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Microbial degradation of lignin and its related aromatic compounds has great potential for the sustainable production of chemicals and bioremediation of contaminated soils. We previously isolated Pseudomonas sp. strain 9.1 from historical waste deposits (forming so-called fiber banks) released from pulp and paper mills along the Baltic Sea coast. The strain accumulated vanillyl alcohol during grow
Background: Hypoxic-ischaemic encephalopathy (HIE) is a leading cause of mortality and long-term neurological sequelae, affecting thousands of children worldwide. Current therapies to treat HIE are limited to cooling. Stem cell-based therapies offer a potential therapeutic approach to repair or regenerate injured brain tissue. These preclinical findings have now culminated in ongoing human neonata
Aims: The population of immigrants from the Middle East in Sweden show a higher prevalence of type 2 diabetes (T2D) compared to native Swedes. The exact reason for this is unknown. Here, we have performed metabolite profiling to investigate these differences. Methods: Metabolite profiling was conducted in Iraqi immigrants (n = 93) and native Swedes (n = 77) using two complementary mass spectrometr
INTRODUCTION: This article describes the views of European rural general practitioners regarding the strengths, weaknesses, opportunities and threats (SWOT) of the implementation of a chronic care model (CCM) in European rural primary care. METHODS: This was a mixed-methods online survey. Data were collected from 227 general practitioners between May and December 2017. Categorical data were analys
Background: We examined whether molecular characterization of high-grade epithelial ovarian cancer can inform the diagnosis and/or identify potential actionable targets. Methods: All of the consecutively sequenced high-grade ovarian tumours with consent between 2014 until 2019 were included. A total of 274 tumours underwent next generation sequencing using a targeted panel. Results: Patients with
BACKGROUND: The behaviour of blood-sucking arthropods is a crucial determinant of blood protozoan distribution and hence of host-parasite coevolution, but it is very challenging to study in the wild. The molecular identification of parasite lineages in vectors can be a useful key to understand the behaviour and transmission patterns realised by these vectors. METHODS: In this study, we collected b
Purpose: This paper aims to unveil how sustainability is integrated into the courses/programmes of higher education institutions. The research question addressed is: how do academics representing different disciplines cooperate and engage in the work of integrating sustainability into their teaching programmes. Design/methodology/approach: This paper draws upon the notions of practise variation an
Background: Spironucleus salmonicida is an anaerobic parasite that can cause systemic infections in Atlantic salmon. Unlike other diplomonad parasites, such as the human pathogen Giardia intestinalis, Spironucleus species can infiltrate the blood stream of their hosts eventually colonizing organs, skin and gills. How this presumed anaerobe can persist and invade oxygenated tissues, despite having
Bruton's tyrosine kinase (Btk) is encoded by the gene that when mutated causes the primary immunodeficiency disease X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (Xid) in mice. Btk is a member of the Tec family of protein tyrosine kinases (PTKs) and plays a vital, but diverse, modulatory role in many cellular processes. Mutations affecting Btk block B-lymphocyte develop
Widespread losses of production and conservation values make large-scale ecosystem restoration increasingly urgent. Ecological restoration by means of biomanipulation, i.e., by fishing out planktivores to reduce the predation pressure on herbivorous zooplankton, has proved to be an effective tool in restoring degraded lakes and coastal ecosystems. Whether biomanipulation may prove a useful restora
The ideal free distribution (IFD) model predicts that consumers match the distribution of resources across habitat patches and that this association should lead to equal individual fitness among individuals in a population. Here we studied to what extent predators utilize different prey groups and if the resulting spatial patterns relate to the reproductive success of individuals in a population o
Background: Proteases of human pathogens are becoming increasingly important drug targets, hence it is necessary to understand their substrate specificity and to interpret this knowledge in practically useful ways. New methods are being developed that produce large amounts of cleavage information for individual proteases and some have been applied to extract cleavage rules from data. However, the
This thesis reports the results from a pollen analytical and quantitative landscape reconstruction (REVEALS model) study in the drainage area of the Botorpsströmmen River in southern Sweden as a part of the project The archaeology and ecology of collapse: social and agricultural change following the Black Death and the project Managing Multiple Stressors in the Baltic Sea. The focus of this study
Indonesia, as per their stance on the Paris Agreement and social development goals (SDG), has been on a winding journey to meet their renewable energy targets. In providing the national electricity, the state electricity company (PLN) is still deriving more than 70% of its energy sources from coal and oil As per 2018, only up to 8% of on-grid power is generated from renewable energy sources, and t
Efficient and effective environmental information processing is a key element for the improvement of an organization‘s environmental performance. Business Information Systems (BIS) are recognized as a tool for the facilitation of collecting, storing, processing and communicating any kind of information. However, there are other benefits that BIS can provide for a company. These benefits are relate
Partly attributed to the distinguishing effects of poverty on education and effects of education on poverty, the poverty and education nexus is complex. Since poverty is a multidimensional phenomenon deprivation in education, especially in urban slums, is not caused by one factor alone, but is rather stitched to various other related factors such as family structure, a high conflict neighbourhood
Buildings account for 40% of energy use and about one third of CO2 emissions in the EU. The huge energy saving potentials offered by the building sector has been targeted by a large number of policy instruments. To improve policy intervention in this area, more information on the extent to which the applied policy instruments are supporting the development and dissemination of different types of e
