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Background: Generating parasite genomes is challenging when little of the DNA in infected host tissue is from the parasite. We used selective whole genome amplification (SWGA) to generate genomic data from wildlife samples of the avian haemosporidian Haemoproteus majoris (lineage PARUS1) and its host, the blue tit (Cyanistes caeruleus). Methods: We used SWGA to amplify the parasite DNA in nine avi
Objective: Although rare, malignant ovarian germ cell tumors (MOGCTs) account for 70 % of ovarian malignancies in women younger than 30 years. Given the rarity of MOGCTs and the limited population-based data, this study aims to examine national treatment patterns and survival in women with MOGCTs, with a focus on fertility-sparing surgery. Methods: This nationwide population-based study included a
Aim Habitual physical activity (PA) affects metabolism and homeostasis in various tissues and organs. However, detailed knowledge of associations between PA and cardiovascular disease (CVD) risk markers is limited. We sought to identify associations between accelerometer-assessed PA classes and 183 proteomic and 154 metabolomic CVD-related biomarkers. Method We utilized cross-sectional data from t
Relapse and treatment resistance are common in children with high-risk neuroblastoma, and novel therapies are needed. Conventional drug discovery is slow, expensive, often fails in practice, and consequently falls short in addressing pediatric and rare conditions. In such instances, drug repurposing is a promising strategy. Here, we used two independent in silico prediction tools including machine
Pesticide use and habitat loss are major anthropogenic drivers of bee decline, raising global concerns about impaired crop pollination. However, the relative importance of these stressors and their combined impact on bee assemblages comprising species with different traits, such as body size or nesting strategy, remains unknown. Here we addressed these key knowledge gaps in a global quantitative s
Background: Plasma phosphorylated tau217 (p-tau217) is a robust biomarker of Alzheimer's disease (AD) pathology. However, its full potential as a dynamic marker has still not been verified in very old persons, i.e., those with the highest incidence of AD. Objective: To examine the cross-sectional and longitudinal associations between plasma p-tau217 concentration and cerebrospinal fluid (CSF) AD b
Urbanization in coastal megacities leads to trade-offs between development and ecology, degrading carbon sinks and disrupting spatial-functional balance. Current models often fail to integrate land use, carbon dynamics, and ecological zoning. This study created a system that brings together Patch-generating Land Use Simulation (PLUS), Integrated Valuation of Ecosystem Services and Trade-offs (InVE
Cardiovascular disease is the global number one causeof mortality and morbidity. The majority of cardio vascular diseases are caused by atherosclerosis, a lipid-driven, inflammatory disease of the middle- and large-sized arteries. The disease is characterized by the formation of atherosclerotic plaques throughout the arterial tree. Over the years, insights intohe pathogenesis of atherosclerosis ha
Background Patients with acute coronary syndrome (ACS) are often admitted to monitored wards due to the risk of complications. Several risk prediction scores exist, but their use in the emergency department (ED) is limited. We aimed to compare the ability of existing risk scores with a new logistic regression model in predicting complications in ACS patients. Methods This was a secondary analysis
Objectives This study evaluates the cost-effectiveness of rechargeable (RC) and nonrechargeable, primary cell (PC) traditional and multimodal spinal cord stimulation (SCS) systems in combination with conventional medical management (CMM) compared with CMM alone in patients with persistent spinal pain syndrome type 2 (PSPS-2) with low back/leg pain that remains despite surgery. Material and Methods
The emergence of large language models (LLMs) has made it easier than ever to create chatbots capable of generating human-like responses to user inputs. Moreover, improvements in text-to-speech and speech-to-text make it possible to converse with these systems, not just in text but also through speech. These improvements have led to an increase in chatbot applications across various contexts, such
Understanding metabolic processes of soil fungi is essential for elucidating their ecological roles in biogeochemical cycles and responses to emergent environmental stressors. Here, we demonstrate the potential of using stable isotope probing Raman (SIP-Raman) microspectroscopy in microfluidics technology-based soil chips to trace glucose metabolism rates and stress responses in laboratory grown f
The work developed within Following the Fish—an artistic research project exploring architecture, migration and collective practice through workshop-based methodologies—was presented at the Venice Architecture Biennale 2023 (20 May – 26 November 2023), one of the most significant international exhibitions of contemporary architecture, as part of the Catalan representation.The exhibition brought to
Following the Fish—an artistic research project exploring architecture, migration and collective practice through workshop-based methodologies—was presented in 2024 as part of the exhibition UnFold: Exploring Artistic Directions in Architectural Research at Lund University.The project was developed through a series of workshops across Barcelona, Lund and Venice, engaging with the spatial and socia
BACKGROUND: The major pathways contributing to cardiovascular disease among night shift workers remain poorly understood. MicroRNAs (miRNAs) have been identified as novel regulators of cardiovascular risk factors. Our objective was to examine whether night shift work was associated with altered expression of five cardiovascular-related miRNAs in night and day shift workers.METHODS: RNA was extract
Cash transfer programs have been shown to be a successful tool in reducing poverty by multinational impact analysis. However, if they are able to affect gender dynamics remains a debated topic. Critics claim that the programs may reinforce traditional gender roles whilst others mean that increasing women’s income with a cash transfer is empowering. This study investigates the Child Support Grant i
This thesis aims to investigate the impact of domestic- and foreign monetary policy on stock returns of Swedish firms, currently listed at the Nasdaq Large Cap. Daily stock returns are regressed against FOMC- and Riksbank policy changes respectively on the day of their announcements, using a fixed effects model. Control variables and time dummies are included in the model to account for changing c
Climate change is one of the most significant challenges that building sector is confronting. For example, Climate change and associated extreme events are posing a significant challenge for the building sector. Buildings should be prepared to withstand the climate changes and extreme weather that will happen in the future. Designing buildings based solely on past or average weather conditions, wh
