Filetype
Background/Objectives: The hallmark of cystic fibrosis (CF) is chronic lung inflammation. The severity of lung disease is closely correlated with immunoglobulin G (IgG) levels. Beyond its contribution to the bone health, the importance of vitamin D has not been fully recognized owing to the lack of human studies providing evidence of its benefit. In the context of the recently described immunomodu
Background and Aims: Spontaneous type 1 diabetes (T1D) in the BioBreeding (BB) rat mimics human T1D as the rats experience weight loss, polydipsia, polyuria, ketoacidosis, onset during puberty and insulin-dependency within a day after diagnosis. Because the DP rat develops T1D spontaneously, it is a prime laboratory animal for dissecting the genetics of T1D susceptibility without the need for exte
National guidelines are being produced at an increasing rate, and politicians and managers are expected to promote these guidelines and their implementation in clinical work. However, research seldom deals with how decision-makers can perceive these guidelines or their challenges in a cultural context. Therefore, the aim of this study was twofold: to investigate how well Promoting Action on Resear
CK2 is an extremely pleiotropic Ser/Thr protein kinase, responsible for the generation of a large proportion of the human phosphoproteome and implicated in a wide variety of biological functions. CK2 plays a global role as an anti-apoptotic agent, a property which is believed to partially account for the addiction of many cancer cells to high CK2 levels. To gain information about the CK2 targets w
We prove a T(1) theorem to completely characterize compact Calderon-Zygmund operators. The result provides sufficient and necessary conditions for the compactness of singular integral operators acting on L-p(R) with 1 < p < infinity. (C) 2015 Elsevier Masson SAS. All rights reserved.
Background The growing awareness of transfusion-associated morbidity and mortality necessitates investigations into the underlying mechanisms. Small animals have been the dominant transfusion model but have associated limitations. This study aimed to develop a comprehensive large animal (ovine) model of transfusion encompassing: blood collection, processing and storage, compatibility testing right
PURPOSE: To estimate the prevalence, genotype, and clinical spectrum of Best vitelliform macular dystrophy (Best disease). DESIGN: Retrospective epidemiologic and clinical and molecular genetic observational study. METHODS: SETTING: National referral center. PARTICIPANTS: Forty-five individuals diagnosed with Best disease. OBSERVATION PROCEDURES: Retrospective review of patients diagnosed accordin
Increased red cell distribution width (RDW) has been related to poor prognosis in patients with cardiovascular disease, and is a predictor of cardiovascular mortality in the general population. The purpose of the present study was to investigate if RDW is associated with increased incidence of stroke and its subtypes in individuals from the general population.
Narrow migration corridors known in diurnal, social migrants such as raptors, storks and geese are thought to be caused by topographical leading line effects in combination with learning detailed routes across generations. Here, we document narrow-front migration in a nocturnal, solitary migrant, the common cuckoo Cuculus canorus, using satellite telemetry. We tracked the migration of adult cuckoo
We observe that the recent quasi-polynomial time approximation scheme (QPTAS) of Adamaszek and Wiese for the Maximum Weight Independent Set of Polygons problem, where polygons have at most a polylogarithmic number of vertices and nonnegative weights, yields: 1. a QPTAS for the problem of finding, for a set S of n points in the plane, a planar straight-line graph (PSLG) whose vertices are the point
Musculoskeletal pain is highly prevalent throughout adulthood with a major impact on health, function and participation in the society. Still, the association between muscle strength and development of musculoskeletal pain is unclear. We aimed to study whether overall muscle strength in adolescent men is inversely associated with self-reported musculoskeletal pain in adulthood.
Neuroblastomas (NBs) are tumours of the sympathetic nervous system accounting for 8-10% of paediatric cancers. NBs exhibit extensive intertumour genetic heterogeneity, but their extent of intratumour genetic diversity has remained unexplored. We aimed to assess intratumour genetic variation in NBs with a focus on whole chromosome changes and their underlying mechanism. Allelic ratios obtained by S
Early detection of neonatal illness is an important step towards improving newborn survival. Every year an estimated 3.07 million children die during their first month of life and about one-third of these deaths occur during the first 24 hours. Ninety-eight percent of all neonatal deaths occur in low- and middle-income countries like Uganda. Inadequate progress has been made globally to reduce the
Excited state dynamics and electron transfer from the Ru(dcbpy)(2)(NCS)(2) (RuN3) sensitizer to semiconductor nanoparticles were studied using time-resolved femtosecond absorption spectroscopy. We found that excitation of the red wing of the absorption spectrum of the sensitizer populates the (MLCT)-M-3 state directly, both in solution and attached on semiconductor nanoparticle films. Electron inj
This paper reviews the 25-plus year history of significant developments of the GENESIS shoreline response model. Topics discussed are line sources and sinks of sand, representation of shore-normal structures including natural sand bypassing, wave transmission by and shoreline response to shore-parallel structures, seawalls, migrating longshore sand waves, seasonal variation by cross-shore sand tra
Utländska investerares egendom skyddas av internationell investeringsrätt, inom vilken systemet för internationella skiljeförfaranden mellan investerare och stater (internationella investeringstvister) har utvecklats. Baserat på investeringsavtal mellan stater, eller nationell lagstiftning, har investerare rätt att väcka talan om de anser att staten har underlåtit att fullgöra sina skyldigheter geForeign investors’ property is protected under international investment law, under which the system of investor-state arbitration has developed. Based on investment treaties between states, or national legislation, investors are granted the right to arbitrate if they believe that the state has failed to fulfill its obligations towards them. Under the current legal framework, investors are allowed
Soil microorganisms sequester carbon through growth and release it into the atmosphere through respiration. Climate change predictions suggest that high latitude ecosystems will be particularly affected by rising temperatures, and temperature is one of the main environmental factors regulating microbial activity in soils. Thus, understanding how microbial activity will be affected in temperate eco
