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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 114808 hits

5G SLAM Using the Clustering and Assignment Approach with Diffuse Multipath

5G communication systems operating above 24 GHz have promising properties for user localization and environment mapping. Existing studies have either relied on simplified abstract models of the signal propagation and the measurements, or are based on direct positioning approaches, which directly map the received waveform to a position. In this study, we consider an intermediate approach, which con

Budget impact analysis of introducing digital breast tomosynthesis in breast cancer screening in Italy

Purpose: This study quantifies the impact on budget and cost per health benefit of implementing digital breast tomosynthesis (DBT) in place of digital mammography (DM) for breast cancer screening among asymptomatic women in Italy. Methods: A budget impact analysis and a cost consequence analysis were conducted using parameters from the MAITA project and literature. The study considered four scenar

Global trends of pCO2 across the Cretaceous–Paleogene boundary supported by the first Southern Hemisphere stomatal proxy-based pCO2 reconstruction

Reliable reconstructions of atmospheric carbon dioxide concentrations (pCO2) are required at higher resolution than currently available to help resolve the relationship between mass extinctions and changes in palaeo-pCO2 levels. Such reconstructions are needed: 1, at a high temporal resolution for constraining the pre- and post-extinction atmospheres; and 2, at a sufficient spatial resolution to c

Does DFT-D estimate accurate energies for the binding of ligands to metal complexes?

We have studied the homolytic dissociation of a methyl radical from a model of methyl cobalamin. For this reaction, density functional theory with an atom-pairwise dispersion correction (DFT-D) gives a dispersion contribution to the bond dissociation energy (BDE) of 22-51 kJ mol(-1) depending on the functional, i.e. much more than common estimates for the total dispersion interaction energy of the

Molecular changes during progression from nonmuscle invasive to advanced urothelial carcinoma

Molecular changes occurring during invasion and clinical progression of cancer are difficult to study longitudinally in patient-derived material. A unique feature of urothelial bladder cancer (UBC) is that patients frequently develop multiple nonmuscle invasive tumors, some of which may eventually progress to invade the muscle of the bladder wall. Here, we use a cohort of 73 patients that experien

Deformation Plasticity Based Topology Optimization of Anisotropic Elastoplastic Structures

This thesis presents a topology optimization framework for anisotropic elastoplastic structures based on the deformation theory of plasticity. Traditional methods often assume linear elasticity and isotropic material behavior, which limits their ability to model real-world materials that exhibit anisotropy and undergo plastic deformation. Although incremental elastoplastic models can accurately ca

Segmenting Countries in the Food Packaging Market: A Cluster Analysis Approach

The food packaging market has been witnessing substantial growth due to changing consumer lifestyles, urbanization, increased purchasing power, and growing environmental sustainability awareness. This growth presents significant opportunities for companies operating in this market. To effectively capitalize on these opportunities, it is crucial to develop marketing strategies and forecasting analy