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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 193123 hits

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This paper reviews the factors influencing the development and sustained operation of regional industrial symbiosis (IS) networks and discusses the roles a coordination body can play to alter these factors so as to catalyse the development and functioning of such networks. These are analysed within the context of experiences gained in the early stages of three regional IS programmes under developm

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Background: We evaluated the efficacy and safety of low-dose budesonide/formoterol, 80 mug/4.5 mug, bid in a single inhaler (Symbicort Turbuhaler; AstraZeneca; Lund, Sweden) compared with an increased dose of budesonide, 200 mug bid, in adult patients with mild-to-moderate asthma not fully controlled on low doses of inhaled corticosteroid alone. Methods: All patients received budesonide, 100 jig b

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The aim of the study was to examine the effects of wearing an ice-vest (ca 1 kg) on physiological and subjective responses in fire fighters. The experiments were carried out on a treadmill in a hot-dry environment. The physical cooling effect of the ice-vest was measured with a thermal manikin. The ice-vest effectively reduced skin temperatures under the vest. On average, heart rate was 10 beats m

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In the Baltic Sea, floating blooms of nitrogen-fixing cyanobacteria occur yearly during late summer. These blooms can sometimes be limited by iron. Due to extensive foresting around the Baltic Sea, iron is entering the Baltic Sea partly bound to dissolved organic material (DOM) via rivers. An experiment was performed in 300 1 laboratory mesocosms to test the hypothesis that riverine high-molecular

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Background: Iceland's geographical isolation with a stable and small population gives a rare opportunity for follow-up studies of medical interventions. Total hip replacements (THR) have been done at FSA Central Hospital in Akureyri, Iceland since 1982 with the Exeter hip implant being in use from the beginning. Methods: Hospital records for all patients operated on with THR between 1982 and the e

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This paper presents the design and validation of a universal 6D seam tracking system that reduces the need of accurate robot trajectory programming and geometrical databases in robotic laser scanning. The 6D seam tracking system was developed in the flexible unified simulation environment, integrating software prototyping with mechanical virtual prototyping, based on physical experiments, The vali

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To investigate subjective and objective changes in function in subjects with Parkinson's disease (PD) home visits with interviews were performed with a 1-year interval. Depressive symptoms were rated with the Geriatric Depression Scale, subjective health with the generic SF-36 scale and the disease-specific PDQ-8 scale; objective changes were assessed according to the Hoehn and Yahr scale; insomni

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Children's utilization of curative care was studied to analyse the division of responsibilities between undifferentiated primary care and specialized care. All chronically ill (n = 510), a control group (n = 287) and the total population 0-15 years of age (n = 6080) in a primary care district were studied using register data. Chronically ill children comprised 8.4% of the total child population an

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OBJECTIVE: To explore conceptions of obstetric emergency care among traditional birth attendants in rural Guatemala, elucidating social and cultural factors. STUDY: design Qualitative in-depth interview study. SETTING: Rural Guatemala. SAMPLE: Thirteen traditional birth attendants from 11 villages around San Miguel Ixtahuacán, Guatemala. METHOD: Interviews with semi-structured, thematic, open-ende

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The effect of a second mutant allele (V1991, here denoted rn*) at the PRKAG3 (RN) locus on carcass composition was determined in 334 pigs, entire males and females, from crosses between Swedish Hampshire (H) and Finnish Landrace (L) (H x LH; LH x H; LH x LH). Pigs were classified according to DNA test into the following PRKAG3 genotypes: RN-IRN- (23%), RN-/rn(-) (24%), RN-/rn* (33%), rn(+)/rn(+) (

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The prevalence of antibiotic resistance and their genetic determinants in colonizing group B streptococci (GBS) sampled in a Swedish nationwide survey was examined. In five GBS isolates (1.3%), kanamycin/amikacin resistance and the presence of the aphA-3 gene was identified. Three of these isolates carried the aad-6 gene and were streptomycin-resistant. Screening with kanamycin and streptomycin 1,

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The association between vitamin D status and hepatocellular carcinoma (HCC) has not been well investigated, despite experimental evidence supporting an important role of vitamin D in liver pathophysiology. Our objective was to investigate the association between prediagnostic circulating 25-hydroxyvitamin D [25(OH)D] serum levels and the risk of HCC in a prospective, nested case-control study amon

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Background: There is insufficient information regarding the benefit of treatment with curative intent for men with localised poorly differentiated prostate cancer (PCa). Objective: To evaluate relative survival in men with potentially curable PCa in relation to Gleason score (GS) and treatment as practiced in the community at large. Design, setting, and participants: A population-based study inclu

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When developing software platforms for product lines, decisions on which features to implement are affected by factors such as changing markets and evolving technologies. Effective scoping thus requires continuous assessment of how changes in the domain impact scoping decisions. Decisions may have to be changed as circumstances change, resulting in a dynamic evolution of the scope of software asse

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The intensity of a fire is an important factor determining the recovery of soil microorganisms after a forest fire, since it can alter the quality and quantity of carbon sources. Recovery of the microbial community was studied in a Mediterranean pine forest soil subjected to different temperatures to simulate the short-term effects of fire intensity on bacterial and fungal growth, estimated using

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Burkitt lymphoma (BL) is a rare neoplasm constituting 1-2% of adult lymphomas. Our aims in this study were to establish prognostic factors for overall survival in adult BL and evaluate the efficacy of different chemotherapy regimens in a population based setting. The study population was collected from the Swedish Lymphoma Registry 2000-2010. During this period, 156 adult patients with BL were ide