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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 192434 hits

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We study the magnetic Laplacian in a two-dimensional exterior domain with Neumann boundary condition and uniform magnetic field. For the exterior of the disk we establish accurate asymptotics of the low-lying eigenvalues in the weak magnetic field limit. For the exterior of a star-shaped domain, we obtain an asymptotic upper bound on the lowest eigenvalue in the weak field limit, involving the 4-m

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To Alan Walmsley, at sixty-fiveJarash (also Jerash, Greek Gerasa) ranks among the principal urban centres of Late Antique and Early Islamic Jordan. Despite being one of the most intensively investigated urban sites within the region, the history of Jarash during the Islamic ages, in particular after the massive earthquake of 749, remains a topic of profound disagreement. Drawing on previously unpu

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We report on the discovery and spectroscopic confirmation of TOI-2458 b, a transiting mini-Neptune around an F-type star leaving the main-sequence with a mass of M∗ = 1.05 ± 0.03 M⊙, a radius of R∗ = 1.31 ± 0.03 R⊙, an effective temperature of Teff = 6005 ± 50 K, and a metallicity of 0.10 ± 0.05 dex. By combining TESS photometry with high-resolution spectra acquired with the HARPS spectrograph, we

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An additional upsurge in bacterial STIs has been observed in Sweden following HIV pre-exposure prophylaxis (PrEP) implementation. From a prevention perspective, it is of relevance to optimize testing strategies within PrEP programmes to identify those most at risk. An open retrospective longitudinal observational cohort study was performed at three STI clinics in Uppsala, Gothenburg, and Malmö. A

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This thesis explores the challenges and advancements in high-dimensional Bayesian optimization (HDBO), focusing on understanding, quantifying, and improving optimization techniques in high-dimensional spaces.Bayesian optimization (BO) is a powerful method for optimizing expensive black-box functions, but its effectiveness diminishes as the dimensionality of the search space increases due to the cu

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Songbird migration involves frequent migratory flights interrupted by several days of stopover to refuel. For first-year migratory birds, this entails stopping in unfamiliar locations to exploit local resources and maximise fuelling rates. However, stopovers also pose mortality risks due to predator presence. We aimed to determine whether auditory cues from avian predators with differing hunting s

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The membranous ER spans the entire cell, creating a network for the biosynthesis of proteins and lipids, cell-wide communication, and nuclear delivery of molecules, including therapeutic agents. Here, we identify a novel ER response triggered by the tumoricidal complex alpha1-oleate, defined by a loss of peripheral ER structure, extensive ER vesiculation. Alpha1-oleate was present in the ER-derive

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Albeit costly, flight allows birds to travel great distances in a short time, making it a highly effective mode of locomotion, especially during migration.1,2 Understanding how birds use energy during flight is essential for studying their flight ecology.3 To fly, birds flap their wings, accelerating surrounding air and generating flight forces, where the rate of energy added to the wake represent

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This paper contains a theoretically and empirically based analysis of infrastructures and co-operational patterns in a Scandinavian Internet consulting company. The purpose of the analysis originated from the hypothesis that Web-based Information Systems could especially facilitate work in distributed organisations, this as a platform for supporting collaboration, communication and co-ordination w

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In recent years, a growing body of research has studied the effects of social network sites on various aspects of politics. However, little attention has been spent on how social network sites are used internally in political parties, and how they affect the perceived tension between the hierarchical structure of the political party and the network-based communication becoming more common and tech