Search results

Filter

Filetype

Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 114341 hits

Creating B-Spline Representations of Tree Stems from LiDAR Point Cloud Data

The development of decision-assisting tools for use in forestry operations has the potential to improve the adherence to forest management best practices, which could benefit biodiversity and increase the economic efficiency of the forest industry. NFA Forestry Automation AB is developing a system that leverages information about the forest environment extracted from data collected with harvester-

Flexible Density-based Multipath Component Clustering Utilizing Ground Truth Pose

Accurate statistical characterization of electromagnetic propagation is necessary for the design and deployment of radio systems. State-of-the-art channel models such as the Enhanced COST 2100 Channel Model utilize the concept of clusters of multipath components, and characterize channels by their inter- and intra-cluster statistics. Automatic clustering algorithms have been proposed in literature

Synthetic Approach towards N-acetylneuraminic Acid 5-C Amine Derivatives as Potential Drug Targets

Sialinsyra är en kolhydrat som finns i och på nästan alla däggdjursceller och fyller många funktioner. En viktig funktion är att agera som kommunikatör mellan celler. Många virus och bakterier använder sig av sialinsyra för att hitta rätt cell att infektera medan andra använder sialinsyra som en mantel för att gömma sig för immunförsvaret. Detta kan användas som ett verktyg för att utveckla mediciSialic acids are nine-carbon carbohydrates that are present and essential in nearly all mammalian cells. Sialic acids have many functions such as molecular recognition, cell adhesion, and markers for pathogens. Some pathogens can take advantage of mammalian sialic acids and disguise themselves as host cells in a phenomenon that is called pathogenic mimicry. By doing this, the bacteria and virus in

Mining geosocial data from Flickr to explore tourism patterns: The case study of Athens

Kanari Domna Mining geosocial data from Flickr to explore tourism patterns: The case study of Athens Social media are providing a new type of geo-tagged data that by processing them, new types of knowledge can be generated and used by decision-makers in different areas including tourism. It includes e.g., identifying touristic areas that are not prioritized or advertised by touristic authorities

Compressed spike-triggered averaging in iterative decomposition of surface EMG

Background and Objective: Analysis of motor unit activity is important for assessing and treating diseases or injuries affecting natural movement. State-of-the-art decomposition translates high-density surface electromyography (HDsEMG) into motor unit activity. However, current decomposition methods offer far from complete separation of all motor units. Methods: This paper proposes a peel-off appr

Evolutionary analysis of the Chikungunya virus epidemic in Mexico reveals intra-host mutational hotspots in the E1 protein

The epidemic potential of Chikungunya virus (CHIKV) was recently made evident by its introduction and rapid expansion in the Caribbean and the Americas. We sought to gain a detailed understanding of the dynamics of the epidemic in Mexico, the country with the highest number of confirmed CHIKV cases in the Americas, and to characterise viral evolution at the population and intra-host level. Analysi

The incidence and distribution of CpG----TpG transitions in the coagulation factor IX gene. A fresh look at CpG mutational hotspots

The mutations of 76 haemophilia B patients representing the whole population registered with the Malmö haemophilia centre (42) and referrals from the UK, were characterised. RFLP haplotype analysis of the defective genes indicated that 51 single base pair substitutions were definitely of independent origin and 27 of these were CpG----TpG or CpA transitions. This represents a 38-fold excess over ot

Sequence specificity in CpG mutation hotspots

CpG dinucleotides are efficiently methylated in vertebrate genomes except in the CpG islands having a high C+G content. Methylated CpGs are the single most mutated dinucleotide. Sequences surrounding disease causing CpG mutation sites were analyzed from locus-specific mutation databases. Both tetra- and heptanucleotide analyses indicated clear overall sequence preference for having pyrimidines 5'

Anomaly detection in 5G beam propagation

Advancements in today's technology has motivated invention of faster mobile communication systems. The fifth generation mobile network, 5G, is the latest version made by the third generation partnership project (3GPP) and expects to both increase connection speed and reduce latency, which eventually will make it applicable in supporting state-of-the art technologies such as virtual reality and

Dynamic Spatio-Temporal Tweet Mining for Event Detection : A Case Study of Hurricane Florence

Extracting information about emerging events in large study areas through spatiotemporal and textual analysis of geotagged tweets provides the possibility of monitoring the current state of a disaster. This study proposes dynamic spatio-temporal tweet mining as a method for dynamic event extraction from geotagged tweets in large study areas. It introduces the use of a modified version of ordering

The CoV-Y domain of SARS-CoV-2 Nsp3 interacts with BRAP to stimulate NF-κB signaling and induce host inflammatory responses

Non-structural protein 3 (Nsp3) is the largest protein encoded by the coronavirus (CoV) genome. It consists of multiple domains that perform critical functions during the viral life cycle. CoV-Y is the most C-terminal domain of Nsp3, and it exhibits evolutionary conservation across diverse CoVs; however, the exact biological function of CoV-Y remains unclear. Here, we determined the crystal struct