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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 114930 hits

An Explainable AI and LLM-Assisted Framework for Within-Household SARS-CoV-2 Secondary Transmission Risk Prediction in Sweden

Artificial intelligence (AI) is playing an expanding role in infectious disease surveillance and intervention planning by enabling analysis of large-scale health data. One of the key challenges in this area is to characterize transmission within households and to identify factors that influence both infectivity and susceptibility. The present study focuses on the COVID-19 pandemic, which not only

Post-outbreak serological screening for SARS-CoV-2 infection in healthcare workers at a Swedish University Hospital

BACKGROUND: Nosocomial outbreaks of coronavirus disease 2019 (COVID-19) can have devastating consequences from both a resource cost and patient healthcare perspective. Relying on reverse transcription-polymerase chain reaction (RT-PCR) for identifying infected individuals may result in missed cases. Screening for antibodies after an outbreak can help to find missed cases and better illuminate rout

The hinge-engineered IgG1-IgG3 hybrid subclass IgGh47 potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodies

Streptococcus pyogenes can cause invasive disease with high mortality despite adequate antibiotic treatments. To address this unmet need, we have previously generated an opsonic IgG1 monoclonal antibody, Ab25, targeting the bacterial M protein. Here, we engineer the IgG2-4 subclasses of Ab25. Despite having reduced binding, the IgG3 version promotes stronger phagocytosis of bacteria. Using atomic

The role of super-spreaders in modeling of SARS-CoV-2

In stochastic modeling of infectious diseases, it has been established that variations in infectivity affect the probability of a major outbreak, but not the shape of the curves during a major outbreak, which is predicted by deterministic models (Diekmann et al., 2012). However, such conclusions are derived under idealized assumptions such as the population size tending to infinity, and the indivi

Abrupt decreases in infectivity of SARS-CoV-2 in aerosols

A respiratory virus emitted in an aerosol particle will experience a tough journey with many obstacles before finding a new host where it can cause an infection (Fig. 1). By every second, its chances to replicate decrease due to removal by building ventilation, deposition on surfaces, or loss in infectivity. Thus, the transport of infectious viruses from the exhaled breath of one person to the inh