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Aim: To determine how species richness gradients—commonly considered universal—vary across the phylogenetic hierarchy of birds and mammals, and to uncover how clade age and size predetermine the gradients. Location: Global. Time Period: Last 120 million years. Taxa Studied: Birds and mammals (~15,000 species). Methods: We used large-scale phylogenies of birds and mammals and captured the species r
Background & Aims: Biomarkers are needed to identify individuals at elevated risk of inflammatory bowel disease. This study aimed to identify protein signatures predictive of inflammatory bowel disease. Methods: Using large population-based cohorts (n ≥180,000), blood samples were obtained from individuals who later in life were diagnosed with inflammatory bowel disease and compared with age a
Objective: Low-carbohydrate, high-fat diets under eucaloric conditions are associated with several health-beneficial metabolic effects in humans, particularly in the liver. We recently observed that apolipoprotein A-IV (apoA-IV), a highly abundant apolipoprotein, was among the most upregulated proteins in circulation after six weeks of consuming a high-fat diet in humans. However, the impact of di
Tackling biodiversity loss requires not only scaling up financial resources but also improving the governance of how such resources are mobilized, allocated, and accounted for. This paper reviews recent peer-reviewed literature (2019–2023) on biodiversity finance governance, focusing on three interrelated themes: financial instruments and mechanisms, governance structures, and critical and normati
Background and Aims: Population-based data on prescribed opioid use among adults with Crohn's disease (CD) remain limited. Methods: This nationwide register-based study included individuals ≥ 18 years with incident (2008–2019) or prevalent (2008–2021) CD and up to 10 individually matched reference individuals without inflammatory bowel disease. We categorised opioid dispensations as weak (e.g., tr
Globally, freshwater ecosystems are threatened by multiple stressors, yet our knowledge of how they interact to affect food web structure remains scant. To address this knowledge gap, we conducted a large-scale mesocosm experiment to quantify the single and combined effects of three common anthropogenic stressors: warming, increased nutrient loading, and insecticide pollution, on the network struc
Purpose: The aim of this study was to evaluate bony fusion with Low Dose CT (LDCT) over time following posterior scoliosis surgery in an all screw construct in patients with AIS with special focus on whether the spinal fusion process continue to develop beyond 2 years after scoliosis surgery and to evaluate if LDCT is an adequate radiological method to assess fusion maturation. Methods: Twenty fiv
External quality assessment (EQA) schemes for pathology are essential, yet large/international programmes do not assess morphology-based biomarkers or address local/regional needs. This study outlines bottom-up initiated, flexible Swedish Digital Pathology EQA rounds for breast pathology, and presents results from the 2021 and 2023 rounds. Six breast carcinoma cases were selected for each EQA roun
Background: The growing challenges of population aging create a pressing need for specialized geriatric medicine services to effectively address the complex health needs of older adults and influence supportive healthcare policies. Older patients may present clinical complexity with multimorbidity, disability, and/or frailty, necessitating a shift from the traditional organ-oriented clinical appro
This systematic literature review assesses the current state of knowledge on how increased ICT use affects individual time-use patterns and the associated implications for lifestyle climate implications. While the environmental impacts of ICT have been widely debated in terms of direct energy consumption, there has been limited focus on the indirect time-use effects. The review draws on 101 articl
Objective To systematically review and synthesise the incidence and characteristics of injuries and illnesses among athletes participating in the Olympic, Youth Olympic and Paralympic Games.Design Systematic review and meta-analysis.Data sources PubMed, Embase, CINAHL, Scopus and Web of Science were searched up to 2 July 2024, and Google Scholar, ClinicalTrials.gov and WHO International Clinical T
Glycopolymers are versatile materials for biomedical and healthcare applications, e.g., as carrier and polymeric therapeutics. Especially, the topology and surface composition of such materials play a key role in being promising materials in the anti-amyloidogenic interventions. Herein, 2nd and 3rd generation of pseudo-glycodendrimers (PGDs), based on hyperbranched polyester core with different su
Purpose: The study explores how organizational space and situational strength influence bystanders’ intentions to intervene in workplace bullying within the healthcare sector. Design/methodology/approach: The research employs vignette-based interviews with 24 healthcare professionals from various medical fields in Sweden. The vignettes depict different bullying scenarios occurring in various spati
BACKGROUND: Multidrug resistant Acinetobacter baumannii remains a global concern with its ability to adhere, disperse and sustain in areas involving suboptimal infection control measures, particularly in war areas. In this study we aimed to evaluate the susceptibility profiles, molecular epidemiology and pathogenesis of A. baumannii isolates from conflict zones in Ukraine.METHODS: A. baumannii wou
Insulin secretion from vesicles within pancreatic beta cells occurs through the rapid (≤10 ms) process of exocytosis. A crucial final step in this process is the formation of a fusion pore, which connects the insulin vesicle interior to the extracellular space and insulin secretion rate. We employed real-time single-cell amperometry (SCA) with microsensors to quantitatively and dynamically monitor
Jaboticaba (Plinia jaboticaba) is an underutilized Brazilian berry and a source of dietary fiber, cyanidin-3-O-glucoside, and ellagic acid derivatives. Non-clinical studies have shown the potential of jaboticaba to alleviate insulin resistance, low-grade inflammation, and obesity-related cognitive decline, although clinical evidence remains limited. A clinical study was conducted to investigate wh
Introduction: Falls among hospitalized older adults increase morbidity, prolong hospital stays, and raise healthcare costs. Sensor-based technologies and medical devices are emerging tools for fall prevention, but their clinical effectiveness remains uncertain. This systematic review aimed to assess their effectiveness in reducing inpatient falls, staff workload, and physical restraint use in hosp
MicroRNAs (miRNAs) are pivotal post-transcriptional regulators that orchestrate gene expression programs governing cancer initiation, progression, metastasis, and therapeutic resistance. Among their many targets, the WNT signaling pathway, a key driver of malignancy, is tightly controlled by miRNAs, forming intricate feedback loops that shape tumor behavior. Concurrently, flavonoids, naturally occ
Gastrointestinal (GI) cancers, including esophageal, gastric, pancreatic, liver, and colorectal malignancies, represent a major global health burden due to their high incidence, aggressive nature, and limited treatment outcomes. This review explores the therapeutic potential of carvacrol, a naturally occurring monoterpenoid phenol predominantly found in oregano and other aromatic plants. Carvacrol
Inhibition of adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) is under increasing investigation for its therapeutic potential in many diseases. Existing AMPK inhibitors are however limited, with poor selectivity and substantial off-target effects. Here, we provide mechanistic insights and describe the cellular selectivity of the recently identified AMPK inhibitor BAY-3827. A 2.5-Å
