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We present a topology optimization framework for anisotropic elastoplastic structures based on a new deformation plasticity formulation derived directly from Hill’s yield criterion. Conventional incremental elastoplastic approaches in topology optimization, while accurate, are computationally demanding due to their path-dependent nature and the need to store internal variables over multiple load s
It is unclear if the results of randomised controlled trials (RCTs) of behaviour therapy (BT) for Tourette syndrome (TS) and chronic tic disorder (CTD) can be generalised to naturalistic clinical settings and are durable long-term. In this naturalistic study, 74 young people with TS/CTD received BT at a specialist clinic. Data were collected at baseline, post-treatment, and at 3-, 6-, and 12-month
Accurate statistical characterization of electromagnetic propagation is necessary for the design and deployment of radio systems. State-of-the-art channel models such as the Enhanced COST 2100 Channel Model utilize the concept of clusters of multipath components, and characterize channels by their inter- and intra-cluster statistics. Automatic clustering algorithms have been proposed in literature
Reliable reconstructions of atmospheric carbon dioxide concentrations (pCO2) are required at higher resolution than currently available to help resolve the relationship between mass extinctions and changes in palaeo-pCO2 levels. Such reconstructions are needed: 1, at a high temporal resolution for constraining the pre- and post-extinction atmospheres; and 2, at a sufficient spatial resolution to c
Purpose: This study quantifies the impact on budget and cost per health benefit of implementing digital breast tomosynthesis (DBT) in place of digital mammography (DM) for breast cancer screening among asymptomatic women in Italy. Methods: A budget impact analysis and a cost consequence analysis were conducted using parameters from the MAITA project and literature. The study considered four scenar
Objectives: Non-small cell lung cancer (NSCLC) is a heterogeneous disease with unique combinations of somatic molecular alterations in individual patients, as well as significant differences in populations across the world with regard to mutation spectra and mutation frequencies. Here we aim to describe mutational patterns and linked clinical parameters in a population-based NSCLC cohort. Material
We have studied the homolytic dissociation of a methyl radical from a model of methyl cobalamin. For this reaction, density functional theory with an atom-pairwise dispersion correction (DFT-D) gives a dispersion contribution to the bond dissociation energy (BDE) of 22-51 kJ mol(-1) depending on the functional, i.e. much more than common estimates for the total dispersion interaction energy of the
This thesis presents a topology optimization framework for anisotropic elastoplastic structures based on the deformation theory of plasticity. Traditional methods often assume linear elasticity and isotropic material behavior, which limits their ability to model real-world materials that exhibit anisotropy and undergo plastic deformation. Although incremental elastoplastic models can accurately ca
Molecular changes occurring during invasion and clinical progression of cancer are difficult to study longitudinally in patient-derived material. A unique feature of urothelial bladder cancer (UBC) is that patients frequently develop multiple nonmuscle invasive tumors, some of which may eventually progress to invade the muscle of the bladder wall. Here, we use a cohort of 73 patients that experien
