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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 193185 hits

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We consider thermal fluid structure interaction with a partitioned approach, where typically, a finite volume and a finite element code would be coupled. As a model problem, we consider two coupled Poisson problems with heat conductivities $$\lambda _1$$, $$\lambda _2$$ in one dimension on intervals of length $$l:1$$ and $$l:2$$. Hereby, we consider linear discretizations on arbitrary meshes, such

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Infection patterns of avian haemosporidians result from the evolution of their associations with hosts, and can be shaped by multiple biotic factors. However, at the level of parasite species, few studies have investigated the details of the temporal dynamics of infection patterns in wild bird communities. We hereby studied a wild bird community in southern Sweden to investigate two generalist par

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Drug resistance in viruses represents one of the major challenges of healthcare. As part of an effort to provide a treatment that avoids the possibility of drug resistance, we discovered a novel mechanism of action (MOA) and specific compounds to treat all nine human herpesviruses and animal herpesviruses. The novel MOA targets the pressurized genome state in a viral capsid, "turns off" capsid pre

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How blood parasite infections influence the migration of hosts remains a lively debated issue as past studies found negative, positive, or no response to infections. This particularly applies to small birds, for which monitoring of detailed migration behavior over a whole annual cycle has been technically unachievable so far. Here, we investigate how bird migration is influenced by parasite infect

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BACKGROUND AND AIMS: The homeostatic chemokines CCL21 and CCL19 have been explored as biomarkers in cardiovascular disease prediction in patients with established cardiovascular disease, but associations between these chemokines and first-time coronary event incidence have not been investigated before. Here, we explored associations between CCL21 or CCL19 and first-time incident coronary events in

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Tungsten is a prime candidate material for use in plasma facing components in nuclear fusion reactors. This would entail weathering extreme conditions, such as high thermal loads and particle bombardment. It is of vital importance to understand how tungsten mechanically responds to these conditions, and how it is impacted by the defects that form. The current communication considers how the mechan

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Speciation entails a reduction in gene flow between lineages. The rates at which genomic regions become isolated varies across space and time. Barrier markers are linked to putative genes involved in (processes of) reproductive isolation, and, when observed over two transects, indicate species-wide processes. In contrast, transect-specific putative barrier markers suggest local processes. We studi

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Contact nurses in cancer care were vital in sustaining cancer care in Sweden during the COVID-19 pandemic. The aim of this study was to investigate their experiences of providing care to people with cancer in these exceptional circumstances to identify emerging challenges and opportunities that must be addressed moving forward. A survey distributed to contact nurses was supplemented with questions

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In boreal forests an important part of the photo assimilates are allocated belowground to support symbiosis of ectomycorrhizal fungi (EMF). The production of EMF extramatrical mycelium can contribute to carbon (C) sequestration in soils, but the extent of this contribution depends on the composition of the EMF community. Some species can decrease soil C stocks by degrading soil organic matter (SOM

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A search for Higgs boson pair production in events with two b-jets and two τ-leptons is presented, using a proton–proton collision dataset with an integrated luminosity of 139 fb −1 collected at s = 13 TeV by the ATLAS experiment at the LHC. Higgs boson pairs produced non-resonantly or in the decay of a narrow scalar resonance in the mass range from 251 to 1600 GeV are targeted. Events in which at

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Large amounts of cellulose-based waste textiles are generated every year, yet little is done to recycle this waste. Alternatives such as fiber-to-fiber recycling, where a significant part of the value of the waste textiles is recovered, are attractive possibilities. In this study, we have investigated the viability of using hydrated zinc chloride (ZnCl2·4H2O) as a solvent and swelling agent to con

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Anthropocentrism and disciplinary research have not led to effective solutions to sustainability problems. A shift is required towards biocentric, transdisciplinarity-based solutions, to mitigate rebound effects and unintended, negative effects. In the field of Sustainable Supply Network Design, such shift implies on developing resilient solutions that maximize environmental benefits instead of mi

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Background and purpose: Various blood biomarkers reflecting brain amyloid-β (Aβ) load have recently been proposed with promising results. However, to date, no comparative study amongst blood biomarkers has been reported. Our objective was to examine the diagnostic performance and cost effectiveness of three blood biomarkers on the same cohort. Methods: Using the same cohort (n = 68), the performan

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Cancer is a complex disease with various genetic and epigenetic driving factors. Cancer cells form a favored microenvironment to sustain their uncontrolled behavior leading to abnormal growth. With standard treatment including chemotherapy, relapse risk is high due to the resistance that cancer cells can develop against chemotherapy agents. Immuno-oncological therapeutics, as alternatives, have sh

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The ongoing climate change can modulate the behavior of global vegetation and influence the terrestrial biosphere carbon sink. Past observation-based studies have mainly focused on the linear trend or interannual variability of the vegetation greenness, but could not explicitly deal with the effect of natural decadal variability due to the short length of observations. Here we put the variabilitie

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The development of a coherent sense of self as a teacher often emerges from tensions between multiple and competing identities. While grappling with these tensions can be stressful, and sometimes demoralizing, it is through disruption that spaces for development are provided. For preservice teachers, identity development can be supported through engagement with these processes. With a focus on con

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The breakup of drops is investigated in a scale-up model mimicking the flow in an emulsification device i.e., high-pressure homogenizer (HPH). The breakup phenomenon is investigated through experimental and numerical approaches. Both approaches have their own limitations, but together, one could have reliable conclusions on general and some specific questions about the breakup of drops in an indus