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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 192355 hits

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The “Green Sahara” is a period when North Africa was characterized by vegetation cover and wetlands. To qualitatively identify the orbital-climatic causation of the Green Sahara regime, we performed dynamic vegetation model (LPJ-GUESS) simulations, driven by climate forcings from coupled general circulation model (EC-Earth) simulations for the mid-Holocene, in which the vegetation is prescribed to

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This paper presents an in-depth manufacturing cost analysis of conventional wrought steel gear manufacturing and a case study of a spur engine gear is evaluated by real usage data, including a benchmark in gear manufacturing cost calculations between the participating company cost calculation method and the model used and developed in this research. The applicability of the developed manufacturing

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Archaeobotany and GIS are closely linked with archaeology, it is hard to imagine a modern archaeological investigation without them. The two appear to complement each other. GIS links highly complex sets of data with space, and offers a range of analytical tools. Archaeobotanists look for patterns in data over time and space to interpret human behaviour. Yet GIS is underused in archaeobotany. Ther

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At the beginning of this century, the EU set itself the ambitious goal of becoming the most competitive, sustainable and dynamic knowledge-based economy in the world. In this context, the concept of corporate social responsibility is gradually presenting itself as the hidden key to success. This means that companies should not just aim at financial gain, but should also take up societal and enviro

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In recent years, Predictive Digital Twins (PDT) have emerged as a potential tool to monitor and predict the behavior of dynamic systems, including nature-based solutions in natural coastal systems. Here, we test the potential of using a simple, coupled shoreline and beach-dune model as a base for a PDT. The models exchange sediment flux balance information at each time step and recalculate shoreli

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This paper is part of a conceptual study of a multiuser OFDM system. In previous reports we have examined requirements for the air interface and presented uncoded performance (in terms of bit error rate) for the uplink of such systems. In this report we adopt the user allocation structure from the previous parts of the study and examine the role of channel coding. We present performance simulation

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Although the communication aspects of sport and football organizations are receiving in-creased scholarly attention, research from the perspective of fans of such organizations has mostly been neglected. This study problematizes the gap that exists be-tween the current social media communication of football organizations, that tend to be guided by commercial interests, and the expectation of fans

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This thesis project was performed in collaboration with Scania CV AB’s cab factory in Oskarshamn, Sweden, and the objective was to accomplish a product development process regarding a new assembly skid from an ergonomic perspective. A great number of aspects had to be noticed and evaluated, both regarding the process the skid is aiming to support and the product it concerns. The focus was the func

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Local seafood movements have recently emerged in North America with the aims of enhancing connections between fishermen and consumers, towards improved environmental, economic, and social sustainability. Community supported fisheries (CSFs), in particular, have arisen as a new business model for linking seafood producers to local markets. However, little research has been carried out on the likely

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This thesis investigates how cooperative membership impacts on the well-being of the individual. The case of the umbrella cooperative El Ceibo, operating in Bolivia, is investigated. Organizations such as the UN, the World Bank, and the ILO have high hopes for agricultural cooperatives as partners in the struggle for rural development. However, there is a lack of empirical studies investigating th

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Presence of perivascular neuroblastoma cells with high expression of hypoxia inducible factor (HIF)-2α correlates with distant metastasis and aggressive disease. Regulation of HIFs are traditionally considered to occur post-translationally, but we have recently shown that HIF-2α is unconventionally regulated also at the transcriptional level in neuroblastoma cells. Regulatory factors binding direc

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Mitigating degradation is essential for extending the lifetime of solid oxide electrochemical cells (SOCs). The conditions leading to degradation, e.g. overpotentials, gas partial pressures, thermal gradients are hard, if not impossible, to retrieve experimentally. Thus, to deconvolute the response from cell testing, modeling can be applied to understand the degradation phenomena in greater detail

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To assess recharge through floodwater spreading, three wells, approx. 30 m deep, were dug in a 35-year-old basin in southern Iran. Hydraulic parameters of the layers were measured. One well was equipped with pre-calibrated time domain reflectometry (TDR) sensors. The soil moisture was measured continuously before and after events. Rainfall, ponding depth and the duration of the flooding events wer

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European managed grasslands are amongst the most productive in the world. Besides temperature and the amount and timing of precipitation, grass production is also highly controlled by applications of nitrogen fertilizers and land management to sustain a high productivity. Since management characteristics of pastures vary greatly across Europe, land-use intensity and their projections are critical

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One of the biggest obstacles to economic profitability of solar water heating systems is the investment cost. Retrofitting existing domestic hot water heaters when a new solar hot water system is installed can reduce both the installation and material costs. In this study, retrofitting existing water heaters for solar water heating systems in Swedish single-family houses was theoretically investig

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Brain natriuretic peptide (BNP) is normally present in low levels in the circulation, but it is elevated in parallel with the degree of congestion in heart failure subjects (CHF). BNP has natriuretic effects and is a potent vasodilator. It is suggested that BNP could be a therapeutic alternative in CHF. However, we postulated that the high levels of circulating BNP in CHF may downregulate the resp

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The sun and its heat are two of the most universal symbols known to humanity, yet their supposed meanings vary greatly. The sun can be thought of as a giver of life, but its hot and scorching rays can also be associated with drought and the powers of destruction. The present study concerns the latter view of the sun and related ideas as reflected in the Hebrew Bible and the cuneiform alphabetic te