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Background: For decades, early allogeneic stem cell transplantation (HSCT) has been used to slow neurological decline in metachromatic leukodystrophy (MLD). There is lack of consensus regarding who may benefit, and guidelines are lacking. Clinical practice relies on limited literature and expert opinions. The European Reference Network for Rare Neurological Diseases (ERN-RND) and the MLD initiativ
Sustaining yields for smallholder perennial agriculture under a rapidly changing climate regime may require consideration of landscape features and on-farm management decisions in tandem. Optimising landscape and management may not be possible for maximising yields in any one year but maintaining heterogeneous landscapes could be an important climate adaptation strategy. In this study, we observed
PURPOSE: To investigate the effects of compartmental anisotropy on filtered exchange imaging (FEXI) in white matter (WM).THEORY AND METHODS: FEXI signals were measured using multiple combinations of diffusion filter and detection directions in five healthy volunteers. Additional filters, including a trace-weighted diffusion filter with trapezoidal gradients, a spherical b-tensor encoded diffusion
The concept of prefiguration has gained attention within environmental politics as a way to describe how everyday activism can enable transformation of unsustainable consumption practices, particularly around material necessities. Drawing on the case of Sweden’s flight-free movement, this article extends the research on prefigurative environmentalism to activism aimed at changing non-essential, ye
Solitary bees are important pollinators of crops and wild plants, and their decline poses a risk to the sustained provision of the services they provide. Although evidence suggests that exposure to insecticides can affect bees, most pesticide research and risk assessment has focussed on social bees and mortality while solitary species are understudied. The ability to forage is critical for solitar
The concept of prefiguration is drawing increasing interest as a lens to study the collective dynamic and transformative potential of alternative organizing. We introduce an analytical distinction between two modes of prefiguration. Situated prefiguration emphasizes affective bonds and direct struggle taking place in bounded organizational spaces, while distributed prefiguration manifests in wider
This chapter discusses Ilia Repin’s court commission, Reception of Volost Elders by Alexander III in the Courtyard of the Petrovsky Palace in Moscow (1886). It argues that the painting reflected marginalizing discourses on the non-Russian minorities dominant at the outset of Alexander III’s rule. Repin employed a differentiating approach to rendering ethnically and religiously diverse representati
White adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new generation of direct, small-molecule activators. AMPK a
We derive and validate an analytical model that describes the migration of Raman scattered photons in two-layer diffusive media, based on the diffusion equation in the time domain. The model is derived under a heuristic approximation that background optical properties are identical on the excitation and Raman emission wavelengths. Methods for the reconstruction of two-layer Raman spectra have been
The Paris agreement on climate change requires rapid reductions in greenhouse gas emissions. One important mitigation strategy, at least in the intermediate future, is the substitution of fossil fuels with bioenergy. However, using agriculture- and forest-derived biomass for energy has sparked controversy regarding both the climate mitigation potential and conflicts with biodiversity conservation.
Involving older people through co-design has become increasingly attractive as an approach to develop technologies for them. However, less attention has been paid to the internal dynamics and localized socio-material arrangements that enact this method in practice. In this paper, we show how the outcomes that can be achieved with user involvement often pertain to learning, but their content can di
Glucagon-like peptide 1 receptor agonist exenatide (exendin-4) has potential protective capabilities against diabetic kidney disease (DKD). However, the underlying mechanism has not been fully elucidated. The expression of thioredoxin-interacting protein (Txnip) is upregulated during DKD progression by histone acetylation. Sirtuin 1 (SIRT1) is a deacetylase and is decreased in DKD, which indicates
Whole-body glucose homeostasis is coordinated through secretion of glucagon and insulin from pancreatic islets. When glucose is low, glucagon is released from a-cells to stimulate hepatic glucose production. However, the mechanisms that regulate glucagon secretion from pancreatic a-cells remain unclear. Here we show that in a-cells, the interaction between fatty acid oxidation and glucose metaboli
Transformative change toward sustainability is increasingly recognized as inevitable to avoid the collapse of socio-ecological systems. However, for a deep and system-wide transformation, governance approaches and policymaking need to be changed too. This paper discusses how a diverse value approach in environmental policymaking could be undertaken to foster transformative governance that can furt
A report on the 1ST EASA Muslim Worlds Network workshop at the Swedish Research Institute, Istanbul, 7-8 September 2023
Scholarship addressing Shia Muslim minorities in Western contexts often refers to them as a ‘minority within a minority’ or ‘the other within the other,’ highlighting their dual-marginalization within non-Muslim societies. This paper challenges the concept of double-marginalization by examining the dynamics of transnational Shia communal spaces in north-west London and the creation of Shia spaces
Paediatric prospective studies of coeliac disease with longitudinal collection of biological samples and clinical data offer a unique perspective on disease risk. This Review highlights the information now available from international paediatric prospective studies on genetic and environmental risk factors for coeliac disease. In addition, recent omics studies have made it possible to study comple
