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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 194681 hits

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Abstract: Wood is an increasingly important material in the sustainable transition of societies worldwide. The performance of wood in structures is intimately tied to the presence of moisture in the material, which directly affects important characteristics such as dimensions and mechanical properties, and indirectly its susceptibility to fungal decomposition. By chemical modification, the durabil

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Vaccination could be an effective strategy for slowing the spread of the current coronavirus disease 2019 (COVID-19) pandemic. Vaccine hesitancy could pose a serious problem for COVID-19 prevention, due to the spread of misinformation surrounding the ongoing pandemic. The aim of this study was to assess the attitudes towards the prospective COVID-19 vaccines among the general public in Jordan, Kuw

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We report on pulse contrast characterization of the output of a gas-filled multi-pass cell employed for 20-fold compression of a high-power Yb:YAG laser. We demonstrate an energy content of 80% in the compressed fs pulse.

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Background and purpose: Neoadjuvant chemoradiotherapy (nCRT) is used in locally recurrent rectal cancer (LRRC) to increase chances of a radical surgical resection. Delineation in LRRC is hampered by complex disease presentation and limited clinical exposure. Within the PelvEx II trial, evaluating the benefit of chemotherapy preceding nCRT for LRRC, a delineation guideline was developed by an exper

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The Paris Agreement suggests that all countries engage in significant emission reductions. To stay within safe guardrails, usually defined as a maximum warming of 1.5 °C compared to pre-industrial times, this will mean decarbonisation within less than 30 years. This significant challenge is complicated because of growth in some sectors, such as tourism. This paper analyses emissions and economic o

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This investigation aims to obtain a thermosensitive platform useful for specific nanomedicine applications through the addition of suitable salts. An aqueous mixture consisting of the copolymer Pluronic F127 and sodium carboxymethyl-cellulose, in a ratio of 20/4 by weight, in the presence of different concentrations of Na2SO4, NaCl, and NaSCN, was investigated using the visual inversion tube appro

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Metaphrasis: A Byzantine Concept of Rewriting and Its Hagiographical Products represents a first and authoritative discussion of rewriting in Byzantium. It brings together a rich variety of articles that treat the topic of hagiographical rewriting from various angles.The contributors discuss and comment on different kinds of texts in Greek and other languages, including Apophthegmata Patrum, Passi

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The article presents a semantic theory suggesting that equivalence and polyvalence are closely connected phenomena. The connection between them is utilised by making equivalence the basis of an argument for polyvalence within semantics, or in other terms, for a stratified semantics encompassing two levels of description. This argument from equivalence lends new support to frameworks assuming a str

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Introduction: As people with haemophilia (PWH) receive better treatment and live longer they are more likely to encounter cardiovascular disease (CVD) and other comorbidities. ESC guidelines for the acute management of patients presenting with acute coronary syndrome (ACS) are based on the non-haemophilia population. Aim: To review the guidelines and propose relevant adaptations for PWHA without i

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Objective: The aim of this study was to examine women's experience of menopausal transition and their expectations and wishes for support from healthcare. Further, to examine their knowledge about menopause and thoughts about current attitudes in healthcare and in society generally. Methods: Data was collected through three focus group interviews with 14 women experiencing menopausal symptoms. The

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Why do certain countries display high gender equalities while others display low gender equalities? To what extent does gender equality foster economic growth and development? The past decade has witnessed a boom and increasing literature about the role played by women and gender in long-run economic development. The increasing awareness of economics and economic history have contributed to improv

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The orchid genera Catasetum employs a hair-trigger activated, pollen release mechanism, which forcibly attaches pollen sacs onto foraging insects in the New World tropics. This remarkable adaptation was studied extensively by Charles Darwin and he termed this rapid response "sensitiveness." Using high speed video cameras with a frame speed of 1000 fps, this rapid release was filmed and from the su

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Significant collaborations with research partners in China are seen in many Western countries. With increasing geopolitical tensions governments, research institutions and individuals are increasingly called upon to address a proliferating array of risks and challenges associated with scientific collaboration with China. The situation is characterised by two parallel, intertwined processes. On the

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A mid-century net zero target creates a challenge for reducing the emissions of emissions-intensive, trade-exposed sectors with high cost mitigation options. These sectors include aluminium, cement, chemicals, iron and steel, lime, pulp and paper and petroleum refining. Available studies agree that decarbonization of these sectors is possible by mid-century if more ambitious policies are implement

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Despite incredible progress in cancer treatment, therapy resistance remains the leading limiting factor for long-term survival. During drug treatment, several genes are transcriptionally upregulated to mediate drug tolerance. Using highly variable genes and pharmacogenomic data for acute myeloid leukemia (AML), we developed a drug sensitivity prediction model for the receptor tyrosine kinase inhib

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MUC5B is the predominant glycoprotein in saliva and is instrumental in the establishment and maintenance of multi-species eubiotic biofilms in the oral cavity. Investigations of the aciduric Lactobacillaceae family, and its role in biofilms emphasizes the diversity across different genera of the proteolytic systems involved in the nutritional utilization of mucins. We have characterized a protease

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Physical activities such as long-distance running can form a habit and might be related to drug-induced addictive behaviors. We investigated possible modulations of N-methyl-D-aspartate (NMDA) receptor subunits during voluntary wheel running in brain regions implicated in reward and addiction. It was observed that Lewis rats progressively increased their amount of daily running, reaching maximum l

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A dynamic model and simulation program describing the principles of a steam supply system for a paper dryer were developed. The dynamics of a cylinder and the paper sheet during an altered valve position were studied. The results showed that the dynamic course during a pressure increase is different from the course during a pressure decrease. A potential method for the determination of the heat tr