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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 192174 hits
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Background Childhood cancer has been associated with long-term risk of urinary tract diseases, but risk patterns remain to be comprehensively investigated. We analysed the lifetime risk of urinary tract diseases in survivors of childhood cancer in the Nordic countries. Methods We identified 32,519 one-year survivors of childhood cancer diagnosed since the 1940s and 1950s in the five Nordic cancer
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As part of the development of the beam imaging system at the European Spallation Source, luminescent screens have been fabricated by the flame spraying of scintillating materials onto stainless steel backings. A total of seven screens were produced, three of chromia alumina (Al2O3:Cr), two of YAG (Y3Al5O12:Ce) and two of a 50/50 mix of these. The properties of these screens under proton irradiatio
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Photography was born at the beginning of the 19th century as a tool for representing the world around us. With its advent, the scientific community found an ally to push back the frontiers of knowledge. Since then, the pairing of photography and science has evolved considerably. Photography has positioned itself not only as an effective means of collecting data, but also as a tool for sharing scie
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Mitochondrial metabolism is entirely dependent on the biosynthesis of the [4Fe-4S] clusters, which are part of the subunits of the respiratory chain. The mitochondrial late ISC pathway mediates the formation of these clusters from simpler [2Fe-2S] molecules and transfers them to client proteins. Here, we characterized the late ISC pathway in one of the simplest mitochondria, mitosomes, of the anae
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INTRODUCTION: Although hospitals are key health service providers, their financial ties to drug companies are little understood. We examine non-research pharmaceutical industry payments to English National Health Service (NHS) trusts-hospital groupings providing secondary and tertiary care.METHODS: We extracted data from the industry-run Disclosure UK database, analysing it descriptively and using
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Models based on the Ornstein-Uhlenbeck process have become standard for the comparative study of adaptation. Cooper et al. (2016) have cast doubt on this practice by claiming statistical problems with fitting Ornstein-Uhlenbeck models to comparative data. Specifically, they claim that statistical tests of Brownian motion may have too high Type I error rates and that such error rates are exacerbate
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Background: Impaired social cognition (SC) occurs frequently in schizophrenia (SCZ), yet compared to autism spectrum disorder (ASD), the research on SC in SCZ is sparse and methodologically heterogeneous. To accurately assess between-group SC differences it is further necessary to establish the relationship between nonsocial cognition (NSC) and SC, particularly as this may not be identical across
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As a research field, social movement and political project, degrowth is a multi-faceted phenomenon. It brings together a range of practices including alternative forms of living and initiatives of various kinds in civil society, business and the state. Yet no comprehensive theory of degrowth transformations has so far been developed. Deep transformations fills this gap. It develops a theory of deg
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This chapter strikes a bridge from current-day imaginations to pre-modern concepts of empire. It shows how, on the one hand, modern visions of empire are echoing political and religious notions of an all-encompassing rule that go back to Antiquity. On the other hand, it stresses how such modern conceptualizations tend to fall short on understanding diversity in a world where state penetration and
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Decolonisation aims at exposing the ills of colonialism in an attempt to undo their long-standing effects. Important criticism of curriculum decolonisation has focused on potential conflicts with academic freedom. However, this criticism has to some extent suffered from a perceived lack of agreement on the concept and status of academic freedom itself. The present study views decolonisation in Sou
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Multidrug-resistant tuberculosis (MDR) continues to pose a threat to public health. Previously, we identified a cationic host defense peptide with activity against Mycobacterium tuberculosis in vivo and with a bactericidal effect against MDR M. tuberculosis at therapeutic concentrations. To understand the mechanisms of this peptide, we investigated its interactions with live M. tuberculosis and li
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BACKGROUND: Pyogenic liver abscess (PLA) is a rare but potentially life-threatening disease, and estimates suggest a gradual increase in the incidence during the last decades. The primary aim of this study was to report the incidence, trend and aetiology of PLA during a decade in Southern Sweden.METHODS: This was a population-based observational cohort study between 2011 and 2020 in Skåne, Souther
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Wetlands are facing gradual drying, leading to large carbon loss due to the transformation from anaerobic to aerobic conditions, but the temperature and drought effects from the temperature and moisture fluctuation on soil organic carbon (SOC) mineralization remain uncertain. An incubation study with three moisture levels (100%, 60%, and 40% WHC, marked as W100, W60, and W40, respectively) and fou
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This dissertation explores and compares the rationalities through which Danish state officials sought to govern the colonized Afro-Caribbean population in the colony of the Danish West Indies and the state’s Danish subjects living in the metropole of Denmark in the period 1770-1900. Theoretically, it relies upon Michel Foucault’s conception of ’governmentality’ and the way this approach to governi
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BackgroundLoss to follow-up (LTFU) from tuberculosis (TB) treatment and care is a major public health problem as patients can be infectious and also may develop a multi-drug resistant TB (MDR-TB). The study aimed to assess whether LTFU differs by the distance TB patients travelled to receive care from the nearest health facility.MethodsA total of 402 patient cards of TB patients who received care
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The "Make, reuse, repair, recycle" is an alternative model to the the linear model "Take, make, waste" and aims to reduce the environmental impact of home deliveries, particularly by reducing the packaging waste. This model was tested in a real-life context in which the secondary packaging was returned and reuse multiple times. This model sets the scene to more circular and sustainable last-mile
