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Introduction: HIV guidelines recommend switching from a three-drug regimen (3DR) to dolutegravir + lamivudine (DTG+3TC) for eligible individuals. This retrospective national cohort study used Swedish InfCareHIV registry data to evaluate long-term outcomes of adults with HIV RNA <50 copies/ml who switched to DTG+3TC or a guideline-recommended 3DR between July 2019 and May 2023 in routine clinical c
Introduction: Strengthening Primary Health Care (PHC) is essential for building resilient and equitable health systems, but PHC faces barriers in implementation, resource allocation, and political prioritisation. This study aimed to develop a strategic roadmap to enhance PHC by identifying core values, priorities, and actionable strategies through expert consensus. Methods: A two-round Delphi stud
Globally, a substantial number of children experience various forms of parental maltreatment. Child protection agencies work to support these children and prevent further abuse or neglect, often through targeted interventions directed at the parents. Previous research has indicated that social workers may approach male and female perpetrators of maltreatment differently once a case is reported. To
The evolution of male courtship rituals has traditionally been attributed to female mate selection, but may also hinge on male investment strategies in sexually cannibalistic species. In many spiders, males perform energetically costly courtship rituals to increase acceptance by females and minimise the risk of sexual cannibalism. However, due to sperm competition, males may invest less energy whe
Carbon capture and storage (CCS) has in recent years gained increasing attention as a climate solution. In Denmark, geological CO2-storage was earlier rejected, but in 2020 CCS was incorporated into national climate policy as key to reach the country’s 2030 target. In this article we investigate the incorporation of CCS into Danish climate policy as a case of mitigation deterrence. Through the con
Abstract INTRODUCTION Countries have varying, limited healthcare budgets for emerging disease-modifying therapies. Cost-effectiveness analysis, combined with country-level cost-effectiveness thresholds, can be used to estimate value-based prices (VBPs) for lecanemab and donanemab across 174 countries. METHODS The cost-effectiveness of lecanemab and donanemab was estimated using incremental cost an
Background: Isothiazolinones are widely used as preservatives in both cosmetic and non-cosmetic products. Sensitisation to isothiazolinones other than chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT), present in the baseline series, is increasing. Objectives: To investigate the prevalence of sensitisation to benzisothiazolinone (BIT) in comparison to CMIT/MIT and to develop a product-i
Neurofilament light chain (NfL) is a promising biomarker of axonal injury across acute and chronic neurodegeneration, which can improve drug discovery and disease monitoring models. Traditional in vivo animal models cannot fully mimic human pathophysiology of neurodegenerative diseases (NDDs), but in vitro models based on human cells solve this problem, reducing the time and cost of drug testing.
Abstract Study regionThree mid-high latitude catchments include the Krycklan (Boreal Sweden), the Danube (Central Europe) and the Mississippi (USA).Study focusWe develop a hybrid eco-hydrological framework that couples the process-based terrestrial ecosystem model LPJ-GUESS (Lund-Potsdam-Jena General Ecosystem Simulator) with five machine-learning (ML) algorithms through two hybrid model structure
Populärvetenskaplig sammanfattning: Under alla tider har planeten Jorden genomgått en naturlig klimat variation. Utöver denna naturliga variation i klimatet, så har människan, under det senaste århundradet, medverkat till en ökning av växthusgaser i atmosfären. Detta kan innebära att växthuseffekten intensifieras och Jorden bli utsatt för onaturliga temperaturökningar. Koldioxid (CO2), från bland In the context of climate change, it is important to understand how the terrestrial carbon cycle is interacting with the anthropogenic increase in atmospheric carbon dioxide (CO2) concentration. Boreal and subarctic regions in the northern hemisphere are great carbon pools, as well as they are subject to predicted warming. These facts place them in the absolute frontline of ecosystems that are to
Fairtrade represents a small but rapidly growing share of the world market. This paper discusses Fairtrade impact on the coffee value chain. Both Fairtrade and the coffee value chain link together the producer and the consumer. This is of importance as the geographical distance between where most coffee is produced and consumed can be great and level development often varies widely. In Northern co
The integration of peer support workers (PSW) into the mental health services workforce has offered additional avenues to strengthen service provision. In Sweden, the availability of peer support workers has grown significantly over the past decade, yet there has been insufficient investigation into their organization and implementation. Consequently, there is a growing need for further research i
Background: In Sweden, dental care for children and adolescents, including specialist orthodontic treatment, is publicly funded. This study aims to analyze the impact of sociodemographic factors on the distribution of publicly funded specialist orthodontic treatment in a mid-sized Swedish region. Methods: A registry-based cohort study was conducted in Region Östergötland, including individuals bor
In septic shock, administration of large fluid volumes is associated with poor outcomes. Recent evidence shows that non-resuscitation fluids are the major modifiable source of fluids for patients with septic shock in intensive care units (ICUs). This clinical trial is designed to test the hypothesis that restrictive administration of non-resuscitation fluids improves outcomes compared to usual car
Business model innovation (BMI) plays a key role in driving sustainability transitions, yet its interplay with the broader socio-technical system is often overlooked. This study investigates BMI in the emerging niche of insect-based food and feed in Sweden, employing a combined Business Model Design Space (BMDS) and dynamic capabilities perspective. Drawing on interviews with ten insect firms, we
The growing global population has increased the demand for circular sanitation solutions that enhance energy and nutrient recovery. Anaerobic digestion (AD) of blackwater (BW) offers a promising solution, but its application in full-scale UASB reactors remains unexplored. This study evaluated the performance of a full-scale UASB (50 m3) treating BW collected from a new city district (Oceanhamnen)
