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Protein S has an established role in the protein C anticoagulant pathway, where it enhances the factor Va (FVa) and factor VIIIa (FVIIIa) inactivating property of activated protein C (APC). Despite its physiological role and clinical importance, the molecular basis of its action is not fully understood. To clarify the mechanism of the protein S interaction with APC, we have constructed and express
To evaluate treatment outcome in a large population-based cohort of patients with anal cancer treated according to Nordic guidelines.
A vertical gate symmetrical molecular transistor is demonstrated. It includes self assembled monolayer of ferrocene molecules chemically bonded to be a flat Au source and Au nanoparticles drain electrodes while gated with the central gate electrode. Using this configuration, we show that negative differential resistance, symmetrical behavior, and rectification effects can be tuned by controlling t
The diffusion behavior of the conjugated polyelectrolyte poly{[9,9-bis(6'-N,N,N-trimethylammonium)hexyl]fluorene-phenylene) bromide (HTMA-PFP) with different molecular weights has been studied in dimethyl sulfoxide (DMSO) + water solutions. Samples of HTMA-PFP with various molecular weights were obtained by synthesis of poly[9,9-bis(6'-bromohexyl)fluorene-phenylene] via a Suzuki coupling reaction,
Unilateral intrastriatal and intra-medial forebrain bundle injections of 6-OHDA impair the performance in a lateralised choice reaction time task. However, the extent and pattern of deficits after nigral 6-OHDA injections is less well studied, as well as the impact of training regime or the modification of various task parameters. The nigral 6-OHDA lesion resulted in impaired response accuracy and
This note provides a generalization of a recent result by Jarvenpaa, Jarvenpaa, Koivusalo, Li, and Suomala (to appear) on the dimension of limsup-sets of random coverings of tori. The result in this note is stronger in the sense that it provides also a large intersection property of the limsup-sets, the assumptions are weaker, and it implies the result of Jarvenpaa, Jarvenpaa, Koivusalo, Li, and S
Heat transfer and pressure drop characteristics of Al2O3/water and MWCNT/water nanofluids flowing in a chevron-type plate heat exchanger were experimentally investigated and compared with those of water. Results showed that heat transfer seemed to be improved by using nanofluids at constant Reynolds number. However, little heat transfer enhancement was observed based on a constant flow velocity. T
The association between breast cancer and warfarin is inconclusive as most previous studies examined their association using patients with thromboembolism, whereas thromboembolism itself is a risk factor for cancer. We explored this issue using patients received mechanical heart valves replacement as a proxy for warfarin exposure as these patients need a lifelong warfarin treatment, and compared t
Understanding how a pathogen colonizes and adapts to a new host environment is a primary aim in studying emerging infectious diseases. Adaptive mutations arise among the thousands of variants generated during RNA virus infection, and identifying these variants will shed light onto how changes in tropism and species jumps can occur. Here, we adapted Coxsackie virus B3 to a highly permissive and les
The photon-number statistics from resonance fluorescence of a two-level atom near a metal nanosphere driven by a laser field with finite bandwidth is studied theoretically. Our analysis shows that all interesting physics here takes place in a small area around the nanosphere where the near field and the atom-nanosphere coupling essentially affect the radiative properties of the atom. Computer mode
Background: Two new pneumococcal conjugate vaccines were licensed to immunize infants and young children against pneumococcal disease. Objectives: The objective of this study was to estimate the expected health benefits, costs, and incremental cost-effectiveness of routine vaccination with the 10-valent pneumococcal nontypeable hemophilus influenza protein-D conjugate vaccine (PHiD-CV) compared wi
The aim of this study was to investigate if preoperative measurements of the femoral valgus angle (FVA) affected the mechanical alignment, individual component positions and clinical outcome in total knee arthroplasty (TKA).
In order to explore consumer culture’s potential to change social relations, this investigation immerses into the growing consumer culture of foodies occupying the historically feminine space of domestic cooking. It offers a tentative theory on the entering of subordinate consumption fields in contexts where the entering is sanctioned by cultural authorities.
Gasoline partially premixed combustion (PPC) has shown potential in terms of high efficiency with low emissions of oxides of nitrogen (NOx) and soot. Despite these benefits, emissions of unburned hydrocarbons (UHC) and carbon monoxide (CO) are the main shortcomings of the concept. These are caused, among other things, by overlean zones near the injector tip and injector dribble. Previous diesel lo
The relay autotuner for PID control is based on the simple idea of investigating process dynamics by the oscillation obtained when the PID controller is replaced by a relay unction. In this paper an asymmetric relay function is used, which provides an equation for the static gain of the process. A method to find the normalized time delay is proposed and the benefits of this is discussed. Ways to f
Evidence of arterial pulse pressure variations caused by cardio-pulmonary interactions, and their connection to volume status via the Frank–Starling relationship, are well documented in the literature. Computation of pulse pressure variations from arterial pressure measurements is complicated by the fact that systolic and diastolic peaks are not evenly spaced in time. A robust, structurally uncomp
Using information from Swedish population registries, we attempt to decompose the shared environment (C) into four subcomponents: close family, family, household, and community. Among pairs differing in their genetic and geographical/household relationships, we examine three externalizing syndromes: drug abuse (DA), criminal behavior (CB), and alcohol use disorders (AUD). The best-fitting common p
