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Most drugs act on biomacromolecules. The Cost of developing new drugs is very high. A method to accurately predict binding affinities would be very useful. We have studied molecular mechanics with generalised Born and surface--area solvation (MM/GBSA) and alchemical free energy perturbation methods (FEP) for use in calculations of ligand binding energies. For the MM/GBSA method we have tested: Ca

Popular Abstract in Swedish The phenol oxidase “laccase” was first described towards the end of the 19th century from the wound sap of the lacquer tree Rhus vernicifera. However, its use in one of the oldest biotechnologies, i.e. the making of lacquerware in East-Asia, dates back to 5000-6000 BC. The enzyme has the widest distribution in nature among the multicopper oxidases. It catalyzes one elecLaccase, the phenol oxidizing enzyme, was first described towards the end of the 19th century from the wound sap of the lacquer tree Rhus vernicifera. The enzyme has the widest distribution in nature among the multicopper oxidases. It catalyzes single electron transfer oxidation in the presence of molecular oxygen producing water as by-product. Based on these highly desired mild oxidising conditio

The detections of over 4000 exoplanets as of today has shown that they exist in a wide range of different configurations, otherwise known as architectures. Recently, studies have been made trying to link the environment of host stars to the architectures of their planetary systems and have found that the architectures of planetary systems may not necessarily be uniform in the Milky Way. Since effe

Methods: Drug-induced interstitial lung disease (ILD) is crucial to detect early to achieve the best treatment outcome. Optimally, non-invasive imaging biomarkers can be used for early detection of disease progression and treatment follow-up. Therefore, reliable in vivo models are warranted in new imaging biomarker development to accelerate better-targeted treatment options. Single-dose bleomycin

Combustion, present in a vast majority of energy and material production as well as in transportation, represents a foundation of our modern society. To improve and optimize the applications relying on combustion demand a high level of knowledge, and an ability to simulate the combustion process. To do so three-dimensional Computational Fluid Dynamic (CFD) combustion simulations can be used, whereCombustion, present in a vast majority of energy and material production as well as in transportation, represents a foundation of our modern society. To improve and optimize the applications relying on combustion demand a high level of knowledge, and an ability to simulate the combustion process. To do so three-dimensional Computational Fluid Dynamic (CFD) combustion simulations can be used, where

Eight Brides for Twenty-Four Brothers Four Brides for Twelve Brothers: How to Dutch Book a Group of Individually Rational Players 1 Luc Bovens London School of Economics and Political Science Dept. of Philosophy, Logic and Scientific Method L.Bovens@LSE.ac.uk You can’t be wise and in love at the same time. (Bob Dylan) Abstract. Wlodek Rabinowicz suggested in an e-mail conversation (2001) to me tha

https://www.fil.lu.se/hommageawlodek/site/papper/BovensLuc.pdf - 2026-05-29

This thesis studies the relationship between history and nationalism as expressed by the political parties the Sweden Democrats and the Danish People's Party. The study focuses on how the Sweden Democrats and the Danish People's Party convey historical narratives in their party magazines, SD-Kuriren and Dansk Folkeblad, respectively, and in central party documents. The narrative theory being imple

Osteoblasts, osteocytes, and osteoclasts (OCs) are involved in the bone production and resorption, which are crucial in bone homeostasis. OC hyperactivation plays a role in the exaggerated bone resorption of diseases such as osteoporosis, rheumatoid arthritis, and osteolytic tumor metastases. This work stems from the finding that OCs can express B7h (ICOS-Ligand), which is the ligand of the ICOS T