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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 193162 hits

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Endwall film cooling is a significant cooling method to protect the endwall region and the junction region of endwall and a turbine vane, where usually a relatively high temperature load exists. This work aims to find the optimized arrangement of film cooling holes on the endwall and improve the film cooling in some difficult regions on the endwall, such as pressure side-endwall junction region. S

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This article presents several sport clubs in Finland connected to an organization Idrottsförening Kamraterna (Sporting Society Comrades), also known as IFK that originated in Sweden in 1895. The idea of IFK clubs reached Finland in 1897 and spread throughout the country. The beginning of the twentieth century was a period of growth and expansion for IFK, both in Sweden and Finland. IFK clubs forme

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Lipid nanodiscs can be used to solubilize functional membrane proteins (MPs) in nativelike environments. Thus, they are promising reagents that have been proven useful to characterize MPs. Both protein and non-protein molecular belts have shown promise to maintain the structural integrity of MPs in lipid nanodiscs. Small-angle neutron scattering (SANS) can be used to determine low-resolution struc

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Oral direct inhibitors (ODIs) of thrombin and factor Xa are now approved as anticoagulant drugs. The first two drugs to complete phase III clinical trials for thromboprophylaxis in orthopaedic surgery and treatment of patients with atrial fibrillation or venous thromboembolism were dabigatran and rivaroxaban. These small molecules are given at fixed dose with no requirement for monitoring as pharm

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In the present paper I will demonstrate the history of Raqqa’s cultural heritage, its floruit and its destruction, from its resettlement in the 19th century until the “Islamic State” period. I will also discuss the recent situation and the challenges to heritage associated with post-war construction in Raqqa. Raqqa was the summer capital of the caliph Harun Al Rashid and the centre of government f

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Preclinical rodent models of Parkinson’s Disease (PD) based on alpha-synuclein (αSyn) present some of the pathological hallmarks of the human condition, such as the progressive loss of dopaminergic neurons in the substantia nigra (SN) and the development of behavioural deficits. However, numerous reports on these models highlighted the variable outcomes that might originate from them if not valida

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We present the direct stabilization of the CEP of a high-repetition rate OPCPA by employing a Stereo-ATI pulsemeter for single-shot detection and feedback to the oscillator at the full OPCPA repetition rate.

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This study regards a Child Play-and-Learn Area (CPLA) in a library as a third place and investigates its relationships with visitors through the concept of place attachment. To understand the influence of the CPLA, the study examined the relationships among visitors' place attachment, servicescape and behavioural intentions involving place scales. A survey was conducted in a CPLA in Christchurch,

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Today's Carrier-Envelope Phase (CEP) stabilizations of mode-locked oscillators widely used in attosecond science and frequency metrology rely on octave spanning frequency combs and the detection of beating between the blue end and the frequency doubled red end of the same spectrum. This technique was established by the seminal works of Hänsch and co-workers [1], demonstrating the stabilization of

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We discuss the motion of a rectangular camphor boat, considering the position of a camphor pill in relation to the boat's stern as the control parameter. The boat moves because the pill releases surface active molecules that decrease the surface tension and support the motion. We introduce a new experimental system in which the boat rotates on a long arm around the axis located at the centre of a

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Enzyme regulation is vital for metabolic adaptability in living systems. Fine control of enzyme activity is often delivered through post-translational mechanisms, such as allostery or allokairy. β-phosphoglucomutase (βPGM) from Lactococcus lactis is a phosphoryl transfer enzyme required for complete catabolism of trehalose and maltose, through the isomerisation of β-glucose 1-phosphate to glucose

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The popularity of digital gaming among older adults is on the rise, necessitating a deeper understanding of this phenomenon. Drawing upon the concepts and theoretical perspectives in domestication theory, actor network theory, and media engagement theory, we explored the digital gameplay experiences of older adults in China’s sociocultural contexts. We conducted in-depth interviews with 12 adults

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This article assesses the tension between cosmopolitan and communitarian approaches to the ethics of migration by analysing how the Protestant Church in Germany (EKD) has responded to the current so-called migration crisis in Europe. I argue that the statements of the EKD frame people on the move either as migrants or as Muslims. These frames come with competing ethical consequences. Whereas migra

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Background: Ovarian torsion is a gynecological surgical emergency whose diagnosis remains a challenge. Torsion occurs most frequently in women of reproductive age. It is usually associated with the presence of benign masses in the ovary, as malignant tumors are less frequent and less prone to undergo torsion. Case presentation: We report the case of a 17-year-old Caucasian patient who presented to

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This paper presents preparations, execution and reflection on results for the physics part of a CSI task for the European Union Science Olympiad 2010, taking place at the University of Gothenburg. The participants were required to make a graph of the cooling of a swede (Brassicanapus), as a proxy for the cooling of a murder victim, and to choose a mathematical expression for the cooling curve, as

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The pace-of-life syndrome (POLS) hypothesis predicts that behavior and physiology covary with life history. Evidence for such covariation is contradictory, possibly because systematic sources of variation (e.g. sex) have been neglected. Sexes often experience different selection pressures leading to sex-specific allocation between reproduction and self-maintenance, facilitating divergence in life-

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Absorption and emission of light is studied theoretically for excited atoms in coherent superposition of states subjected to isolated attosecond pulses in the extreme ultraviolet range. A gauge-invariant formulation of transient absorption theory is motivated using the energy operator from Yang's gauge theory. The interaction, which simultaneously couples both bound and continuum states, is simula

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This paper discusses the prospect of a sociology of science informed by the critical realist philosophy of science. The discussion departs from the need for a theoretical framework to account for theoretical struggle and reproduction in the field of econom-ics. The recent talk about an ontological turn in science studies and the wider back-ground for such a turn is then related to the earlier turn

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This thesis is based on the results concerning the epitaxial growth and characterization of silicon (Si) and germanium (Ge) nanostructures. The growth technique was the Ultra High Vacuum Chemical Vapor Deposition (UHV-CVD) that works in relatively low temperatures and low growth pressures. The UHV-CVD chamber was also used for the reduction experiments. The work presented here involves three diff