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Objective: Invasive treatment of intermittent claudication (IC) is commonly performed, despite limited evidence of its cost effectiveness. IC symptoms are mainly caused by atherosclerotic lesions in the superficial femoral artery (SFA), and endovascular treatment is performed frequently. The aim of this study was to investigate its cost effectiveness vs. non-invasive treatment. Methods: One hundre
The Research Institute for Fragrance Materials, Inc. (RIFM) has been engaged in the generation and evaluation of safety data for fragrance materials since its inception over 45 years ago. Over time, RIFM's approach to gathering data, estimating exposure and assessing safety has evolved as the tools for risk assessment evolved. This publication is designed to update the RIFM safety assessment proce
Popular Abstract in Swedish Mikroorganismer finns runt omkring oss i miljön och mycket tyder på att de påverkar oss mer, och delvis på ett annat sätt, än vi tidigare trott. Vi vet alla att infektioner kan spridas genom inandning av luftburna patogena mikroorganismer. Men luftburna mikrober kan även ge andra sjukdomar. Det är t.ex välkänt att lantbrukare riskerar att drabbas av symptom i luftvägarnMicroorganisms are ubiquitous in indoor air and epidemiological data suggest that inhalation of microbes and/or their products adhered on air–borne dust particles can impair well–being and health. In the present thesis microbial volatile organic compounds (MVOCs) and cellular markers were studied by gas chromatography–mass spectrometry (GC/MS). By using solid phase microextraction (SPME) combined
Context. The inner disc, which links the thin disc with the bulge, has been somewhat neglected in the past because of the intrinsic difficulties in its study, among which crowding and high extinction. Open clusters located in the inner disc are among the best tracers of its chemistry at different ages and distances. Aims. We analyse the chemical patterns of four open clusters located within 7 kpc
OBJECTIVES: Cyclophosphamide (CP) is an alkylating agent classified as a human carcinogen. Health care workers handling this drug may be exposed during, e.g., preparation or administration. Cyclophosphamide is readily absorbed by inhalation and by dermal uptake. A biomarker, CP in urine, has frequently been used to assess the occupational exposure to CP, but has not been fully validated. The aim o
Supply risk management (SRM) is a well-established aspect in the field of supply chain management (SCM) that has gained even more relevance due to the ongoing covid-19 pandemic. Many articles have been published relating to the topic, such as Norrman and Jansson (2004) and Zsidisin (2003a). To ensure the academic contribution of this thesis, the authors specifically focused on SRM for companies pr
Populärvetenskaplig sammanfattning: Naturbetesmarkerna minskade med 86,7% från 1927 till 1990. Denna minskning är alarmerande eftersom många idag hotade och sällsynta arter är beroende av dessa. En stor del av anledningen till detta är att staten ända in på 1980-talet i sin rådgivning danade för att dessa marker antingen skulle bearbetas med konstgödsel och ogräsbekämpning eller planteras med trädThe rural landscape of Sweden has changed rapidly during the 20:th century. Measurements from 1927 compared to those from 1990 show that the area of non managed pasture in Sweden has declined by 86.7 %. Since a lot of threatened and rare species are dependent of this kind of land, these figures are alarming. During the last 30-40 years non managed pasture has declined due to abandonment, tree plan
Efficient and effective environmental information processing is a key element for the improvement of an organization‘s environmental performance. Business Information Systems (BIS) are recognized as a tool for the facilitation of collecting, storing, processing and communicating any kind of information. However, there are other benefits that BIS can provide for a company. These benefits are relate
BACKGROUND: This study aimed to evaluate the prevalence of pathogenic/likely pathogenic cardiomyopathy variant carriers in a multiancestry US population and examine the risk of adverse clinical outcomes. METHODS: This retrospective cohort study included multiancestry US adults aged ≥18 years with sequencing data from the All of Us Research Program. Pathogenic/likely pathogenic variants in cardiomy
Aim: Rare genetic variants in the CUBN gene encoding the main albumin-transporter in the proximal tubule of the kidneys have previously been associated with microalbuminuria and higher urine albumin levels, also in diabetes. Sequencing studies in isolated proteinuria suggest that these variants might not affect kidney function, despite proteinuria. However, the relation of these CUBN missense vari
The aim of this study was to describe experiences of physical activity, perceived meaning and importance of, and motives and barriers for participation in physical activity, among people 80 years of age and older. A qualitative design with focus-group methodology was used. The sample consisted of 20 community-living people aged 80-91 years. Data analyses revealed four themes: physical activity as
The aim of this Master's thesis is to study the public library identity from a brand perspective, how the public library brand identitity is communicated through blogs and what is communicated in them. The authors analyse the public library identity through selected concepts and a model within Aaker´s and Kapferer´s branding theories. These theories have been applied on literature and blogs a
For the first time in the latest Assessment Report of the Intergovernmental Panel on Climate Change (IPCC), water has been the focus of dedicated chapters in both Working Group 1 (Chapter 8) and 2 (Chapter 4). Nevertheless, we argue here that water has not yet received the full attention it deserves from both scientists and policymakers for several reasons. Firstly, the historical focus on tempera
Mikroskopi är idag ett fundamentalt verktyg inom forskning, där det tillåter oss att skåda in och utforska våra prover i hög detalj. Mycket utav utvecklingen av nya mikroskopimetoder har strävat efter att öka den detaljnivå vi kan uppnå. Samtidigt har utvecklingen inom hårdvara, med tillgång till bättre och mer kraftfulla instrument, lett till utveckligen av metoder där fokuset är att studera en h
This article focuses on the role of actor relations in advancing climate policymaking and argues that attempts to understand decisions to decarbonise in a green state should explore the institutional conditions for policymaking. The article explores the climate policy model in Sweden in terms of the societal actors included in the policy process, the nature of this inclusion, and its relevance for
Background & Aims: There is an unclear association between intake of fish and long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFAs) and colorectal cancer (CRC). We examined the association between fish consumption, dietary and circulating levels of n-3 LC-PUFAs, and ratio of n-6:n-3 LC-PUFA with CRC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) coh
The base-catalyzed dehydration of benzene cis-1,2-dihydrodiols is driven by formation of an aromatic product as well as intermediates potentially stabilized by hyperaromaticity. Experiments exhibit surprising shifts in isotope effects, indicating an unusual mechanistic balance on the E2-E1cB continuum. In this study, both 1- and 2-dimensional free energy surfaces are generated for these compounds
The last years of turbulence on the market caused by the pandemic and geo-political tensions have led to supply disruptions for many companies. The purpose of this study was to investigate how digital purchasing practices and trust are impacted in the supply chain due to increased turbulence in the environment. This was carried out through an interview study with buyers and sellers in supply chain
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that is associated with allergic comorbidities. However, studies examining comorbidities in childhood AD are incomplete, which may contribute to suboptimal care. Objective: The objective was to compare the risk of developing different allergic and non-allergic comorbidities among children with AD to that of a matched non-AD
