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OBJECTIVE: We previously performed a population-based mass screening of coeliac disease in children aged 12 years in two birth cohorts resulting in 296 seropositive children, of whom 242 were diagnosed with coeliac disease after duodenal biopsies. In this follow-up study, we wanted to identify new cases in the screening population that tested negative-either converting from potential coeliac disea

The PRDM family of methyltransferases has been implicated in cellular proliferation and differentiation and is deregulated in human diseases, most notably in cancer. PRDMs are related to the SET domain family of methyltransferases; however, from the 19 PRDMs only a few PRDMs with defined enzymatic activities are known. PRDM15 is an uncharacterized transcriptional regulator, with significant struct

TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the hig

In 2021 the Swedish media started investigating Romani trials, a supposed ‘parallel legal system’ that is practiced by some Romanies. Before 2021 the reportage on the phenomena is minimal. In general, academic research on Romani legal culture in Sweden is absent, similar goes for Romani representation in Swedish media. This thesis explores how Romani legal culture is represented in the Swedish med

In 2004, Denmark implemented a new law which allows the police to issue so-called “Stop & Search zones”, as a measure to defeat mainly violent crimes. In Sweden, the implementation of such zones is a current frequently occurring matter in the political debate and parliamentary motions, in the context of defeating gang crime. One common argument in favor of implementation is “It works in Denmar

Background: To explore the patients' experiences during the three decades following repair of a nerve injury in the forearm and its consequences for daily life. Strategies that were used to facilitate adaptation were also investigated. Methods: Fifteen participants with a complete median and/or ulnar nerve injury repaired in the ages from 13-20 years were interviewed using a semi-structured interv

Popular Abstract in Swedish I hjärnan finns många olika typer av nervceller. De använder sig av olika signalsubstanser, kallade neurotransmittorer, för att kommunicera med andra nervceller. En viss typ av nervceller använder neurotransmittorn dopamin. Dopaminceller finns på många ställen i hjärnan men de flesta ligger i mellanhjärnan i ett par olika cellgrupper som var och en skickar signaler tillParkinsons disease (PD) is a neurodegenerative disorder where dopaminergic neurons of the substantia nigra (SNc) in the mesencephalon are progressively eliminated. The ensuing loss of dopaminergic innervation of the basal ganglia manifests itself as severe motor deficits in PD patients. Clinical trials have shown that cell replacement therapy, where dopaminergic neuroblasts derived from fetal vent

On 24 March 2004, the European Commission found Microsoft Corporation guilty of violating Article 82 of the EC Treaty. Consolidated version of the Treaty establishing the European Community, OJ C 325, 24.12.2002. The Commission established two separate violations of the provision. However, the relevant abuse in relation to this thesis was the finding of illegal tying by technical integration of Wi

Connecting science to political agenda-setting is essential for a sustainable transition and acceptable politics. This task is complicated by phenomena like post-truth, for which facts are a non-issue. However, post-truth is not the only issue. The practice of political spin, in which the significance of facts is reconstructed according to specific interests poses another threat to scientific cred

This paper empirically surveys the actual links between financial liberalization and economic growth by drawing lessons from both developed and emerging economies over 26 years. The macroeconomic indicators for economic growth are GDP per capita growth, growth volatility, and real lending interest rate. Previous researches hold differing views about whether the impact of liberalization reform on m

Background The widespread antibiotic resistance is an imminent problem in today’s world. As the number of antibiotic resistance cases increase, it is inevitable to discover alternate treatment options. Probiotics could be one of the potentially important avenues which could be exploited to treat antibiotic resistance and other infections. The holistic approach of probiotics in exerting their benef

Background: In todayʼs fast moving world, the communication of science and technology is playing an increasingly important role for the relation between science and the public. Both journalists and researchers have their own agenda when communicating as public interest, corporate science and the competition for funding increases. At the same time, the conditions on which stories about science can

The male genital tract is rich in proteases, delivered by the male accessory sex glands, that are delicately balanced in their action by serpins, non-serpin class protease inhibitors and other regulatory mechanisms. Still, the biological function of the serpins and their target enzymes in the male genital tract and possible involvement in the regulation of normal reproductive function mainly remai

Objective: Stroke and carotid atherosclerosis are associated with dementia. Carotid endarterectomy (CEA) reduces stroke risk, although its effect on later dementia is uncertain. Participants in the Asymptomatic Carotid Surgery Trial (ACST-1), randomly allocated to immediate vs. deferral of CEA (i.e., no intervention unless or until triggered by ipsilateral transient ischaemic attack or stroke), we

Remote patient monitoring should reduce mortality rates, improve care, and reduce costs. We present an overview of the available technologies for the remote monitoring of chronic obstructive pulmonary disease (COPD) patients, together with the most important medical information regarding COPD in a language that is adapted for engineers. Our aim is to bridge the gap between the technical and medica