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This PhD project aimed to investigate cerebellar contribution to cognition from a translational perspective by integrating neuropsychological assessment and neuroimaging, incorporating neurocognitive and motor tests with 7T Magnetic resonance imaging (MRI). The results are clinically significant as they identify nonverbal cognitive deficits that often may go unnoticed in clinical practice, particu
Raloxifene reduces vertebral fracture risk in postmenopausal women with osteoporosis and established osteoporosis, but its efficacy in women with osteopenia has not been studied. The objective of this study was to evaluate the effect of raloxifene hydrochloride on the risk of vertebral fractures in postmenopausal women with osteopenia and to compare this effect with that in women with osteoporosis
Considering the frequent use of mobile phones, we have directed attention to possible implications on cognitive functions. In this study we investigated in a rat model the long-term effects of protracted exposure to Global System for Mobile Communication-900 MHz (GSM-900) radiation. Out of a total of 56 rats, 32 were exposed for 2 h each week for 55 weeks to radio-frequency electromagnetic radiati
Deoxycytidine kinase (dCK) and deoxyguanosine kinase (dGK) catalyze the first step in the intracellular cascade of fludarabine (2-fluoroadenine-beta-D-arabinofuranoside) and cladribine (2-chlorodeoxyadenosine) phosphorylation, which leads to activation of these prodrugs, commonly used for treatment of chronic lymphocytic leukemia (CLL). Thus, resistance to nucleoside analogues may primarily be due
Aim: To test the reliability, validity and sensitivity of the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-MY24 questionnaire, designed to assess the quality of life of myeloma patients with the QLQ-C30. Methods: The study was carried out through the EORTC Quality of Life Group using clinical trials in seven countries. All trials used the QLQ-C30 and QLQ-MY24 at baseline
This doctorate thesis focuses on sparse regression, a statistical modeling tool for selecting valuable predictors in underdetermined linear models. By imposing different constraints on the structure of the variable vector in the regression problem, one obtains estimates which have sparse supports, i.e., where only a few of the elements in the response variable have non-zero values. The thesis coll
We demonstrate a tool for identifying, prioritizing and evaluating vulnerabilities in software. The tool aims to improve security in products by making maintenance more efficient and robust. Software components and release versions are matched with vulnerability information from open resources. The results are visualized on several different levels, ranging from product portfolio and individual pr
Context. X-ray extragalactic surveys are ideal laboratories for the study of the evolution and clustering of active galactic nuclei (AGN). Usually, a combination of deep and wide surveys is necessary to create a complete picture of the population. Deep X-ray surveys provide the faint population at high redshift, while wide surveys provide the rare bright sources. Nevertheless, very wide area surve
The human copper exporters ATP7A and ATP7B contain domains common to all P-type ATPases as well as class-specific features such as six sequential heavy-metal binding domains (HMBD1-HMBD6) and a type-specific constellation of transmembrane helices. Despite the medical significance of ATP7A and ATP7B related to Menkes and Wilson diseases, respectively, structural information has only been available
Objectives: To investigate gender differences in daily smoking prevalence in different age groups in southern Sweden. Methods: The 2004 public-health survey in Skåne is a cross-sectional study. A total of 27,757 persons aged 18-80 years answered a postal questionnaire, which represents 59% of the random sample. A logistic regression model was used to investigate the associations between gender and
A chronology based on optically stimulated luminescence (OSL) dating is presented for the late- and post-glacial evolution of the southern Baltic Sea (-15ka to present). During this period, large water level and salinity changes occurred in the Baltic Basin due to opening and closing of connections to the North Atlantic. Previous attempts to establish a chronology for these palaeoenvironmental cha
Background: Deinstitutionalisation has led to many people with serious mental illness spending most of their time outside psychiatric institutions. Not much is known about their subjective life. The paper presents the results of analysis of self-esteem in a group of non-institutionalised people with schizophrenia. Methods: Interviews were conducted with random samples of people with schizophrenia
OBJECTIVE: To explore the utility of cluster analysis in defining complex dietary exposures, separately with two types of variables. DESIGN:: A modified diet history method, combining a 7-day menu book and a 168-item questionnaire, assessed dietary habits. A standardized questionnaire collected information on sociodemographics, lifestyle and health history. Anthropometric information was obtained
The objective of this study was the investigation of the maximal potential donor pool and causes of non-realized organ donation. On-site retrospective medical-record review was performed for all cases of patient death (n=1608) occurring in 1999 at 34 (83% of all) intensive care units (ICUs) in the region of the transplant center in Prague, Czech Republic. Two hundred and eighty-eight (18%) patient
The aims of this study were to investigate the frequency of dysphagia among patients with acute stroke and compare non-dysphagic and dysphagic stroke patients regarding demographic aspects, performance in activities of daily living and type of neurological deficiency and to test a bedside screening tool to identify patients with dysphagia. The frequency of dysphagia was found to be 27%, or 40% if
Popular Abstract in Swedish Schizofreni är en kronisk och handikappande sjukdom som karakteriseras av allvarliga men fluktuerande symtom, med återkommande akuta episoder. Sjukdomen är förknippad med reducerad kognitiv och social funktionsförmåga. Patienterna vilka i regel insjuknar i unga år, bibehåller vanligtvis kvarstående restsymtom och därmed associerade stigma fram till ålderdomen. Det överObjective: To explore the long-term course and to study factors of potential relevance for the treatment and rehabilitation process of patients with schizophrenia and schizophrenia-like disorders. Specific issues concerned cognitive reduction, tardive dyskinesia (TD), prolactin-induced side effects, remission and lack of insight. Method: A naturalistic multicenter study of 225 patients, diagnosed
This paper describes a search for beyond the Standard Model decays of the Higgs boson into a pair of new spin-0 particles subsequently decaying into b-quark pairs, H→aa→(bb¯)(bb¯), using proton-proton collision data collected by the ATLAS detector at the Large Hadron Collider at center-of-mass energy s=13 TeV. This search focuses on the range 15 GeV≤ma≤30 GeV, where the decay products are collimat
Microbial degradation of lignin and its related aromatic compounds has great potential for the sustainable production of chemicals and bioremediation of contaminated soils. We previously isolated Pseudomonas sp. strain 9.1 from historical waste deposits (forming so-called fiber banks) released from pulp and paper mills along the Baltic Sea coast. The strain accumulated vanillyl alcohol during grow
Background: Hypoxic-ischaemic encephalopathy (HIE) is a leading cause of mortality and long-term neurological sequelae, affecting thousands of children worldwide. Current therapies to treat HIE are limited to cooling. Stem cell-based therapies offer a potential therapeutic approach to repair or regenerate injured brain tissue. These preclinical findings have now culminated in ongoing human neonata
