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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 193907 hits

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The MAX IV storage rings, currently under construction in Lund, Sweden, will use third harmonic cavities operated passively to lengthen the bunches and alleviate collective instabilities. These cavities are an essential ingredient in the MAX IV design concept and are required for achieving the final design goals in terms of stored current, beam emittance, and beam lifetime-such performance challen

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Previously, it was shown that the cell-membrane-expressed glycosphingolipid, globotriaosylceramide (Gb(3)/P-k/CD77), protects against HIV-1 infection and may be a newly described natural resistance factor against HIV infection. We have now investigated the potential of a novel, water soluble, non-toxic and completely synthetic analogue of Gb(3)/P-k (FSL-Gb(3)) to inhibit HIV-1 infection in vitro.

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Popular Abstract in Swedish Avhandlingen utgår från förhållandet att mödradödligheten traditionellt varit en tungt vägande faktor för kvinnors totala sjukdomsbörda i låginkomstländer. Mödradödligheten är starkt knuten till såväl allmänna levnadsförhållanden i samhället som till tillgång och kvalitet av professionell hälsovård. Det är därför inte förvånande att mer än 99 av 100 mödradödsfall i värlMaternal health services are the least equitable health care services in most low- and middle-income countries. Improving maternal health in Ghana continues to be a major public health challenge. Socio-economic inequalities within the country are greatly reducing the use of maternal health care services despite government policy reforms to improve access to maternal health care services and interv

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Degradation of vegetation and soil erosion has contributed to loss of biological productivity and land degradation in Iceland. This thesis focuses on spatial and temporal patterns of land degradation in Iceland from a geographical perspective both along short and long timescales. The activity of current degradational processes has been assessed by studying farmers' perception of the problem and co

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An affinity-assay was developed that is based on the modulation of the diffusion coefficient of a redox-labelled hapten upon complementary recognition of the analyte leading to an increase of molecular weight and hence to a decrease of the diffusion coefficient. The slower diffusion is monitored by means of cyclic voltammetry. In order to demonstrate the feasibility of this assay format, recogniti

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In humans, beta-alanine (BAL) and the neurotransmitter gamma-aminobutyrate (GABA) are transaminated by a single aminotransferase enzyme. Apparently, yeast originally also had a single enzyme, but the corresponding gene was duplicated in the Saccharomyces kluyveri lineage. SkUGA1 encodes a homologue of Saccharomyces cerevisiae GABA aminotransferase, and SkPYD4 encodes an enzyme involved in both BAL

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Congenital haemophilia A and B are genetic disorders affecting factor VIII and factor IX production, respectively. Factor replacement is the only effective treatment for these deficiencies, but a patient's immune system can develop inhibitory antibodies which bind and interfere with the function of the replaced factor in a variety of ways. The main treatment goal for patients with inhibitors is to

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In terrestrial organisms, sensitivity to the Earth's magnetic field is mediated by at least two different magnetoreception mechanisms, one involving biogenic ferromagnetic crystals (magnetite/maghemite) and the second involving a photo-induced biochemical reaction that forms long-lasting, spin-coordinated, radical pair intermediates. In some vertebrate groups (amphibians and birds), both mechanism

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We sought to determine whether the COMT val158met polymorphism (rs4680) is associated with delusions and hallucinations in people with dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). A total of 218 individuals, recruited from centres in Norway, Sweden and the UK were included in this study; 121 with clinically or neuropathologically diagnosed DLB/PDD and 97 age-matched, cog

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To explain reciprocity, direct or indirect, several proximate mechanisms have been proposed, yet little attention has been given to the specific underlying cognitive mechanisms. Regardless of what proximate rules underlie reciprocity, some kind of memory would be paramount. Corvids in general, and ravens, Corvus corax, specifically, have been shown to possess an array of sophisticated cognitive me

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Background Collagenous colitis (CC) is by definition a histological diagnosis. However, colonoscopy often reveals characteristic endoscopic findings. The aim of this study was to evaluate the frequency and type of endoscopic findings in patients diagnosed with CC in 4 participating centers. Methods This was a retrospective study; the databases of 2 university hospitals in Edinburgh (Scotland) and

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Aggregation of dispersed rod-like particles like nanocellulose can improve the strength and rigidity of percolated networks but may also have a detrimental effect on the foamability. However, it should be possible to improve the strength of nanocellulose foams by multivalent ion-induced aggregation if the aggregation occurs after the foam has been formed. Lightweight and highly porous foams based

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Antihaemophilic-factor-A-antibodies, which had spontaneously arisen in 2 patients, were used to develop an immunoradiometric method for measurement of antihaemophilic factor A antigen (VIII:CAg). 13 patients with severe haemophilia A had VIII: CAg below the limit of detection (0.01 U/ml). Patients with moderate and mild haemophilia A either had VIII:CAg roughly equal to factor VIII clotting activi

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This study addresses the enduring problem of the mismatch between firms' offerings and consumers' desires. It combines the general framework of modernity theory with the concept of regimes and uses the food area as the empirical context. Our cultural analytical study of consumers' and firms' articulation of values of food and meal demonstrates that firms are largely entrenched in the modern era, c