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This study provides a systematic overview of Natural Language Processing (NLP)-based frameworks for Cyber Threat Intelligence (CTI) and the early prediction of cyberattacks in Industry 4.0. As digital transformation accelerates through the integration of IoT, SCADA, and cyber-physical systems, manufacturing environments face an expanding and complex cyber threat landscape. Following the PRISMA 202
This article analyses the industrial enterprise of the Dutch-born brothers Abraham and Jakob Momma-Reenstierna and their investments in Sápmi and the upper parts of the Torne River Valley, northern Sweden, during the second half of the seventeenth century. The aim is to explore the driving forces behind the industrial projects of the two brothers in a larger global and colonial context. With inspi
Using data on 119 low- and lower-middle-income countries from 2002 to 2020, we fit fixed-effects (FE) models to evaluate the impacts of three types of official development assistance (ODA) on access to three types of sexual and reproductive health (SRH) services: access to skilled birth attendance, access to modern contraceptives and coverage of antiretroviral therapies against HIV/AIDS. The resul
Rural populations in Europe face health inequalities due to a multitude of factors, including the higher prevalence of multi-morbidity, inadequate access to primary and secondary health care services, and widespread health workforce shortages. Although some challenges are also present in other contexts, the multitude and interconnectedness of these factors induce significant health inequalities. R
Selective TDP-43 overexpression in oxytocin neurons in the paraventricular nucleus of the hypothalamus causes a decrease in oxytocin-immunopositive cells compared to uninjected mice. AAV-mediated TDP-43 overexpression in oxytocin neurons does not appear to be a major driver of behavioural and metabolic phenotypes in mice.
Background: Wrist osteoarthritis can cause persistent pain, reduced joint mobility, and difficulty performing daily activities, negatively impacting quality of life. Although patient education and exercise therapy are recommended as first-line treatments for osteoarthritis in other joints, evidence supporting these strategies for wrist osteoarthritis remains limited. This randomized controlled tri
BackgroundUmbilical cord arterial pH (UApH) is the most objective measurement of the metabolic condition of the infant at birth. However, studies have identified changes in UApH with advancing gestational age, as there is limited data examining UApH changes with different modes of birth. The objective was to establish reference values for UApH according to mode of birth and to investigate the infl
The Colombian Peace Agreement signed in 2016 was saluted internationally by scholars, policy makers and practitioners for encompassing the concept of territorial peace as a means of ensuring local participation in the strengthening of state institutions. Based on engaged research conducted in the Department of Cauca and Bogotá between 2017 and 2020, we critically analyse territorial peace, explori
This study aimed to evaluate the clinical acceptability of artificial intelligence (AI)-based organ segmentations on pretreatment CT images of prostate cancer patients using manual organ delineations as a reference. Paired AI-based segmentations and manual delineations of the prostate, urinary bladder, and rectum were evaluated by three observers, according to a 4-grade Likert-scale, based on qual
Background: Less adults with cerebral palsy (CP) lives independently, compared to adults without disabilities. Access to personal assistance may help overcome barriers to independent living. Also, little is known about hand function in adults with CP, and the role of hand function in achieving independent living remains unexplored. Objective: To explore the associations between housing and persona
Intense agricultural activity in recent years has resulted in a greater use of pesticides in order to improve productivity. However, these pesticides may contain some pollutant component in their composition. Once present in the environment and/or in excess, they can cause damage to the local flora and fauna. The aim of this study was to evaluate the interference of pesticides in the reproductive
An ‘implementation gap’ between law and practice has long been noticed by scholars and practitioners of children’s rights. This chapter goes beyond critiquing such a gap by unpacking and deconstructing the very notion of ‘implementation.’ It empirically studies how India’s national child helpline, and thereby children’s protection rights, are implemented in the state of Madhya Pradesh in North Ind
Numerous neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis share a neuropathological hallmark: aberrant protein aggregation in the CNS. Microglia, the brain's innate immune cells, also play a pivotal role in the pathogenesis of these disorders. Multiple studies indicate that these pathological aggregates can propagate throughout the brain
Background: Alcohol use disorder (AUD) is associated with an enormous burden of disease and cost to society. The dopamine deficiency hypothesis posits that negative reinforcement generated by a low brain dopamine state drives ethanol intake. Here, we evaluated the efficacy and safety of combined administration of two dopamine-enhancing drugs, varenicline (a partial nicotinic acetylcholine receptor
Background and Hypothesis: To clarify, in a large, representative, longitudinal sample, the rate and predictors of diagnostic conversion from Bipolar Disorder (BD) to Schizophrenia (SZ) and from SZ→BD. Design: From individuals born in Sweden 1950–1995 and living there in 1970 or later, we identified at least one initial diagnoses of SZ (n = 8449) and BD (n = 8438) followed for a minimum of 10 and
BACKGROUND AND PURPOSE: Data on distal radius fractures (DRFs) with concomitant metaphyseal distal ulna fractures is limited. We aimed to determine whether a combined DRF and distal ulna fracture (DRUF) predicts a worse patient-reported outcome, measured by the Disabilities of the Arm, Shoulder, and Hand (DASH) score, 1 year after injury.METHODS: This prospective registry-based cohort study includ
Two major debates frame Arctic prehistory: the emergence of specialized maritime economies that support sedentism and growing socio-political complexity, and the role of these economies in the transition from Paleo-Inuit to Neo-Inuit traditions. This shift, originating in the Bering Strait, led to Thule Inuit dispersal across the Arctic, impacting Indigenous communities today. However, understandi
A new 130 to 140 Ma mafic dyke swarm, is identified in western South Africa. It consists of the previously undated Cederberg dyke swarm (CDS), for which we report U-Pb ID-TIMS baddeleyite ages of 131.4 ± 4.5 Ma (Knersvlake subswarm) and 133.0 ± 1.5 Ma (Doring-Tanqua subswarm).40Ar/39Ar dates on these two samples and two additional dates of the Doring – Tanqua subswarm cluster between 128.5 ± 1.4 M
We present a new instrument, "Boreas", a cryogen-free methane (CH4) preconcentration system coupled to a dual-laser spectrometer for making simultaneous measurements of δ13C(CH4) and δ2H(CH4) in ambient air. Excluding isotope ratio scale uncertainty, we estimate a typical standard measurement uncertainty for an ambient air sample of 0.07‰ for δ13C(CH4) and 0.9‰ for δ2H(CH4), which are the lowest r
Heavy metal (HM) pollution remains a pressing global concern, affecting soil regarding food safety, and negatively influencing the UN Sustainable Development Goals (SDGs). We investigated the efficacy of untreated cypress biochar (UCB) and Ca-modified cypress biochar (MCB) in mitigating HM contamination and enhancing growth across native and contaminated soils (40 mg/kg) in carrot pot experiments.
