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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 193159 hits

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Chronic pancreatitis is a relatively frequent condition usually caused by alcoholic abuse but also due to recurrent gallstone disease, metabolic endocrine disorders and haemochromatosis, among others. Specific types such as hereditary and autoimmune pancreatitis should be particularly kept in mind and emphasized, as they require specific treatment and attention. The possibility to identify gene mu

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Basque is spoken by approximately 660,000 people (Trask 1997) in the Basque Country, straddling the border between northern Spain and southern France, particularly in rural areas of the Bizkaia and Gipuzkoa coastline, as well as inland Gipuzkoa and the foothills of the Pyrenees in Navarre. Virtually all Basque speakers are bilingual with either Spanish or French. Nevertheless, Basque is, due to it

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In patients undergoing peritoneal dialysis (PD) for end-stage renal failure, the optimum electrolyte composition of a dialysis solution is that which best serves the homeostatic needs of the body. Comparing the transperitoneal removal of electrolytes by conventional PD solutions (CPDSs) with that by normal kidneys, it is evident that peritoneal removal is in the lower range of what can be consider

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When distributed to different artefacts, the self appears in a multitude of shapes, characterized not only by its materiality but also by the necessity to preserve at least an illusion of a core self. The experience of a continuous evolution of these overlapping “selves”, many of which are materialized together with others’ overlapping selves, cannot be captured by traditional design approaches, n

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Fuel economy and emissions are the two central parameters in heavy duty engines; most of the existing heavy duty engines are run with diesel. The overall efficiency of diesel engines is good however they suffer from high levels of emissions mainly NOX and soot. Using alternative fuels like Natural-Gas has shown to be a good way to reduce emissions level. Diesel engines can be easily converted to N

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The main contribution of this work is a novel numerical characterization of a DNA sequence based on the 2-D graphical representation of DNA introduced by Yau et al. [12]. We construct a 3-tuple of the normalized leading eigenvalues of the Q matrices associated with the three characteristic curves of a DNA sequence. The approach is illustrated with an examination of dissimilarities of exon-1 of bet

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“Can an engineer, using a current simulation modelling programs, produce evacuation flow rates of a live emergency evacuation a priori to the analyses of the evacuation?” The above question is explored with reference to previous pre-evacuation modelling attempts and a new series of “small-scale” underground train evacuation experiments conducted under the METRO research project. METRO is concerne

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Scandoromani: Remnants of a Mixed Language is the first, comprehensive, international description of the language of the Swedish and Norwegian Romano, also labeled resande/reisende. The language, an official minority language in Sweden and Norway, has a history in Scandinavia going back to the early 16th century. A mixed language of Romani and Scandinavian, it is spoken today by a vanishingly smal

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Health care expenditures have increased rapidly in most OECD-countries, and several reforms have been considered for the improvement of cost-containment in the health care sector. Physicians in particular have been recognized to have considerable impact on health care expenditures and as a result they have become increasingly involved in budgetary control with the hope of a more efficient use of r

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We introduce a new notion of independence based on the Borel-Cantelli lemma. We study this characteristic in the context of i.i.d. stochastic processes and processes driven by equilibrium dynamics.

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The azimuthal distributions of photons and charged particles with respect to the event plane are investigated as a function of centrality in Pb-208 + Pb-208 collisions at 158 (.) A GeV/c in the WA98 experiment at the CERN SPS. The anisotropy of the azimuthal distributions is characterized using a Fourier analysis. For both the photon and charged particle distributions the first two Fourier coeffic

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The three-dimensional circulation, salinity distribution, and overall transport pattern were simulated in the Pearl River Estuary, China, using a modified version of the Princeton Ocean Model (POM). The circulation in the estuary is mainly driven by tide, wind, and river runoff in a complex manner, where the relative importance of the different forcing factors varies over the year. Field data on c

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The purpose of the article is to describe and compare the purchasing process for advanced versus basic logistics services. Further some specific observations are presented from the procurement of advanced third-party logistics services, with respect to service definitions, providers evaluations and contracts. The purchasing process of logistics services will in the future need to be more different

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Objective To estimate the cost-effectiveness of a new treatment (natalizumab) for multiple sclerosis (MS) compared with current standard therapy with disease-modifying drugs (DMDs) in Sweden. Methods A Markov model was constructed to illustrate disease progression based on functional disability (the Expanded Disability Status Scale (EDSS)). The effectiveness of natalizumab was based on a 2-year cl