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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 193054 hits

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We have studied the adsorption of two silane compounds, (3-mercaptopropyl) trimethoxysilane (MPTMS) and n-propyltriethoxysilane (PTES), on a rutile TiO2(110) surface using angle dependent X-ray photoelectron spectroscopy. The observation of the S 2p line, in the case of MPTMS, and the C 1s line for both MPTMS and PTES confirms the adsorption of the molecules. For a dose of 122 Langmuirs of MPTMS w

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We examine how the gender of a sibling affects labor market outcomes and family formation. Identification is complicated by parental preferences: if parents prefer certain sex compositions over others, children’ s gender affects not only the outcomes of other children but also the existence of potential additional children. We employ two empirical strategies that both address this problem. First,

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PalCom is a middleware toolkit for pervasive computing and internet-of-things. We discuss how PalCom supports exploration and live programming through three phases: exploring services, assembling them into applications, and exposing them as new services. We give an example of this workflow through the construction of a simple photo booth application.

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This paper is an empirical examination of the determinants of aggregate health care expenditure. The paper presents a systematic analysis of relationships across 19 OECD countries, showing the effects of aggregate income, institutional and socio-demographic factors on health care expenditure. The results indicate that institutional factors of the health systems, in addition to per capita Gross Dom

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Tobacco smoking is a major health and economic concern and is also known to have a significant negative effect on surgical outcomes. The benefits of a smoking cessation intervention prior to elective orthopaedic surgery have been evaluated previously. Our aim was to assess whether a smoking cessation program, initiated during the acute hospitalization period and carried out for six weeks, could re

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Importance: Whether certain weather conditions modulate the onset of myocardial infarction (MI) is of great interest to clinicians because it could be used to prevent MIs as well as guide allocation of health care resources. Objective: To determine if weather is associated with day-to-day incidence of MI. Design, Setting, and Participants: In this prospective, population-based and nationwide setti

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PURPOSE OF REVIEW: The clinical and inflammatory heterogeneity in asthma constitutes a major challenge for improved treatment. This review describes the nature of the inflammatory complexity and how it can be decoded to yield improved disease understanding and personalized treatment. The focus is on the difficult task of revealing the immunological complexity as it occurs inside diseased patient t

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Background Norwood surgery provides a palliative surgical option for hypoplastic left heart syndrome and has been available in Sweden since 1993. The practice of prenatal ultrasound screening was gradually implemented in the same era, resulting in an increased prenatal detection rate. Our primary aims were to study changes in the incidence of live births, prenatal detection rate, and the terminati

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BACKGROUND AND PURPOSE: Previous studies of familial risks have often combined ischemic and hemorrhagic stroke even though it seems unlikely that these 2 very different pathological conditions are under the same genetic influence. This study is the first to investigate the concordant (same subtype) and disconcordant (different subtype) association between ischemic and hemorrhagic stroke.METHODS: D

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Background Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with those of adults. Methods We pooled 2416 popu

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Bladder cancers are biologically and clinically heterogeneous. Recent large-scale transcriptomic profiling studies focusing on life-threatening muscle-invasive cases have demonstrated a small number of molecularly distinct clusters that largely explain their heterogeneity. Similar to breast cancer, these clusters reflect intrinsic urothelial cell-type differentiation programs, including those with

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For help in explaining our theoretical understanding of nature, Pauli once suggested to Bohr a gradual lessening of the ‘detachment of the observer’, a notion of Bohr based on his concept of complementarity. Pauli expected further steps in this direction. We suggest further such steps - in line with an epistemological development towards revelation of presuppositions rather than asking for fundame

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Environmental assessment of buildings has become an increasing research field and the methodology of LCA is increasingly used. In case studies, the phase after demolition is mostly either excluded or handled in a rather limited way. However, in the design phase, the aspects of future recycling needs to be regarded and by that the phases after demolition. Inclusion of these aspects in the assessmen

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Pathogenic microbes have evolved sophisticated molecular strategies to subvert host defenses. Here we show that virulent bacteria interfere directly with Toll-like receptor (TLR) function by secreting inhibitory homologs of the Toll/interleukin-1 receptor (TIR) domain. Genes encoding TIR domain containing–proteins (Tcps) were identified in Escherichia coli CFT073 (TcpC) and Brucella melitensis (Tc