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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 193160 hits

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Environmental and forest conservation have long been perceived as a constraint to economic growth and development. With a growing understanding of the benefits from ecosystem services for people, and benefits for conservation when managed by local people, synergies between conservation and development have become more prominent. This research paper analyses this link by looking at ecotourism as a

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Sexualbrottsoffer vågar inte anmäla det dem utsatts för, inte av rädsla för förövaren utan av rädsla för själva processen. Juridiken ses som en egen suverän organisation, frånskild verklighetens problem och individer. När brottsoffret väl anmäler och går in i denna rättsliga bubbla, är det inte offrets verkliga behov och rättigheter som är styrande för processen. Istället används sexualbrottsofferVictims of sexual crime do not dare to report the assault they were subjected to, not for fear of the perpetrator but for fear of the criminal process itself. The legal system is seen as a sovereign organization, out of touch with the reality, and out of touch with the problems and individuals of the society. If, however, the victim reports the crime and through that enters this legal bubble, it i

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This study aims to investigate the relationship between memory control ability and a range of borderline personality symptoms in nonclinical participants. It also aims to explore whether emotion regulation skills are a mediator of this relationship. 61 participants completed an adapted, online think/no think experiment using scene-object picture pairs to investigate their memory control. They also

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Damage to DNA can cause death to an individual cell and serious harm to the host organism. Photosensitized reactions are one cause of DNA damage. It can lead to destructive chemical reactions targeted to a base of the DNA as well as a breakage along one or both of the DNA strands. Due to this, quantifying and understanding photosensitized driven DNA damage is an important topic of research. From

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Yes-associated protein (YAP1) is frequently reported to function as an oncogene in many types of cancer, but in breast cancer results remain controversial. We set out to clarify the role of YAP1 in breast cancer by examining gene and protein expression in subgroups of patient material and by downregulating YAP1 in vitro and studying its role in response to the widely used anti-estrogen tamoxifen.

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Background: The identification of novel genes by high-throughput studies of complex diseases is complicated by the large number of potential genes. However, since disease-associated genes tend to interact, one solution is to arrange them in modules based on co-expression data and known gene interactions. The hypothesis of this study was that such a module could be a) found and validated in allergi

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Background. In metastatic colorectal cancer, mutation testing for KRAS exon 2 is widely implemented to select patients with wild-type tumors for treatment with the monocloncal anti-EGFR antibodies cetuximab and panitumumab. The added predictive value of additional biomarkers in the RAS-RAF-MAPK and PI3K-AKT-mTOR pathways in colorectal cancer is uncertain, which led us to systematically review the

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In the recent years, large progresses in laser imaging techniques have allowed to extract spatially resolved 2D and 3D quantitative spray information even in optically dense situations. The main breakthrough of these techniques is the possibility of suppressing unwanted effects from multiple light scattering using Structured Illumination. Thanks to this new feature, effects due to light extinction

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The objective of this study was to evaluate the potential of nanofiltration (NF) and ozonation for indirect potable reuse in terms of pharmaceutical residuals. To simultaneously obtain a reasonable retentate volume for further treatment, the tests were performed at a high volume reduction factor (VRF) of 60. The feed to the pilot plant was the effluent from a BNR plant with a final process step of

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The southern Peruvian coastal desert around Palpa, southern Peru (14.5 degrees S) is currently characterized by hyper-arid conditions. However, the presence of two species of molluscs (Scutalus, Pupoides) and desert-loess deposits indicates the past development of semi-desert and grassland ecosystems caused by a displacement of the eastern desert margin due to hydrological changes. Radiocarbon dat

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Context: Scope management is a core part of software release management and often a key factor in releasing successful software products to the market. In a market-driven case, when only a few requirements are known a priori, the risk of overscoping may increase. Objective: This paper reports on findings from a case study aimed at understanding overscoping in large-scale, market-driven software dev

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AimReal-life studies are needed to confirm the clinical relevance of findings from randomised controlled trials (RCTs). This study aimed to assess the effectiveness and tolerability of vildagliptin add-on vs. other oral antihyperglycaemic drugs (OADs) added to OAD monotherapy in a real-life setting, and to explore the advantages and limitations of large-scale pragmatic' trials. MethodsEDGE was a p

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Background: The purpose of the study was to evaluate time trends and effects of co-existing autism spectrum disorders (ASD) on outcome in an ongoing long-term follow-up study of anorexia nervosa (AN). Methods: The Morgan-Russell Outcome Assessment Schedule (MROAS) was used at 6-, 10- and 18-year follow-up of a representative sample of 51 individuals with teenage-onset AN and a matched group of 51

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In recent years the populations of the lesser spotted woodpecker (Dendrocopos minor) has been declining in Sweden. Many other species, like for example the marsh tit (Poecile palustris), depend on woodland structures that the lesser spotted woodpecker creates such as nesting holes. I did a comparison study between data from The Lesser Spotted Woodpecker Project made in 1980’s and my own recently c

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The focus of this bachelor’s essay is to investigate non-lexical interjections. In this study, imitative interjection proves to be an appropriate term for interjections such as mm-hmm and wow, with non-lexical properties distinguishing them from hey and yes. This essay aims to explore if this specific group can be extracted from a corpus, and further, if it is possible to detect any similarities a