Filetype
Background There is a great need for a simple and clinically useful instrument to help physicians estimate the probability of survival to discharge with a good neurological outcome (cerebral performance category, CPC = 1) in cases of in-hospital cardiac arrest (IHCA). Our aim was to validate the “Good Outcome Following Attempted Resuscitation” (GO-FAR) score in a different country with different d
Importance: The role of ω-3 polyunsaturated fatty acids for primary prevention of coronary heart disease (CHD) remains controversial. Most prior longitudinal studies evaluated self-reported consumption rather than biomarkers. Objective: To evaluate biomarkers of seafood-derived eicosapentaenoic acid (EPA; 20:5 ω-3), docosapentaenoic acid (DPA; 22:5 ω-3), and docosahexaenoic acid (DHA; 22:6 ω-3) an
Background/Objectives:The incidence of microscopic colitis (MC) has increased over the previous decades. In addition to smoking and drugs, currently unidentified environmental factors may have a role. The aim of this study was to determine whether specific dietary or other lifestyle factors were associated with the development of MC.Subject/Methods:The population-based cohort Malmö Diet and Cancer
Background: Whether and how n-3 and n-6 polyunsaturated fatty acids (PUFAs) are related to type 2 diabetes (T2D) is debated. Objectively measured plasma PUFAs can help to clarify these associations. Methods and Findings: Plasma phospholipid PUFAs were measured by gas chromatography among 12,132 incident T2D cases and 15,919 subcohort participants in the European Prospective Investigation into Canc
Conclusion: The data indicate important roles for phosphodiesterase (PDE) 3, 4, 5, and related cAMP and cGMP pools in the regulation of inner ear fluid homeostasis. Thus, dysfunction of these enzymes might contribute to pathologies of the inner ear. Objective: The mechanisms underlying endolymphatic hydrops, a hallmark of inner ear dysfunction, are not known in detail; however, altered balance in
Background: Migraine and Cluster Headache (CH) are two primary headaches with severe disease burden. The disease expression and the mechanisms involved are poorly known. In some attacks of migraine and in most attacks of CH, there is a release of vasoactive intestinal peptide (VIP) originating from parasympathetic cranial ganglia such as the sphenopalatine ganglion (SPG). Patients suffering from t
The rising prevalences of type 2 diabetes and obesity constitute major threats to human health globally. Powerful social and economic factors influence the distribution of these diseases among and within populations. These factors act on a substrate of individual predisposition derived from the composite effects of inherited DNA variation and a range of environmental exposures experienced througho
Purpose Systemic lupus erythematosus (SLE) is a predominantly female autoimmune disease that can affect the central nervous system. Neuropsychiatric symptoms are found in 25–70% of SLE patients. Using diffusion tensor imaging, various studies have reported changes in white matter integrity in SLE patients with neuropsychiatric symptoms (NPSLE patients). The purpose of this study was to investigate
The amphipod species Haploops tubicola has an unusual compound eye that is divided into three separate parts, each with one common cuticular lens. The dorso-frontal eyepair has, in addition to the lens, a so-called vitreous body, which is constructed like a dioptric lens and is inserted in the ray-path. The ‘vitreous body’ is actually — and for which evidence is presented — a secretory product for
Randomized controlled trials (RCT) are often underpowered for validating gene-treatment interactions. Using published data from the Diabetes Prevention Program (DPP), we examined power in conventional and genotype-based recall (GBR) trials. We calculated sample size and statistical power for gene-metformin interactions (vs. placebo) using incidence rates, gene-drug interaction effect estimates and
Abstract in Italian Questo articolo tratta del ruolo importante che il sistema Ghent ed altre caratteristiche delle relazioni industriali in Svezia rivestono nel mantenimento di alti livelli di densità sindacale in Svezia. Il governo di centro-destra, insediatosi in seguito alle elezioni parlamentari nel settembre 2006, nel 2007 ha introdotto o tentato di introdurre modifiche sostanziali nelle ass
How to judge religions other than one’s own when facing a plurality of religions? The author makes a philosophical inquiry in two interconnected fields, linguistic undecidability and the necessity of making judgements. The central claim is that no stable centre for meaning can be established for linguistic entities. Even in cases where a stable centre of meaning would seem to be required, the auth
Popular Abstract in Swedish Växternas respirationskedja innehåller protonpumpande enzymer, som konserverar energi i form av en protongradient, samt alternativa icke-protonpumpande enzymer. I det mitokondriella innermembranet finns ett protonpumpande NADH dehydrogenas, komplex I, och alternativa typ II NAD(P)H dehydrogenaser som kan oxidera NADH och NADPH från matrixen eller cytosolen. I ArabidopsiThe respiratory chain of plants contains both proton-pumping enzymes that conserve energy and non-proton-pumping alternative enzymes that bypass the sites of energy conservation. In addition to the proton-pumping complex I, plant mitochondria contain alternative type II NAD(P)H dehydrogenases, which allow oxidation of NADH and NADPH from the matrix and the cytosol. The seven gene homologues of typ
Abstract: Reference pollen data for use in interpreting fossil pollen assemblages may be either collected as surface samples or monitored by means of pollen traps. Surface samples can be obtained from moss polsters or lake-surface sediment, or exceptionally soil, leaf litter, or snow. The advantage of such samples is that a large number can be collected relatively quickly. Within the resulting pol
Abstract in Uncoded languages achtergrond De incidentie van schizofrenie bij migranten lijkt verhoogd. doel Kwantificeren van het risico op schizofrenie bij migratie. methode Meta-analyse van Engelstalige publicaties over incidentieonderzoeken uit de periode 1977-2003. resultaten Het gemiddelde, gewogen relatieve risico (rr) van schizofrenie was 2,7 (95%- betrouwbaarheidsinterval (bi) 2,3-3,2) voobackground There is evidence of an increased incidence of schizophrenia in immigrants. aim To provide a quantitative index of the effect size associated with immigration. method We performed a meta-analysis of English-language incidence studies that were published between 1977 and 2003. results The mean, weighted relative risk (rr) was 2.7 (95%- confidence interval (ci) 2.3- 3.2) for first-generat
Weight loss improves insulin sensitivity and glucose tolerance in obese subjects with impaired glucose tolerance (IGT), but the long term dynamic effects on blood metabolites other than glucose during an oral glucose tolerance test (OGTT), are largely unknown. Here, we studied changes in OGTT-elicited metabolite patterns in obese subjects during a diet-induced weight loss study.
We compared, head-to-head, the old generation Actigraph model 7164 with the new generation Actigraph GT1M accelerometer. A total of 15 randomly selected teenagers (eight girls and seven boys) were investigated. They performed a treadmill test wearing the two kinds of accelerometers around the waist simultaneously. The treadmill test consisted of three different levels of speed 4, 6 and 8 km h(-1)
