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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 192398 hits

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The oxidation of sulfite to sulfate by two different models of the active site of sulfite oxidase has been studied. Both protonated and deprotonated substrates were tested. Geometries were optimized with density functional theory (TPSS/def2-SV(P)) and energies were calculated either with hybrid functionals and large basis sets (B3LYP/def2-TZVPD) including corrections for dispersion, solvation, and

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The phenomenon of bribery is characterized by its elastic features, both morally and legally. This study sets out to investigate a court case of bribery: how the people involved construct and argue for their particular version. A single case of bribery is chosen in order to clarify the range and potential of various descriptions of the very same event. The material consists of interviews with the

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This research provides an overview of some of the frequently occurring themes in discussion of academic criticism toward child sponsorship with Swedish sponsorship staff. The study aims to provide a deeper understanding of child sponsorship, their purpose, and critique, than the one that can be draw from the existing literature which remains largely detached to the perspectives of the people on th

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Endometriosis is a chronic gynecological illness affecting 10% of all women in childbearing age, 200 000 of them in Sweden, causing abdominal inflammation and adhesion formation, all of which inflicts pain. It affects every aspect of a woman’s life, not the least psychologically, leading to anxiety, depression and decreased function and decreased quality of life. This online survey explored what p

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Syftet med uppsatsen är att presentera möjligheter att hänföra en PMSCs (Private Military and Security Company) överträdelser av internationell rätt till en kontrakterande Stat. Uppsatsen fokuserar på relevanta bestämmelser i ARSIWA som det huvudsakliga rättsliga ramverket för Statsansvar. Uppsatsen presenterar definitionen av PMSCs och relevanta egenskaper rörande dess arbetssätt och organisationThe aim of the thesis is to present the possibilities of attributing the unlawful conduct of a Private Military and Security Company (PMSC) to a contracting State. It focuses on relevant provisions of ARSIWA as the main legal framework on State responsibility for wrongful acts. It will focus on relevant characteristics of PMSCs that contribute to the assessment of these entities under the law of a

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The complement system can be activated by three different pathways in the body. It is wanted to be able to detect deficiencies of these activation pathways and Bioporto A/S has acquired the commercial rights to a set of ELISA based assays. There is a need in these commercial assays for optimisation of dilution and wash buffers since the idea with the ELISA kit is to sell it as a “ready-to-use kit”

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UPPSATSEN ÄR SKRIVEN I ÄMNET TJECKISKA (KURS TJE252). The history of gender equality in the Czech Republic i's long and diverse. Thi's thesi's aim's to provide a concise mapping of it's development, with the purpose to illustrate and explain factor's that have consequence's to thi's day. The principal focu's of the study i's the civic women''s movem

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Language is a powerful tool in the creation of social identities. This work analyses the security policy discourses of two major actors in world politics: the European Union and the United States. The material is composed of security documents of both actors ranging from the time before the 9/11 terrorist attacks to present day. Discourse analysis, especially its Foucauldian strand emphasising the

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International law related to patents, on the one side, and human rights, on the other, both constitute interesting areas of law on their own. From time-to time the two distinct fields of international law intertwine. A tragic but highly relevant example is the ongoing HIV/AIDS epidemic. The core of law-related considerations of the HIV/AIDS epidemic consists of specific parts of the two fields, na

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Four problem areas with FrontPac‟s previous cost estimation system were identified. First, only a few properly skilled employees are actually able to perform cost estimations due to the system‟s user requirements. Second, salespersons cannot estimate the cost for orders by themselves which significantly increases the time to approximate price in the sales process. Third, neither can they perform s

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This essay explores the refugee’s access to human rights in regard to the case of Hirsi Jamaa and others v. Italy. The status of refugee, official or not, entails certain rights and state obligation, but the correlation between refugee rights and human rights is problematic. The analysis of the case parties’ arguments for and against violation of relevant articles of the European Convention for th

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Sedan våren 2014 har delar av Ukrainas östra territorium kontrollerats av separatister som understödjs av Ryssland. Separatisterna har utropat nya folkrepubliker, som dock inte erkänts som nya stater av det internationella samfundet. På grund av separatisternas territoriella kontroll kan Ukraina inte säkerställa att Europakonventionen om de mänskliga rättigheterna efterlevs och respekteras i regioWhen Ukraine lost control over parts of its eastern territory to separatists in 2014, it indicated that it no longer had the ability to fulfil its obligations under the European Convention of Human Rights in regards to that area. However, although the separatists have proclaimed their own states, these are not recognised by the international community. Since the ECHR only applies to state parties

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A single intradermal injection of the mineral oil pristane in susceptible DA.1F rats induces erosive arthritis closely mimicking rheumatoid arthritis (RA). Pristane-induced arthritis (PIA) is driven by autoreactive T cells but no autoantigen has been identified to date. We therefore analyzed B and T cell responses to autoantigens potentially involved in the pathogenesis of RA, including IgG, citru

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Meniscectomy is recognized as an important risk factor for the development of knee osteoarthritis (OA), a disease that traditionally has been considered as a simple "wear and tear" phenomenon. However, despite numerous reports, little evidence has been presented that a limited meniscal resection, compared with a more extensive resection, reduces the risk of OA by preserving meniscal function. Why?

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We present a qualitative physical model of the origin of two very brightUV lines of Fe II at 2507-2509 Å, present in high-resolutionspectra of gaseous condensations (blobs) close to the central star ofeta Carinae. The spectra have been obtained with the Hubble SpaceTelescope (HST). The model is based on a type of Bowen mechanism withselective photoexcitation of Fe II by a broad HLyalpha profile,ge

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We compared the efficiency of some commercially available products and methods used for remediation of mould-contaminated building materials. Samples of gypsum board and pinewood were artificially contaminated with toxin-producing isolates of Stachybotrys chartarum and Aspergillus versicolor, respectively, then, ten different remediation treatments were applied according to the manufacturers' inst

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Perimetric probability maps depict visual field results in terms of the frequency with which the measured findings are seen in a normal population. We tested clinically the importance of the model of the normal visual field used to calculate such maps. Forty-one eyes of 41 normal subjects and 58 eyes of 46 glaucomatous patients were studied. Probability maps were calculated by means of two differe

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Background: Acute type B aortic dissection (AoD) with malperfusion is a rare and complex disease. In this specific setting, invasive treatment is generally required to improve aortic branch vessel flow. Thoracic aorta stent grafting (TEVAR) of the proximal descending thoracic aorta to cover/exclude the proximal intimal entry tear would promote resolution of the dynamic component (the most prevalen

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Background: Older adults with pain have an increased risk of falling (odds ratio (OR) 1,7). Pain in Parkinson’s disease (PD) is more common than in older adults. The association between pain and falling in people with PD is poorly explored.Objective: To investigate the occurrence of pain in mild PD and its association with future falls/near fallsMethods. The study included 141 participants with PD