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Mutated Nucleophosmin 1 (NPM1) is the most common genetic alteration in acute myeloid leukemia (AML), found in approximately 30% of cases. Although mutations in this gene are considered favorable according to current risk stratification guidelines, a large fraction of patients will suffer from relapse, demonstrating the urgent need for new treatment options. Therefore, we aimed to identify cell su
This chapter takes the fall of the Berlin Wall as its point of departure, and from there it traces a trajectory of unforeseen developments that have led from the erstwhile global optimism to the dramatic shift in mood just three short decades later. The key questions posed are: What global developments that were unforeseen then can account for the much more sombre ambience, pessimism or even alarm
Colour polymorphism can be maintained by colour morph-specific benefits across environmental conditions. Currently, the amount and the duration of snow cover during winter decrease especially in northern latitudes, which can alter the potential for camouflage of animals with light and dark morphs. Tawny owls, Strix aluco, are colour-polymorphic avian predators with dark (brown) and light (grey) co
This study examines trait-level sense of self in 32 participants with varying meditation experience, with a special focus on the sense of self-boundaries and the sense of being a subject of experience, what is here referred to as perspectival ownership of experience. Results from qualitative and quantitative analyses of in-depth phenomenological interviews suggested a quadratic relation between se
Around the world, paid work without appropriate structural support is a key barrier to optimal breastfeeding practices. To better protect, promote, and support optimal breastfeeding practices among working women in Africa, this scoping review sought to understand how paid work influences infant feeding practices in the first 6 mo of life and what support women need to manage work and optimal infan
In this work, we use a time-warping-based morphology variation index, d_{w}, computed between the peak and the end of the T-wave, and assess its association with the occurrence of ventricular fibrillation (VF) episodes in ischemic conditions. ECG recordings from 26 pigs under-going a 40-minute coronary occlusion were analyzed. The d_{w} series was obtained by quantifying the morphological differen
Background: General practitioners (GPs) should regularly review patients’ medications and, if necessary, deprescribe, as inappropriate polypharmacy may harm patients’ health. However, deprescribing can be challenging for physicians. This study investigates GPs’ deprescribing decisions in 31 countries. Methods: In this case vignette study, GPs were invited to participate in an online survey contain
The aim was to develop a short version of the Swedish Process of Recovery Questionnaire (QPR-Swe) for use with people with severe mental illness and to investigate its internal consistency, construct validity, known-groups validity and any floor or ceiling effects. Two independent samples were used, the first (N = 226) to develop the short version and the second (N = 266) to test its psychometric
Agricultural land use is a major driver of biodiversity losses and changes in ecosystem services. Thus, for the sake of both humans and wild organism per se, effective strategies that enable both agricultural production and conservation of biodiversity and ecosystem services are urgently needed. Such strategies can be divided into those that reduce the intensity of farming in general (such as orga
Virtual reality headsets, such as the HTC Vive, can be used to model objects, forces, and interactions between objects with high perceived realism and accuracy. Moreover, they can accurately track movements of the head and the hands. This combination makes it possible to provide subjects with precise quantitative feedback on their performance while they are learning a motor task. Juggling is a cha
Analytical chemistry is a sub-discipline of chemistry that even young schoolchildren encounter at an early stage in their education. Gravimetry and measurement uncertainties are aspects that form a part of such education, as well as measurements of pH and colorimetry. These are all an integral part of children’s early educational experiences, which shows the importance of this discipline within th
Working actively to engage service users in participatory practices is both a policy expectation and a moral imperative for mental health social workers in contemporary Western mental health care. Recent research suggests that such practices of service user involvement are becoming increasingly individualised and driven by market logic. Based on an ethnographic study within a Swedish public psychi
The Sagittarius dwarf spheroidal (Sgr dSph) galaxy is currently being accreted and disrupted by the tidal field of the Milky Way. Recent observations have shown that the central region of the dwarf hosts at least three different stellar populations, ranging from old and metal-poor over intermediate metal-rich to young metal-rich. While the intermediate-age metal-rich population has been identified
Portugal's real income per head grew by a factor of eight during the second half of the twentieth century, a period of fast convergence towards Western European living standards. We use a new sample of about 3,400 infants and children living in Lisbon to document trends in the prevalence of stunting and wasting between 1906 and 1994. We find that stunting and wasting fell quickly from around 1950,
Cross-sectional transmission electron microscopy (XTEM), including high-resolution microscopy (HREM), was employed to characterize the interface between different amorphous hydrogenated carbon (a-C:H) films and steel substrates. Additional analyses using Auger electron spectroscopy (AES) and X-ray diffraction (XRD) were also performed. Films were deposited both by high-energy (50 keV) nitrogen ion
In a large case-control study of Swedish incident type I diabetes patients and controls, 0–34 years of age, we tested the hypothesis that the GIMAP5 gene, a key genetic factor for lymphopenia in spontaneous BioBreeding rat diabetes, is associated with type I diabetes; with islet autoantibodies in incident type I diabetes patients or with age at clinical onset in incident type I diabetes patients.
