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Background: Isothiazolinones are widely used as preservatives in both cosmetic and non-cosmetic products. Sensitisation to isothiazolinones other than chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT), present in the baseline series, is increasing. Objectives: To investigate the prevalence of sensitisation to benzisothiazolinone (BIT) in comparison to CMIT/MIT and to develop a product-i
Neurofilament light chain (NfL) is a promising biomarker of axonal injury across acute and chronic neurodegeneration, which can improve drug discovery and disease monitoring models. Traditional in vivo animal models cannot fully mimic human pathophysiology of neurodegenerative diseases (NDDs), but in vitro models based on human cells solve this problem, reducing the time and cost of drug testing.
The increasing prevalence of insecticidal products containing mixtures of active ingredients has highlighted the need for computational approaches to predict the insecticidal activity at specific dose combinations. Several models predicting the interactions have been proposed, each based on different assumption regarding mixture toxicity. However, the lack of consensus on which model to adopt for
The urgency of addressing climate change has underscored the need for precise carbon management—an approach that precisely monitors, assesses, and manages carbon emissions and sequestration at fine spatial, temporal, and sectoral scales. This perspective paper examines the current state of precise carbon management, highlighting advancements in ground-based observations, remote sensing, process-ba
Populärvetenskaplig sammanfattning: Under alla tider har planeten Jorden genomgått en naturlig klimat variation. Utöver denna naturliga variation i klimatet, så har människan, under det senaste århundradet, medverkat till en ökning av växthusgaser i atmosfären. Detta kan innebära att växthuseffekten intensifieras och Jorden bli utsatt för onaturliga temperaturökningar. Koldioxid (CO2), från bland In the context of climate change, it is important to understand how the terrestrial carbon cycle is interacting with the anthropogenic increase in atmospheric carbon dioxide (CO2) concentration. Boreal and subarctic regions in the northern hemisphere are great carbon pools, as well as they are subject to predicted warming. These facts place them in the absolute frontline of ecosystems that are to
Fairtrade represents a small but rapidly growing share of the world market. This paper discusses Fairtrade impact on the coffee value chain. Both Fairtrade and the coffee value chain link together the producer and the consumer. This is of importance as the geographical distance between where most coffee is produced and consumed can be great and level development often varies widely. In Northern co
Tropical forests provide essential ecosystem services, playing a critical role in climate regulation, biodiversity conservation, and regional hydrological cycles while also supporting livelihoods. However, they are increasingly threatened by deforestation and land-use change. Accurate land cover (LC) mapping is vital to monitor these changes, but mapping tropical forests is challenging due to comp
Abstract in German: Aus der Sicht der byzantinischen Quellen scheint ein religiöser Konfrontationsansatz mit dem Islam oft zu fehlen; dort werden die Muslime als “Araber”, “Sarazenen”, “Ismaeliten” oder “Hagarener” genannt, wie man die vorislamischen Araber auch bezeichnet hatte. Es ist damit nicht ganz klar, wie die universalistische Ansprüche des frühen Islam von Byzanz aus zu verstehen sind. EsByzantine sources often seem to ignore the religious cause of controversy with Islam: they refer to Muslims as “Arabs”, “Saracens”, “Ismaelites” or “Hagarenes”, names which had already been used to denote the pre-Islamic Arabs. The Byzantine point of observation on the universalist claims of Early Islam is, thus, not quite clear. There are, however, several clues to the assumption that the early C
The integration of peer support workers (PSW) into the mental health services workforce has offered additional avenues to strengthen service provision. In Sweden, the availability of peer support workers has grown significantly over the past decade, yet there has been insufficient investigation into their organization and implementation. Consequently, there is a growing need for further research i
Background: In Sweden, dental care for children and adolescents, including specialist orthodontic treatment, is publicly funded. This study aims to analyze the impact of sociodemographic factors on the distribution of publicly funded specialist orthodontic treatment in a mid-sized Swedish region. Methods: A registry-based cohort study was conducted in Region Östergötland, including individuals bor
In septic shock, administration of large fluid volumes is associated with poor outcomes. Recent evidence shows that non-resuscitation fluids are the major modifiable source of fluids for patients with septic shock in intensive care units (ICUs). This clinical trial is designed to test the hypothesis that restrictive administration of non-resuscitation fluids improves outcomes compared to usual car
Business model innovation (BMI) plays a key role in driving sustainability transitions, yet its interplay with the broader socio-technical system is often overlooked. This study investigates BMI in the emerging niche of insect-based food and feed in Sweden, employing a combined Business Model Design Space (BMDS) and dynamic capabilities perspective. Drawing on interviews with ten insect firms, we
The growing global population has increased the demand for circular sanitation solutions that enhance energy and nutrient recovery. Anaerobic digestion (AD) of blackwater (BW) offers a promising solution, but its application in full-scale UASB reactors remains unexplored. This study evaluated the performance of a full-scale UASB (50 m3) treating BW collected from a new city district (Oceanhamnen)
Many studies report on the association between 2D:4D, a putative marker for prenatal testosterone exposure, and economic preferences. However, most of these studies have limited sample sizes and test multiple hypotheses (without preregistration). In this study we mainly replicate the common specifications found in the literature for the association between the 2D:4D ratio and risk taking, the will
ObjectivesTransdiagnostic models aim to uncover shared mechanisms across mental disorders. Reward responsiveness (the ability to experience pleasure from rewarding stimuli) is a plausible, yet underexplored, transdiagnostic mechanism linking obsessive-compulsive disorder (OCD) and depression. This study used network analysis to (1) examine how key reward responsiveness domains are interlinked in i
Physiologically based pharmacokinetic (PBPK) models offer the ability to simulate and predict the biodistribution of radiopharmaceuticals and have the potential to enable individualised treatment planning in molecular radiotherapy. The objective of this study was to develop and implement a whole-body compartmental PBPK model for peptide receptor radionuclide therapy (PRRT) with [177Lu]Lu-DOTA-TATE
The encoding of goal-oriented motion events varies across different languages. Speakers of languages without grammatical aspect (e.g., Swedish) tend to mention motion endpoints when describing events (e.g., “two nuns walk to a house”) and attach importance to event endpoints when matching scenes from memory. Speakers of aspect languages (e.g., English), on the other hand, are more prone to direct
