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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 192328 hits

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Nitrification-denitrification process, which is the most commonly used method for nitrogen removal from wastewaters, is energy demanding and contributes very much to the the carbon footprint of wastewater treatment. One of the alternative methods for nitrogen removal is the nitritation-anammox process. Nitritation-anammox has been implemented successfully in sludge liquor streams and industrial wa

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Armenia started the disability policy reforms since the ratification of the UN CRPD in 2010. The final laws however were adopted only in 2021 and are not fully in force till now. The objective of this study is to comprehensively investigate the influence of international development agendas on national policy-shaping. Additionally, the study seeks to gain a nuanced understanding of the complex pro

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We studied islet function in mice with beta-cell-targeted expression of a dominant-negative mutant of hepatocyte nuclear factor (HNF)-1alpha. At age 2-3 months, anesthetized transgenic and wild-type male mice underwent an intravenous glucose (1 g/kg) tolerance test (IVGTT). It was found that transgenic mice had an abolished insulin response in association with severe glucose intolerance. In other

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The aim of this study was to assess the effect of the N, P and K status on frost sensitivity of Norway spruce needles in a fertilization experiment situated in a nutrient poor 29-year-old Picea abies stand in western Denmark. The relative difference in frost sensitivity among trees was assessed by an index of injury, based on conductivity measurements of ion leakage from needles. Despite fertiliza

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Thylakoids from the green alga, Dunaliella salina, were fragmented by sonication and the appressed grasna membranes separated from stroma lamellae by partitioning in aqueous two-phase systems. The concentration and antenna size of Photosystem I in the two membrane domains were determined for cultures grown at three different light intensities. Although the antenna size of both PS is decreased with

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Objective-To examine whether DNA microarray analysis of chromosomal susceptibility regions for allergy can help to identify candidate genes. Material and Methods-Nasal biopsies were obtained from 23 patients with allergic rhinitis and 12 healthy controls. RNA was extracted from the biopsies and pooled into three patient and three control pools. These were then analysed in duplicate with DNA microa

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In this study, we examined the onset and duration of local analgesic effects of bupivacaine incorporated into biodegradable microcapsules (extended-duration local anesthetic; EDLA) administered as subcutaneous infiltrations in different doses in humans. In 18 volunteers, the skin on the medial calf was infiltrated with 10 mL of EDLA, and the opposite calf was infiltrated with 10 mL of aqueous bupi

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The expansion of ecotourism around the world brings about certain structural transformations as it moves. When ecotourism is conceptualized as frictions, the transformations open up the analytical perspective for a broader understanding. Seemingly dispersed acts can be connected to wider structural shifts in the social reproduction. Studying global process like ecotourism ethnographically requir

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Problemdiskussion: Sektorn för olja och gas är inte särskilt mogen när det gäller kunskapen om försörjningskedjor. Det valda företaget för fallstudien, Maersk Drilling (MD), har problem med ett splittrat IT-­landskap och dålig datakvalitet. Det har orsakat problem med ineffektiva och komplexa processer där det krävs onödig kommunikation, parallell inmatning av data, etc. Inom upphandlingar och inkProblem Discussion: The oil and gas sector is not very mature in terms of supply chain management. The chosen case company, Maersk Drilling (MD), has problems with a split IT-­landscape with poor data quality. It has caused problems with inefficient and complex processes with much communication required, parallel information and more. Within procurement it translates to problems in spend managemen

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In the last decade a new and alternative source of geospatial data has become available, so called Volunteered Geographic Information (VGI). Private individuals voluntarily collect large amount of geographic data for a joint project. This data are usually free under certain licence restrictions. One of the most well known examples of VGI is the OpenStreetMap (OSM) project. Due to its increasing p

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Since the 1980s, the Borough of Brent, in north-west London, has been a major global hub of transnational Twelver Shiism. With the influx of Iraqi refugees, many clerical leaders of Twelver Shia Islam established their European headquarters in Brent, and, in addition to Damascus and Tehran, London became a major centre of Iraqi diaspora politics during Saddam Hussein’s regime. The transnational ne

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Binding between protein molecules on contacting cells is essential in initiating and regulating several key biological processes. In contrast to interactions between molecules in solution, these events are restricted to the two-dimensional (2D) plane of the meeting cell surfaces. However, converting between the more commonly available binding kinetics measured in solution and the so-called 2D bind

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Tight binding models are widely used in large scale electronic structure calculations of nanostructures. Their atomistic nature makes them flexible, but also means the computational cost increases rapidly with system size. The large number of calculations required to design nanostructures makes computational efficiency desirable. We have developed a method to increase computational speed while ret

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Most natural antisense RNAs display a high degree ofsecondary structure with stem-loops as their mostprominent feature. Mutations affecting the Inhibitoryactivity of these RNAs most often map in or close toloop regions in both the antisense and target RNAs.The primary recognition loops often contain 5- 7unpaired nucleotldes. Nucleotide changes in the loopsaffect the binding rate and, hence, the in

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Using a case study of the Búrfell wind farm project, a large wind farm proposed in the Central Highlands of Iceland, the authors attempt to provide new insights into the factors shaping subjective landscape perceptions and attitudes to renewable energy developments, and into alternative methods that may be used for their assessment. The research was based on an on-site visit and actual experience

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Background Joint damage in rheumatoid arthritis (RA) remains a significant problem. Identification of biomarkers associated with joint destruction can improve our understanding of underlying disease processes and future management.Objectives To evaluate inflammatory proteins as potential predictors of radiographic progression of joint damage.Methods Consecutive early RA patients (symptom duration

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Background: Amplification of 1q (amp(1q); ≥4 1q copies) has repeatedly been reported to predict a worse outcome in multiple myeloma (MM), whereas the impact of gain of 1q (gain(1q); three 1q copies) is less clear. Methods: We investigated survival of MM in relation to amp(1q) and gain(1q) by retrospectively analysing 346 consecutively newly diagnosed MM (NDMM) patients. Of these, 62 (18%) had amp(