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Sick leave due to mental health problems is increasing, and there is evidence that it is associated with the individual’s self-perceived organisational and social work environment. The aim of this study was to compare occupational therapists’ self-perceived organisational and social work environments in different job sectors. The goal is to identify the sectors with the most unfavourable work envi
Objective: To assess the relationship between acetabular dysplasia (AD) and the risk of incident and end-stage radiographic hip osteoarthritis (RHOA) over 2,5,8 and 10 years. Design: Individuals (n = 1002) aged between 45 and 65 from the prospective Cohort Hip and Cohort Knee (CHECK) were studied. Anteroposterior pelvic radiographs were obtained at baseline and 2,5,8, and 10-years follow-up. False
Importance: Disulfiram has demonstrated broad antitumoral effect in several preclinical studies. One of the proposed indications is for the treatment of glioblastoma. Objective: To evaluate the efficacy and safety of disulfiram and copper as add-on to alkylating chemotherapy in patients with recurrent glioblastoma. Design, Setting, and Participants: This was a multicenter, open-label, randomized p
Typical patterns of the Late Pleistocene loess–paleosol units are preserved in the Novo Orahovo brickyard, Northern Serbia. Presented preliminary luminescence chronology supports the chronostratigraphic interpretations of global isotopic marine climate reconstructions. Magnetic susceptibility and sedimentological evidence exhibit general similarities with the marine oxygen-isotope stratigraphy. Th
Introduction: Glycolytic activity and hypoxia are associated with poor prognosis and radiation resistance. Including both the tumor uptake of 2-deoxy-2-[18 F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer copper(II)diacetyl-bis(N4)-methylsemithio-carbazone (Cu-ATSM) in targeted therapy planning may therefore lead to improved tumor control. In this study we analyzed the overlap between s
Purpose: Although past studies have found well-constrained soil carbon (C)/nutrient ratios, the effects of increased nitrogen (N) and water inputs on these ratios across soil depths have rarely been assessed in semi-arid grasslands. Methods: In this study, we evaluated the contents of total C, N, phosphorus (P), sulfur (S), and their stoichiometric ratios in a 0–80 cm soil profile following 13 yea
Introduction: Head-to-head evaluation of valoctocogene roxaparvovec, the first gene therapy approved for haemophilia A, with emicizumab is not available. Therefore, phase 3 trial data were indirectly compared. Aim: To compare bleeding rates in trials evaluating 6 × 1013 vg/kg valoctocogene roxaparvovec (GENEr8-1; NCT03370913), 1.5 mg/kg emicizumab dosed every week (HAVEN 3; NCT02847637), and FVIII
BACKGROUND: Patients with critical COVID-19 have a high risk of thromboembolism, but intensified thromboprophylaxis has not been proven beneficial. The activity of low-molecular-weight heparins can be monitored by measuring anti-Factor Xa. We aimed to study the association between anti-Factor Xa values and death, thromboembolism, and bleeding in patients with critical COVID-19.METHOD: This retrosp
Summary: Kidney function decreases with age; however, the long-term influence on bone density (BMD) in older women already at risk of osteoporosis is unknown. We followed kidney function and bone loss for 10 years. Declining kidney function was adversely associated with bone loss and mineral homeostasis in old women, though it attenuated with advanced aging. Introduction: Existing studies do not f
The structural properties, and the intracrystalline swelling of Na+-, and Ca2+-montmorillonite (Na-, and Ca-mmt) have been investigated as an effect of decreasing the relative permittivity of the solvent, i.e. from water to ethanol (EtOH), utilizing the experimental techniques; small angle X-ray scattering (SAXS) and osmotic pressure measurements. The experimental data were compared with the conti
BACKGROUND AND PURPOSE: An increasing number of radiotherapy centres is now aiming for clinical implementation of intensity modulated radiotherapy (IMRT), but--in contrast to conventional treatment--no national or international guidelines for commissioning of the treatment planning system (TPS) and acceptance tests of treatment equipment have yet been developed. This paper bundles the experience o
Objective: To study whether locally administered recombinant inactivated human coagulation factor VIIa (FFR-rFVIIa) would reduce the thrombus formation and improve patency in an experimental venous thrombosis model without inducing systematic changes in the coagulation. Design: Experimental double-dummy randomised study. Materials: In 20 healthy New Zealand White rabbits both juguIar veins were ex
The aim was to investigate whether a truncated recombinant Tissue Factor Pathway Inhibitor (TFPI1-161) which lacked the third Kunitz-type domain and the basic c-terminal region, had an antithrombotic effect comparable to LMWH in a randomised double-dummy study. The experimental thrombosis was induced in jugular veins, in a total of 40 rabbits by a combination of destruction of the endothelium and
Textile handicrafts are often seen as an important tool for women to handle times of crisis and societal change. This chapter explores and discusses the Swedish humanitarian organisation Individuell Människohjälp (Swedish Development Partner), IM, and its strategies of developing local traditions of textile handicraft work as help to self-help in the small mountain village of Vlasti in Northern Gr
Objective: To estimate the 12-year risk of radiographic and/or symptomatic knee osteoarthritis following different MRI-confirmed soft-tissue knee injuries. Design: Prospective cohort study including 814 (70 %) of 1129 consecutive patients after acute knee trauma with hemarthrosis in a single hospital. Injuries were classified by sub-acute knee MRI. Follow-up comprised bilateral knee radiography a
This study provides a systematic overview of Natural Language Processing (NLP)-based frameworks for Cyber Threat Intelligence (CTI) and the early prediction of cyberattacks in Industry 4.0. As digital transformation accelerates through the integration of IoT, SCADA, and cyber-physical systems, manufacturing environments face an expanding and complex cyber threat landscape. Following the PRISMA 202
This article analyses the industrial enterprise of the Dutch-born brothers Abraham and Jakob Momma-Reenstierna and their investments in Sápmi and the upper parts of the Torne River Valley, northern Sweden, during the second half of the seventeenth century. The aim is to explore the driving forces behind the industrial projects of the two brothers in a larger global and colonial context. With inspi
Using data on 119 low- and lower-middle-income countries from 2002 to 2020, we fit fixed-effects (FE) models to evaluate the impacts of three types of official development assistance (ODA) on access to three types of sexual and reproductive health (SRH) services: access to skilled birth attendance, access to modern contraceptives and coverage of antiretroviral therapies against HIV/AIDS. The resul
Rural populations in Europe face health inequalities due to a multitude of factors, including the higher prevalence of multi-morbidity, inadequate access to primary and secondary health care services, and widespread health workforce shortages. Although some challenges are also present in other contexts, the multitude and interconnectedness of these factors induce significant health inequalities. R
An ‘implementation gap’ between law and practice has long been noticed by scholars and practitioners of children’s rights. This chapter goes beyond critiquing such a gap by unpacking and deconstructing the very notion of ‘implementation.’ It empirically studies how India’s national child helpline, and thereby children’s protection rights, are implemented in the state of Madhya Pradesh in North Ind
