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Background and purpose: Up-to-date population-based information about long-term survival, causes of death and recurrence after stroke is needed. Methods: Four hundred consecutive individuals in a population-based cohort of first-ever stroke between 2015 and 2016 in Lund, Sweden, were followed up to 3 years regarding (i) survival (Swedish Population Register); (ii) causes of death (Swedish Causes o
Brain natriuretic peptide (BNP) is normally present in low levels in the circulation, but it is elevated in parallel with the degree of congestion in heart failure subjects (CHF). BNP has natriuretic effects and is a potent vasodilator. It is suggested that BNP could be a therapeutic alternative in CHF. However, we postulated that the high levels of circulating BNP in CHF may downregulate the resp
BACKGROUND: Cerebral dopamine neurotrophic factor (CDNF) is an unconventional neurotrophic factor that protects dopamine neurons and improves motor function in animal models of Parkinson's disease (PD).OBJECTIVE: The primary objectives of this study were to assess the safety and tolerability of both CDNF and the drug delivery system (DDS) in patients with PD of moderate severity.METHODS: We assess
Alkaliphilic microorganisms are one option for the treatment of cyanide-polluted wastewater. This study reports the degradation of cyanide from simulated gold mine wastewater using alkaliphilic microbial consortia harvested from a soda lake, Lake Chitu, Ethiopia. A novel aerobic-anoxic integrated treatment setup was established for the treatment process. Colorimetry was used to measure residual cy
Mutations in the NRF2-KEAP1 pathway are common in non-small cell lung cancer (NSCLC) and confer broad-spectrum therapeutic resistance, leading to poor outcomes. Currently, there is no means to non-invasively identify NRF2 activation in living subjects. Here, we show that positron emission tomography imaging with the system xc- radiotracer, [18F]FSPG, provides a sensitive and specific marker of NRF
This article uses a new database of 1,891 probate inventories from rural southern Sweden to investigate the development of rural households’ productive capacity from the late 1600s to the 1860s. Both labourers and farmers improved their material living standards – as measured by the contents of probate inventories – but the labouring households’ ownership of means of production decreased over time
This essay focuses on the reception of Pauline ideas in the Pseudo-Clementine Homilies, commonly dated to the early fourth century. At first, the claim that the Pseudo-Clementine Homilies contain Pauline ideas may seem surprising, since the Homilies are commonly considered “Jewish Christian” and thus anti-Pauline. However, new readings of Paul generated by the “Paul within Judaism” perspective, al
Objective: Children with speech sound disorders (SSDs) have difficulties affecting different levels of speech production. For treatment to be beneficial, it is important to differentiate between Childhood Apraxia of Speech (CAS)–a motor speech disorder with deficits in speech praxis–and other SSDs (nonCAS-SSD). We have previously developed a motor speech examination Dynamisk motorisk talbedömning
Mould problems in buildings have become a growing concern during the past decades. The growth of mould fungi indoors deteriorates air quality, influences human health and causes economical losses. Preventing mould growth from occurring is a more cost effective option than cleaning and renovation of buildings with mould problems. Mould growth will occur in buildings when there are moisture problem
We report the structure of a novel tetrameric form of the lactose repressor (LacI) protein from Escherichia coli refined to 2.1 A resolution. The tetramer is bound to 1.6-hexanediol present in the crystallization solution and the final R(free) for the structure is 0.201. The structure confirms previously reported structures on the monomer level. However, the tetramer is much more densely packed. T
BACKGROUND: The early detection of bacterial meningitis is crucial for successful outcome. Heparin-binding protein, a potent inducer of increased vascular permeability, is released from activated neutrophils in severe sepsis.OBJECTIVE: In this study we investigated whether heparin-binding protein levels in cerebrospinal fluid could be used as a diagnostic marker for acute bacterial meningitis.DESI
Many patients with Parkinson's disease (PD) experiencing L-DOPA-induced dyskinesia (LID) receive adjunct treatment with dopamine agonists, whose functional impact on LID is unknown. We set out to compare temporal and topographic profiles of abnormal involuntary movements (AIMs) after L-DOPA dose challenges including or not the dopamine agonist ropinirole. Twenty-five patients with PD and a history
Zinc is essential for all organisms and yet detrimental at elevated levels. Hence, homeostasis of this metal is tightly regulated. The Zrt/Irt-like proteins (ZIPs) represent the only zinc importers in metazoans. Mutations in human ZIPs cause serious disorders, but the mechanism by which ZIPs transfer zinc remains elusive. Hitherto, structural information is only available for a model member, BbZIP
This work investigates the impact of the magnet segmentation on the continuous performance of an interior permanent magnet synchronous machine of a battery electric vehicle. Electromagnetic and thermal simulations, as well as thermal laboratory experiments are performed for the solid magnet reference design and the segmented magnet variant, and the results are compared, in order to verify the impa
Background: The aim of the present study was to investigate the incidence and hallmarks of long-term survivors of recurrent ovarian carcinoma (LTSROC) in a large-scale retrospective cohort of patients from a multicenter study group. Methods: We performed a regional multicenter retrospective study between January 1986 and September 2021 using clinical data collected under the central pathological r
Human PBL from vaccinated healthy blood donors, which was transplanted i.p. into mice with severe combined immunodeficiency (SCID), exhibited an Ag-dependent humoral Ir against tetanus toxoid. This Ir was dose dependent and was completely abrogated by immunizing with large amounts of Ag, suggesting a high dose tolerization of the B cells. A dose-dependent selection of specific, high affinity B clo
Technological developments now make it possible to employ many markers for many individuals in a phylogeographic setting, even for taxa with large and complex genomes such as salamanders. The banded newt (genus Ommatotriton) from the Near East has been proposed to contain three species (O. nesterovi, O. ophryticus and O. vittatus) with unclear phylogenetic relationships, apparently limited intersp
Brewster angle micrographs have been obtained of the development of a silica film grown at an air-water interface with use of the surfactant template cetylpyridinium chloride. The micrograph images showed that the growing silica film exhibited complex, fractal-like patterns. These images have been analyzed to determine the values of the fractal dimension and lacunarity, and the forms of the autoco
We investigate the formation of self-bound quantum droplets in a one-dimensional binary mixture of bosonic atoms, applying the method of numerical diagonalization of the full Hamiltonian. The excitation spectra and ground-state pair correlations signal the formation of a few-boson droplet when crossing the region of critical interspecies interactions. The self-binding affects the rotational excita
