects Leader Autonomy Support (LAS), frequency of competitions and competitive climate have on employees within retail. A total of 350 stores were approached with an online survey, collecting answers from 64 retail employees (N=64). The hypotheses that LAS would have a significant association with intrinsic motivation was confirmed. Cooper

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SAMMANFATTNING Målet med examensarbetet är att designa en värdig byggnad för icke-religiösa ceremonier och göra en djupdykning i hur arkitekturen kan skapa en högtidlig upplevelse. Byggnaden, Tegelgläntan, kommer att uppföras i Slottsskogen i Göteborg där Observatoriet ligger idag. Arbetet kan grovt delas in i tre delar: bakgrundsanalys, platsanalys och gestaltning. Bakgrundsanalysen gjordes genABSTRACT The purpose of this thesis is to design a building worthy of non-religious ceremonies and to explore how architecture can create a ceremonious experience. The building, Tegelgläntan, is to be built in Slottsskogen in Gothenburg, Sweden. Today the location hosts an old observatory. The thesis can roughly be divided into three parts, background research, location analysis and design proces

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The successive waves of violence since May 2012, have put Myanmar in the international spotlight. The crisis in the Rakhine state has quickly become a global concern broadly discussed in the media. This paper examines how the Rohingya crisis is framed in Burmese and Western news media agencies by comparing the media coverage by The Global New Light of Myanmar and The New York Times between 2017-08