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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 113607 hits

Sunscreen use and malignant melanoma

In a new population-based, matched, case-control study from southern Sweden of 571 patients with a first diagnosis of cutaneous malignant melanoma, between 1995 and 1997, and 913 healthy controls aged 16 to 80 years, the association between sunscreen use and malignant melanoma was evaluated. The median sun protection factor (SPF) used by both cases and controls was 6, range 2 to 25. Sunscreen user

Lower bone turnover and relative bone deficits in men with metabolic syndrome : a matter of insulin sensitivity? The European Male Ageing Study

Summary: We examined cross-sectional associations of metabolic syndrome and its components with male bone turnover, density and structure. Greater bone mass in men with metabolic syndrome was related to their greater body mass, whereas hyperglycaemia, hypertriglyceridaemia or impaired insulin sensitivity were associated with lower bone turnover and relative bone mass deficits. Introduction: Metabo

Improved Greedy Nonrandomness Detectors for Stream Ciphers

We consider the problem of designing distinguishers and nonrandomness detectors for stream ciphers using the maximum degree monomial test. We construct an improved algorithm to determine the subset of key and IV-bits used in the test. The algorithm is generic, and can be applied to any stream cipher. In addition to this, the algorithm is highly tweakable, and can be adapted depending on the desire

Experimental investigations of potassium chemistry in premixed flames

Quantitative potassium species concentrations have been measured in alkali-seeded premixed methane-air flames of different stoichiometry. Potassium chloride (KCl) and hydroxide (KOH) were measured by broadband UV absorption spectroscopy and laser-induced photofragmentation fluorescence, while atomic potassium was measured using tuneable diode-laser spectroscopy. In addition, laser Rayleigh scatter

Site-selective 13C labeling of histidine and tryptophan using ribose

Experimental studies on protein dynamics at atomic resolution by NMR-spectroscopy in solution require isolated 1H-X spin pairs. This is the default scenario in standard 1H-15N backbone experiments. Side chain dynamic experiments, which allow to study specific local processes like proton-transfer, or tautomerization, require isolated 1H-13C sites which must be produced by site-selective 13C labelin

HFMADM method based on nondimensionalization and its application in the evaluation of inclusive growth

Inclusive growth, which encompasses different aspects of life, is a growth pattern that allows all people to participate in and contribute to growth process. In this paper, a novel hesitant fuzzy multiple attribute decision making (HFMADM) approach based on the nondimensionalization of decision making attributes is presented and then applied to the evaluation of inclusive growth in China. Firstly,

Regeneration of long-distance peripheral nerve defects after delayed reconstruction in healthy and diabetic rats is supported by immunomodulatory chitosan nerve guides

Background: Delayed reconstruction of transection or laceration injuries of peripheral nerves is inflicted by a reduced regeneration capacity. Diabetic conditions, more frequently encountered in clinical practice, are known to further impair regeneration in peripheral nerves. Chitosan nerve guides (CNGs) have recently been introduced as a new generation of medical devices for immediate peripheral

Patients with poor responsiveness to thienopyridine treatment or with diabetes have lower levels of circulating active metabolite, but their platelets respond normally to active metabolite added ex vivo.

OBJECTIVES: We evaluated the prevalence and mechanism of poor responsiveness to clopidogrel and prasugrel in coronary artery disease patients with and without diabetes. BACKGROUND: Low platelet inhibition by clopidogrel is associated with ischemic clinical events. A higher 600-mg loading dose (LD) has been advocated to increase responsiveness to clopidogrel. METHODS: In this study, 110 aspirin-tre

Guidelines for reporting and using prediction tools for genetic variation analysis

Computational prediction methods are widely used for analysis of human genome sequence variants and their effects on gene/protein function, splice site aberration, pathogenicity, and disease risk. New methods are frequently developed. We believe that guidelines are essential for those writing articles about new prediction methods, as well as for those applying these tools in their research, so tha

The Role of Judicial Associations in Resisting Rule of Law Backsliding : Hidden Pathways of Protecting Judicial Independence Amidst Rule of Law Decay

Both Hungary and Poland have been in the spotlight regarding their democratic backsliding, with Executives exerting control over supposedly independent pillars of democracy, such as courts or the media. While the concerns about these countries also voiced by leaders of European institutions were similar, the resistance against the systematic erosion of judicial independence comes in different form

A New Sieving-style Information-set Decoding Algorithm

The problem of decoding random codes is a fundamental problem for code-based cryptography, including recent code-based candidates in the NIST post-quantum standardization process. In this paper, we present a novel Sieving-style Information-set Decoding algorithm, addressing the task of solving the syndrome decoding problem. Our approach involves maintaining a list of weight-2p solution vectors to

Patients Aged 80 or More With Distal Radius Fractures Have a Lower One-Year Mortality Rate Than Age- and Gender-Matched Controls : A Register-Based Study

Introduction: With a rapidly ageing population, the number of distal radius fractures (DRFs) in the elderly will increase dramatically. The aim of this retrospective register study was to examine the 1- and 5-year mortality in DRF patients aged 80 years or more and correlate the overall survival to factors not related to the fracture itself. Material and Methods: Patients aged ≥80 diagnosed with D

Religious and De-extremization Regulations and Their Dissemination in the XUAR

The current situation of Uyghurs in the Xinjiang Uyghur Autonomous Region (XUAR) is considered by many as one of the most pressing human rights violations of the last few decades. The Uyghurs, being an ethnic minority in China, are voiceless under the current political leadership, which suppresses anything deviating from the official course set up by the Party leaders in Beijing. The legal guarant