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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 114350 hits

The Quebec classification and a new Swedish classification for whiplash-associated disorders in relation to life satisfaction in patients at high risk of chronic functional impairment and disability

Unlike the Quebec classification system, which is based primarily on pathoanatomy, a new Swedish classification system is based on the site of functional impairment and disability. A prospective study was performed on 85 patients with whiplash-associated disorders grade II according to the Quebec classification. The patients were examined 3-36 months following trauma. A team of professionals with

Exploiting Temperature Dependency in the Detection of NQR Signals

Nuclear quadrupole resonance (NQR) offers an unequivocal method of detecting and identifying land mines. Unfortunately, the practical use of NQR is restricted by the low signal-to-noise ratio (SNR), and the means to improve the SNR are vital to enable a rapid, reliable, and convenient system. In this paper, an approximate maximum-likelihood detector (AML) is developed, exploiting the temperature d

ECG-based detection of body position changes in ischemia monitoring

The purpose of this gaper is to analyze and detect changes in body position (BPC) during electrocardiogram (ECG) recording. These changes are often manifested as shifts in the, electrical axis and may be misclassified as ischemic changes during. ambulatory monitoring. We investigate two ECG signal processing methods for detecting BPCs. Different schemes for feature extraction are used (spatial and

In vitro toxicity of biomaterials determined with cell density, total protein, cell cycle distribution and adenine nucleotides

Inhibition of cell growth is the most commonly used endpoint for in vitro toxicity of biomaterials. The use of several different endpoints might however generate more information concerning the nature of the toxicity. Thus, we examined the toxicity of two biomaterials, Polyvinylchloride (PVC) and Polyoximethene (POM), with different selected endpoints. The influence of cell growth on these endpoin

WE-14, a chromogranin A - Derived neuropeptide

The neuropeptide WE-14 is derived from the posttranslational processing of chromogranin A (CgA). While CgA is expressed in a preponderance of neuroendocrine cells, WE-14 is generated in a distinct subpopulation of CgA-immunopositive cells, most notably in the adrenal, pituitary, and parathyroid glands. Physiological and pharmacological studies have demonstrated that CgA is cleaved to generate WE-1

Consumers choice of organic versus conventional fruit and vegetables - The role of the grocery store

This paper presents findings from two explorative studies. One is a consumer study based on interviews with consumers in real store settings and one is a study based on interviews with fruit and vegetable managers of stores affiliated with a major food retail chain in Sweden. The aim of both studies was to explore the role of the grocery store for the consumers' choice of organic versus convention

Recursive parametrization and invariant phases of unitary matrices

We present further properties of a previously proposed recursive scheme for parametrization of n-by-n unitary matrices. We show that the factors in the recursive formula may be introduced in any desired order. The method is used to study the invariant phases of unitary matrices. The case of four-by-four unitary matrices is investigated in detail. We also address the question of how to construct sy

A numerical study of two-dimensional compaction, flow and dispersion in a chromatographic column

Mathematical and numerical modeling of the complex interplay between compaction, flow, and hydrodynamic dispersion in a chromatographic column under steady stale conditions has been examined. The mathematical model was based on pure elastic analysis and Darcy flow. A two-dimensional control volume approach was applied to solve the coupled nonlinear equations describing the flow and compaction. The

Automatic memory management for flexible real-time systems

Popular Abstract in Swedish I flexibla realtidssystem leder begränsningarna i processorkraft och minne till resurshanteringsproblem som måste hanteras väl för att både maximera systemets prestanda och undvika överlast. Problemet att tilldela processortid -- schemaläggning -- är väl undersökt och dynamisk schemaläggning är allmänt accepterad i industrin. För att göra säkra högnivåspråk, som Java, pIn a flexible real-time system, the constraints in available CPU time and memory lead to resource management problems, which must be handled carefully in order to maximize quality of service while avoiding overload. Managing CPU time -- scheduling -- is well studied and dynamic scheduling is widely accepted in the real-time industry. In order to make safe high-level languages, like Java, practical

Quantum refinement in real and reciprocal space using the Phenix and ORCA software

X-ray and neutron crystallography, as well as cryogenic electron microscopy (cryo-EM), are the most common methods to obtain atomic structures of biological macromolecules. A feature they all have in common is that, at typical resolutions, the experimental data need to be supplemented by empirical restraints, ensuring that the final structure is chemically reasonable. The restraints are accurate f

Cutting through the noise : A narrative review of Alzheimer's disease plasma biomarkers for routine clinical use

As novel, anti-amyloid therapies have become more widely available, access to timely and accurate diagnosis has become integral to ensuring optimal treatment of patients with early-stage Alzheimer's disease (AD). Plasma biomarkers are a promising tool for identifying AD pathology; however, several technical and clinical factors need to be considered prior to their implementation in routine clinica

Contributions of injury deaths to changes in life expectancy and disparity : A comparative analysis of G7 countries over two decades

BACKGROUND: Despite the high level of economic development in the Group of Seven (G7) countries, injury deaths remain a public health concern in these countries. This paper examines the contribution of injury deaths to changes in life expectancy (LE) and life disparity (LD) in the G7 countries.METHODS: We used annual data from the WHO mortality database to compute LE and LD during 2001-03 and 2017

Independent and Joint Effects of the MAPT and SNCA Genes in Parkinson Disease

Objective: We studied the independent and joint effects of the genes encoding alpha-synuclein (SNCA) and microtubule-associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta-analysis of individual data from case-control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium. Methods: Participants of Caucasian ancestry were genotyped for

Impact of comorbidity on family genetic risk profiles for psychiatric and substance use disorders : A descriptive analysis

Background - Comorbidity between psychiatric disorders is extensive but, from a genetic perspective, still poorly understood. Modern molecular genetic approaches to this problem are limited by a reliance on case-control designs. Methods - In 5 828 760 individuals born in Sweden from 1932-1995 with a mean (s.d.) age at follow-up of 54.4 (18.1), we examined family genetic risk score (FGRS) profiles

Mediterranean, DASH, and MIND Dietary Patterns and Cognitive Function : The 2-Year Longitudinal Changes in an Older Spanish Cohort

Background and Aims: Plant-forward dietary patterns have been associated with cardiometabolic health benefits, which, in turn, have been related to cognitive performance with inconsistent findings. The objective of this study was to examine the relationship between baseline adherence to three a priori dietary patterns (Mediterranean, DASH, and MIND diets) with 2-year changes in cognitive performan

Technical and conceptual considerations for using animated stimuli in studies of animal behavior

Rapid technical advances in the field of computer animation (CA) and virtual reality (VR) have opened new avenues in animal behavior research. Animated stimuli are powerful tools as they offer standardization, repeatability, and complete control over the stimulus presented, thereby "reducing" and "replacing" the animals used, and "refining" the experimental design in line with the 3Rs. However, ap

Prevalence of mental health problems, associated factors, and health-related quality of life in children with long-gap esophageal atresia in Sweden

Background: Children with long-gap esophageal atresia (LGEA) face a high risk of digestive and respiratory morbidity, but their mental health outcomes have not been investigated. We aimed to identify the prevalence of mental health problems in children with LGEA, associated factors and health-related quality of life (HRQOL). Methods: Twenty-six children with LGEA aged 3–17 were recruited nationwid